Theranostics, Journal Year: 2024, Volume and Issue: 14(9), P. 3634 - 3652
Published: Jan. 1, 2024
: Molecular imaging of microenvironment by hypoxia-activatable fluorescence probes has emerged as an attractive approach to tumor diagnosis and image-guided treatment. Difficulties remain in its translational applications due hypoxia heterogeneity microenvironments, making it challenging image a reliable proxy distribution.
Language: Английский
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 7547 - 7566
Published: July 1, 2024
Abstract: Cancer poses a significant threat to human life and health. Chemotherapy is currently one of the effective cancer treatments, but many chemotherapy drugs have cell toxicity, low solubility, poor stability, narrow therapeutic window, unfavorable pharmacokinetic properties. To solve above problems, target drug delivery tumor cells, reduce side effects drugs, an anti-tumor system based on microenvironment has become focus research in recent years. The construction reduction-sensitive nanomedicine disulfide bonds attracted much attention. Disulfide good reductive responsiveness can effectively high glutathione (GSH) levels environment, enabling precise delivery. further enhance targeting accelerate release, are often combined with pH-responsive nanocarriers highly expressed ligands cells construct systems. connect molecules polymer system, as well between different carrier molecules. This article summarized systems (DDS) that researchers constructed years bond microenvironment, cleavage-triggering conditions, various loading strategies, design. In this review, we also discuss controlled release mechanisms these DDS clinical applicability challenges faced translation. Keywords: bond, systems, GSH/ROS
Language: Английский
Citations
22
ChemMedChem, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 20, 2025
Abstract Macrocyclic supramolecular materials play an important role in encapsulating anticancer drugs to improve the efficiency and reduce toxicity normal tissues through host‐guest interactions. Among them, pillar[n]arenes, as emerging class of macrocyclic compounds, have attracted increasing attention drug delivery drug‐controlled release due their high biocompatibility, excellent chemistry, simplicity modification. In this review, we summarize research progress pillar[n]arene‐based nanodrug systems (SNDs) recent years field tumor therapy, including release, imaging diagnostics therapeutic modalities. Furthermore, opportunities major limitations SNDs for therapy are discussed.
Language: Английский
Citations
1
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(4)
Published: July 1, 2024
Polymer-drug conjugates and polymer-protein have been pivotal in the realm of drug delivery systems for over half a century. These polymeric drugs are characterized by conjugation therapeutic molecules or functional moieties to polymers, enabling range benefits including extended circulation times, targeted delivery, controlled release, decreased immunogenicity. This review delves into recent advancements challenges clinical translations preclinical studies polymer-drug conjugates. The design principles functionalization strategies crucial development these were explored followed structural properties characteristics various polymer carriers. also identifies significant obstacles translation provides insights directions their future development. article is categorized under: Therapeutic Approaches Drug Discovery > Nanomedicine Oncologic Disease.
Language: Английский
Citations
6
Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 180, P. 394 - 406
Published: April 12, 2024
Language: Английский
Citations
4
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: March 26, 2025
Metastasis is the leading cause of death in patients with lung cancer. Multidisciplinary comprehensive treatments (MDT), including surgery, chemotherapy, radiotherapy, gene-targeted therapy, immunotherapy, antibody-drug conjugate (ADC), natural products, etc., have been currently used for cancer metastasis. The MDT model has shown promising efficacy against metastasis clinical practice. However, these therapies some limitations, such as unusual toxic side effects, drug resistance, limited indications, and high costs. Therefore, emerging technological platforms are imperative to overcome bottlenecks. Nanomedicine can be prepare efficient delivery systems owing its good biocompatibility, targeting, responsive release, multidrug codelivery plays an important role synergistic antimetastasis because optical, acoustic, electrical, thermal, magnetic functions. This review analyses limitations model, briefly outlines advantages nanotechnology, introduces nanodrug systems, summarizes nanostrategies based on invasion-metastasis cascade process, provides a summary prospects challenges translation nanomedicines.
Language: Английский
Citations
0
Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 538, P. 216643 - 216643
Published: April 18, 2025
Language: Английский
Citations
0
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: April 26, 2025
Language: Английский
Citations
0
ACS Omega, Journal Year: 2025, Volume and Issue: unknown
Published: May 30, 2025
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 490, P. 151437 - 151437
Published: April 23, 2024
Language: Английский
Citations
3
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 377, P. 495 - 523
Published: Nov. 29, 2024
Language: Английский
Citations
3