Porphyrin-based-MOF nanocomposite hydrogels for synergistic sonodynamic and gas therapy against tumor DOI

Yunqi Kuang,

Ziwen Zhang,

K. S. Zhu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 136086 - 136086

Published: Sept. 1, 2024

Language: Английский

Engineered Cell Microenvironments: A Benchmark Tool for Radiobiology DOI Creative Commons

Qais Akolawala,

Angelo Accardo

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

The development of engineered cell microenvironments for fundamental mechanobiology, in vitro disease modeling, and tissue engineering applications increased exponentially during the last two decades. In such context, radiobiology is a field research aiming at understanding effects ionizing radiation (e.g., X-rays/photons, high-speed electrons, protons) on biological (cancerous) tissues cells, particular terms DNA damage leading to death. Herein, perspective provides comparative assessment overview scaffold-free, scaffold-based, organ-on-a-chip models radiobiology, highlighting opportunities, limitations, future pathways improve currently existing approaches toward personalized cancer medicine.

Language: Английский

Citations

0
Three-dimensional bioprinted in vitro glioma tumor constructs for synchrotron microbeam radiotherapy dosimetry and biological study using gelatin methacryloyl hydrogel DOI Creative Commons
John Paul O Bustillo, E. Engels,

Vincent de Rover

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 22, 2025

Language: Английский

Citations

0
Precision Spatial Control of Tumor‐Stroma Interactions in Cancer Models via 3D Bioprinting for Advanced Research and Therapy DOI
Yan Li, Haijun Cui, Haitao Cui

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract As an emerging technology for modeling cancer tissue in vitro, 3D bioprinting facilitates precise spatial manipulation of cells and biomaterials, allowing the replication complex architectures accurate recapitulation tumor microenvironment (TME) features. This review initially elucidates mechanisms underlying tumorigenesis associated TME complexity, with a particular focus on roles stromal cell populations characteristics extracellular matrix (ECM) progression. Moreover, this work summarizes recent advances bioprinted models, emphasizing their application studying cell‐ECM interactions, stromal‐tumor crosstalk, vasculature formation investigating occurrence metastasis, as well utility high‐throughput drug screening therapeutic development. Finally, discusses advantages challenges creating biomimetic while providing insights into future development trajectories potential translational applications research personalized medicine. By focusing these critical dimensions, aims to highlight transformative role advancing vitro models ultimate goal improving treatment, prevention, patient outcomes.

Language: Английский

Citations

0
Matrix-Bound EGF Promotes Malignant Phenotypes of Breast Cancer Organoids in the Biomimetic ECM of Alginate DOI Creative Commons
Xueyu Chen, Mengyuan Wang,

Xin Shu

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101818 - 101818

Published: April 29, 2025

Language: Английский

Citations

0
Porphyrin-based-MOF nanocomposite hydrogels for synergistic sonodynamic and gas therapy against tumor DOI

Yunqi Kuang,

Ziwen Zhang,

K. S. Zhu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 136086 - 136086

Published: Sept. 1, 2024

Language: Английский

Citations

3