Materials Advances in Devices for Heart Disease Interventions DOI Creative Commons
Gagan K. Jalandhra,

Lauryn Srethbhakdi,

James Davies

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Abstract Heart disease encompasses a range of conditions that affect the heart, including coronary artery disease, arrhythmias, congenital heart defects, valve and muscle. Intervention strategies can be categorized according to when they are administered include: 1) Monitoring cardiac function using sensor technology inform diagnosis treatment, 2) Managing symptoms by restoring output, electrophysiology, hemodynamics, often serving as bridge‐to‐recovery or bridge‐to‐transplantation strategies, 3) Repairing damaged tissue, myocardium valves, management insufficient. Each intervention approach require specific material properties optimally, relying on materials support their action interface with body, new technologies increasingly depending advances in science engineering. This review explores requirements driving innovation advanced for highlights key examples recent progress field driven research.

Language: Английский

Reverse Gradient Distributions of Drug and Polymer Molecules within Electrospun Core–Shell Nanofibers for Sustained Release DOI Open Access
Y. Chen,

Wenjian Gong,

Zhiyuan Zhang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9524 - 9524

Published: Sept. 1, 2024

Core–shell nanostructures are powerful platforms for the development of novel nanoscale drug delivery systems with sustained release profiles. Coaxial electrospinning is facile and convenient creating medicated core–shell elaborate designs which sustained-release behaviors molecules can be intentionally adjusted. With resveratrol (RES) as a model poorly water-soluble cellulose acetate (CA) PVP polymeric carriers, brand-new electrospun nanostructure was fabricated in this study. The guest RES host CA were designed to have reverse gradient distribution within nanostructures. Scanning electron microscope transmission evaluations verified that these nanofibers had linear morphologies, without beads or spindles, an obvious double-chamber structure. X-ray diffraction patterns Fourier transform infrared spectroscopic results indicated involved components highly compatible presented amorphous molecular state. In vitro dissolution tests new structures able prevent initial burst release, extend continuous-release time period, reduce negative tailing-off effect, thus ensuring better profile than traditional blended drug-loaded nanofibers. mechanism underlying influence structure RES/CA on proposed. Based proof-of-concept demonstration, series advanced functional nanomaterials similarly developed based distributions multi-chamber

Language: Английский

Citations

24
Synergistic Effects of Radical Distributions of Soluble and Insoluble Polymers within Electrospun Nanofibers for an Extending Release of Ferulic Acid DOI Open Access

Ran Dong,

Wenjian Gong,

Qiuyun Guo

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(18), P. 2614 - 2614

Published: Sept. 15, 2024

Polymeric composites for manipulating the sustained release of an encapsulated active ingredient are highly sought after many practical applications; particularly, water-insoluble polymers and core–shell structures frequently explored to manipulate behaviors drug molecules over extended time period. In this study, electrospun nanostructures were utilized develop a brand-new strategy tailor spatial distributions both insoluble polymer (ethylcellulose, EC) soluble (polyvinylpyrrolidone, PVP) within nanofibers, thereby extended-release loaded ingredient, ferulic acid (FA). Scanning electron microscopy transmission assessments revealed that all prepared nanofibers had linear morphology without beads or spindles, those from coaxial processes obvious structure. X-ray diffraction attenuated total reflectance Fourier transform infrared spectroscopic tests confirmed FA fine compatibility with EC PVP, presented in amorphous state. vitro dissolution indicated radical (decreasing shell core) PVP (increasing able play their important role elaborately. On one hand, F3 advantages homogeneous composite F1 higher content solutions inhibit initial burst provide longer period release. other F2 core negative tailing-off The key element was water permeation rates, controlled by ratios polymers. new based on structure paves way developing wide variety polymeric heterogeneous realizing desired functional performances.

Language: Английский

Citations

20
Synergistic improvements of properties of cellulose acetate based curcumin@TiO2 nanofibers via triaxial electrospinning DOI

Wenbin Deng,

Yu Liu,

Cui He

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 506, P. 160117 - 160117

Published: Jan. 1, 2025

Language: Английский

Citations

8
Shell Distribution of Vitamin K3 within Reinforced Electrospun Nanofibers for Improved Photo-Antibacterial Performance DOI Open Access

Wenjian Gong,

Menglong Wang, Yanan Liu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9556 - 9556

Published: Sept. 3, 2024

Personal protective equipment (PPE) has attracted more attention since the outbreak of epidemic in 2019. Advanced nano techniques, such as electrospinning, can provide new routes for developing novel PPE. However, electrospun antibacterial PPE is not easily obtained. Fibers loaded with photosensitizers prepared using single-fluid electrospinning have a relatively low utilization rate due to influence embedding and their inadequate mechanical properties. For this study, monolithic nanofibers core–shell were compared. Monolithic F1 fibers comprising polyethylene oxide (PEO), poly(vinyl alcohol-co-ethylene) (PVA-co-PE), photo-antibacterial agent vitamin K3 (VK3) created blending process. Core–shell F2 coaxial which extensible material PEO was set core section, composite consisting PEO, PVA-co-PE, VK3 shell section. Both designed structural properties had an average diameter approximately 1.0 μm, determined scanning electron microscopy transmission microscopy. amorphously dispersed within polymeric matrices compatible manner, revealed X-ray diffraction Fourier transform infrared spectroscopy. higher tensile strength 2.917 ± 0.091 MPa, whereas longer elongation break 194.567 0.091%. Photoreaction tests showed that, adjustment, could produce 0.222 μmol/L ·OH upon illumination. slightly better performance than fibers, inhibition zones 1.361 0.012 cm 1.296 0.022 E. coli S. aureus, respectively, but less VK3. The intentional tailoring components compositions nanostructures improve process–structure–performance relationship potential sunlight-activated

Language: Английский

Citations

16
Recent Advances in Degradable Biomedical Polymers for Prevention, Diagnosis and Treatment of Diseases DOI
Shuoxun Zhang, Huapan Fang,

Huayu Tian

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(11), P. 7015 - 7057

Published: Oct. 18, 2024

Biomedical polymers play a key role in preventing, diagnosing, and treating diseases, showcasing wide range of applications. Their unique advantages, such as rich source, good biocompatibility, excellent modifiability, make them ideal biomaterials for drug delivery, biomedical imaging, tissue engineering. However, conventional suffer from poor degradation

Language: Английский

Citations

6
Mechanical bionic compression resistant fiber/hydrogel composite artificial heart valve suitable for transcatheter surgery DOI
Yajuan Wang, Yuxin Chen, Wenshuo Wang

et al.

Composites Part B Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 112234 - 112234

Published: Feb. 1, 2025

Language: Английский

Citations

0
Biomaterials for neuroengineering: Applications and challenges DOI Creative Commons

Huanghui Wu,

E.J. Feng,

Huazong Yin

et al.

Regenerative Biomaterials, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 1, 2025

Abstract Neurological injuries and diseases are a leading cause of disability worldwide, underscoring the urgent need for effective therapies. Neural regaining enhancement therapies seen as most promising strategies restoring neural function, offering hope individuals affected by these conditions. Despite their promise, path from animal research to clinical application is fraught with challenges. Neuroengineering, particularly through use biomaterials, has emerged key field that paving way innovative solutions It seeks understand treat neurological disorders, unravel nature consciousness, explore mechanisms memory brain’s relationship behavior, tissue engineering, interfaces targeted drug delivery systems. These including both natural synthetic types, designed replicate cellular environment brain, thereby facilitating repair. This review aims provide comprehensive overview biomaterials in neuroengineering, highlighting functional across basic practice. covers recent developments biomaterial-based products, 2D 3D bioprinted scaffolds cell organoid culture, brain-on-a-chip systems, biomimetic electrodes brain–computer interfaces. also explores artificial synapses networks, discussing applications modeling microenvironments repair regeneration, modulation manipulation integration traditional Chinese medicine. serves guide role advancing neuroengineering solutions, providing insights into ongoing efforts bridge gap between innovation application.

Language: Английский

Citations

0
Electrospun nanofibers and their application as sensors for healthcare DOI Creative Commons
Yiting Zhao, Jie Huang, Xingjian Yang

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: March 20, 2025

Electrospinning is a type of electrohydrodynamics that utilizes high-voltage electrostatic force to stretch polymer solution into nanofibers under the influence an electric field, with most fibers falling onto collector. This technology favored by researchers across various fields due its simple and inexpensive device for producing in straightforward manner. Nanofibers prepared through electrospinning have high specific surface area porosity. shows extensive potential, especially within biomedical sensors. article provides systematic overview factors influencing electrospinning, parameters process, types electrospun nanofibers, applications field sensors, including wearable pressure glucose The paper summarizes research progress this points out direction development technology, as well future challenges.

Language: Английский

Citations

0
Optimizations of Electrospun Nylon Fibers Toward Potential Application in Artificial Heart Valve DOI Open Access
Gaigai Duan,

Minmin Ding,

Xiuling Yang

et al.

Journal of Applied Polymer Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

ABSTRACT Improving the mechanical properties of novel prosthetic heart valves is key to facilitating application biological valves. Screening polymer materials that can be used for basis preparation This study focused on screening and optimization different types nylon electrospun fibers. First, nylon‐6 (PA 6), nylon‐66 66), nylon‐612 612), nylon‐11 11), nylon‐12 12) were selected as spinning precursors, only PA 6, 66, 12 completely dissolved obtain a solution with concentration 16 wt%. Among them, 12, 66 fiber membranes. Then, fibrous membranes obtained under conditions 19 kV, distance 15–20 cm, humidity 20%, then three investigated compared each other fibers nylon, such tensile strength, Young's modulus, toughness. Finally, we chose 6 spinneret designed solutions gradients, subsequently prepared at an optimal wt% voltage excellent overall performance: diameter was concentrated 0.19 ± 0.02 μm. The toughness 10.25 0.518 MPa, 101.12 5.85 2.51 0.145 MJ m −3 , respectively. promising candidate new

Language: Английский

Citations

0
Materials Advances in Devices for Heart Disease Interventions DOI Creative Commons
Gagan K. Jalandhra,

Lauryn Srethbhakdi,

James Davies

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Abstract Heart disease encompasses a range of conditions that affect the heart, including coronary artery disease, arrhythmias, congenital heart defects, valve and muscle. Intervention strategies can be categorized according to when they are administered include: 1) Monitoring cardiac function using sensor technology inform diagnosis treatment, 2) Managing symptoms by restoring output, electrophysiology, hemodynamics, often serving as bridge‐to‐recovery or bridge‐to‐transplantation strategies, 3) Repairing damaged tissue, myocardium valves, management insufficient. Each intervention approach require specific material properties optimally, relying on materials support their action interface with body, new technologies increasingly depending advances in science engineering. This review explores requirements driving innovation advanced for highlights key examples recent progress field driven research.

Language: Английский

Citations

0