Journal of Functional Biomaterials,
Journal Year:
2024,
Volume and Issue:
15(11), P. 346 - 346
Published: Nov. 14, 2024
This
study
aimed
to
assess
the
impact
of
titanium
surface
patterning
used
in
combination
with
photobiomodulation
therapy
on
enhancing
osseointegration
osteoporotic
bone
fractures.
C.p.
implants
were
employed,
half
an
unmodified
and
a
modified
one,
showing
nanostructured
cellular
surface.
Surface
obtain
complex
morphology
designed
for
better
osseointegration,
using
selective
anodization
process
after
photoresist
coating.
A
total
52
rats
used,
which
4
sacrificed
12
weeks
ovariectomy
evaluate
density.
48
received
both
tibiae
underwent
surgery
implant
placement
fracture.
Half
subjected
photobiomodulation.
The
times
sacrifice
2,
4,
6
finalizing
LASER
therapy.
evaluation
methods
micro-CT
scanning,
mechanical
pull-force
test,
morphology.
Mechanical
tests
revealed
significant
difference
surface-patterned
group
at
2
weeks,
but
not
weeks.
outperformed
regular
titanium/LASER
groups.
Micro-CT
showed
no
differences,
while
indicated
quality
all
LASER-treated
effect
leads
especially
earlier
stages.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
31, P. 101531 - 101531
Published: Feb. 5, 2025
Three-dimensional
(3D)
printing
technology
has
shown
significant
promise
in
the
medical
field,
particularly
orthopedics,
prosthetics,
tissue
engineering,
and
pharmaceutical
preparations.
This
review
focuses
on
innovative
application
of
3D
addressing
challenges
osteonecrosis
femoral
head
(ONFH).
Unlike
traditional
hip
replacement
surgery,
which
is
often
suboptimal
for
younger
patients,
offers
precise
localization
necrotic
areas
ability
to
create
personalized
implants.
By
integrating
advanced
biomaterials,
this
a
promising
strategy
approach
early
hip-preserving
treatments.
Additionally,
3D-printed
bone
engineering
scaffolds
can
mimic
natural
environment,
promoting
regeneration
vascularization.
In
future,
potential
extends
combining
with
artificial
intelligence
optimizing
treatment
plans,
developing
materials
enhanced
bioactivity
compatibility,
translating
these
innovations
from
laboratory
clinical
practice.
demonstrates
how
uniquely
addresses
critical
ONFH
treatment,
including
insufficient
vascularization,
poor
mechanical
stability,
limited
long-term
success
conventional
therapies.
introducing
gradient
porous
scaffolds,
bioactive
material
coatings,
AI-assisted
design,
work
outlines
novel
strategies
improve
interventions.
These
advancements
not
only
enhance
efficacy
but
also
pave
way
findings
into
applications.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(39), P. 9863 - 9893
Published: Jan. 1, 2024
Schematic
diagram
of
the
device,
mechanism
and
biomedical
application
electrodeposition
for
preparation
bioactive
coatings
on
surface
titanium
implants
bone
repair.
Frontiers in Cell and Developmental Biology,
Journal Year:
2025,
Volume and Issue:
13
Published: March 6, 2025
Wear
particle-induced
periprosthetic
osteolysis
is
a
prevalent
issue
that
frequently
leads
to
the
failure
of
joint
replacements,
necessitating
development
effective
therapeutic
strategies.
In
this
study,
we
established
mouse
model
prosthetic
loosening
and
evaluated
effects
targeting
tumor
necrosis
factor-alpha
(TNF-α)
wingless-type
MMTV
integration
site
family,
member
3A
(Wnt3a)
on
osteolysis.
TNF-α
knockdown
reduced
inflammation
osteoclast-related
gene
expression,
while
Wnt3a
overexpression
increased
osteoblast-related
expression.
Notably,
combination
these
interventions
showed
superior
efficacy
in
inhibiting
compared
monotherapy.
Biomechanical
imaging
histological
staining
revealed
combined
therapy
enhanced
bone
density
minimized
gaps
between
peri-prosthetic
prosthesis,
reducing
fibrous
connective
tissue
proliferation.
Adeno-associated
virus-mediated
was
found
be
safe,
with
no
adverse
observed
liver,
brain,
spleen,
kidney
tissues.
Our
findings
suggest
combining
silencing
may
promising
approach
for
treating
peri-implant
warrants
further
clinical
investigation.
