Reverse Gradient Distributions of Drug and Polymer Molecules within Electrospun Core–Shell Nanofibers for Sustained Release
Y. Chen,
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Wenjian Gong,
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Zhiyuan Zhang
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et al.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(17), P. 9524 - 9524
Published: Sept. 1, 2024
Core–shell
nanostructures
are
powerful
platforms
for
the
development
of
novel
nanoscale
drug
delivery
systems
with
sustained
release
profiles.
Coaxial
electrospinning
is
facile
and
convenient
creating
medicated
core–shell
elaborate
designs
which
sustained-release
behaviors
molecules
can
be
intentionally
adjusted.
With
resveratrol
(RES)
as
a
model
poorly
water-soluble
cellulose
acetate
(CA)
PVP
polymeric
carriers,
brand-new
electrospun
nanostructure
was
fabricated
in
this
study.
The
guest
RES
host
CA
were
designed
to
have
reverse
gradient
distribution
within
nanostructures.
Scanning
electron
microscope
transmission
evaluations
verified
that
these
nanofibers
had
linear
morphologies,
without
beads
or
spindles,
an
obvious
double-chamber
structure.
X-ray
diffraction
patterns
Fourier
transform
infrared
spectroscopic
results
indicated
involved
components
highly
compatible
presented
amorphous
molecular
state.
In
vitro
dissolution
tests
new
structures
able
prevent
initial
burst
release,
extend
continuous-release
time
period,
reduce
negative
tailing-off
effect,
thus
ensuring
better
profile
than
traditional
blended
drug-loaded
nanofibers.
mechanism
underlying
influence
structure
RES/CA
on
proposed.
Based
proof-of-concept
demonstration,
series
advanced
functional
nanomaterials
similarly
developed
based
distributions
multi-chamber
Language: Английский
Synergistic Effects of Radical Distributions of Soluble and Insoluble Polymers within Electrospun Nanofibers for an Extending Release of Ferulic Acid
Ran Dong,
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Wenjian Gong,
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Qiuyun Guo
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et al.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(18), P. 2614 - 2614
Published: Sept. 15, 2024
Polymeric
composites
for
manipulating
the
sustained
release
of
an
encapsulated
active
ingredient
are
highly
sought
after
many
practical
applications;
particularly,
water-insoluble
polymers
and
core–shell
structures
frequently
explored
to
manipulate
behaviors
drug
molecules
over
extended
time
period.
In
this
study,
electrospun
nanostructures
were
utilized
develop
a
brand-new
strategy
tailor
spatial
distributions
both
insoluble
polymer
(ethylcellulose,
EC)
soluble
(polyvinylpyrrolidone,
PVP)
within
nanofibers,
thereby
extended-release
loaded
ingredient,
ferulic
acid
(FA).
Scanning
electron
microscopy
transmission
assessments
revealed
that
all
prepared
nanofibers
had
linear
morphology
without
beads
or
spindles,
those
from
coaxial
processes
obvious
structure.
X-ray
diffraction
attenuated
total
reflectance
Fourier
transform
infrared
spectroscopic
tests
confirmed
FA
fine
compatibility
with
EC
PVP,
presented
in
amorphous
state.
vitro
dissolution
indicated
radical
(decreasing
shell
core)
PVP
(increasing
able
play
their
important
role
elaborately.
On
one
hand,
F3
advantages
homogeneous
composite
F1
higher
content
solutions
inhibit
initial
burst
provide
longer
period
release.
other
F2
core
negative
tailing-off
The
key
element
was
water
permeation
rates,
controlled
by
ratios
polymers.
new
based
on
structure
paves
way
developing
wide
variety
polymeric
heterogeneous
realizing
desired
functional
performances.
Language: Английский
Synergistic improvements of properties of cellulose acetate based curcumin@TiO2 nanofibers via triaxial electrospinning
Wenbin Deng,
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Yu Liu,
No information about this author
Cui He
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et al.
Chemical Engineering Journal,
Journal Year:
2025,
Volume and Issue:
506, P. 160117 - 160117
Published: Jan. 1, 2025
Language: Английский
Shell Distribution of Vitamin K3 within Reinforced Electrospun Nanofibers for Improved Photo-Antibacterial Performance
Wenjian Gong,
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Menglong Wang,
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Yanan Liu
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et al.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(17), P. 9556 - 9556
Published: Sept. 3, 2024
Personal
protective
equipment
(PPE)
has
attracted
more
attention
since
the
outbreak
of
epidemic
in
2019.
Advanced
nano
techniques,
such
as
electrospinning,
can
provide
new
routes
for
developing
novel
PPE.
However,
electrospun
antibacterial
PPE
is
not
easily
obtained.
Fibers
loaded
with
photosensitizers
prepared
using
single-fluid
electrospinning
have
a
relatively
low
utilization
rate
due
to
influence
embedding
and
their
inadequate
mechanical
properties.
For
this
study,
monolithic
nanofibers
core–shell
were
compared.
Monolithic
F1
fibers
comprising
polyethylene
oxide
(PEO),
poly(vinyl
alcohol-co-ethylene)
(PVA-co-PE),
photo-antibacterial
agent
vitamin
K3
(VK3)
created
blending
process.
Core–shell
F2
coaxial
which
extensible
material
PEO
was
set
core
section,
composite
consisting
PEO,
PVA-co-PE,
VK3
shell
section.
Both
designed
structural
properties
had
an
average
diameter
approximately
1.0
μm,
determined
scanning
electron
microscopy
transmission
microscopy.
amorphously
dispersed
within
polymeric
matrices
compatible
manner,
revealed
X-ray
diffraction
Fourier
transform
infrared
spectroscopy.
higher
tensile
strength
2.917
±
0.091
MPa,
whereas
longer
elongation
break
194.567
0.091%.
Photoreaction
tests
showed
that,
adjustment,
could
produce
0.222
μmol/L
·OH
upon
illumination.
slightly
better
performance
than
fibers,
inhibition
zones
1.361
0.012
cm
1.296
0.022
E.
coli
S.
aureus,
respectively,
but
less
VK3.
The
intentional
tailoring
components
compositions
nanostructures
improve
process–structure–performance
relationship
potential
sunlight-activated
Language: Английский
Recent Advances in Degradable Biomedical Polymers for Prevention, Diagnosis and Treatment of Diseases
Shuoxun Zhang,
No information about this author
Huapan Fang,
No information about this author
Huayu Tian
No information about this author
et al.
Biomacromolecules,
Journal Year:
2024,
Volume and Issue:
25(11), P. 7015 - 7057
Published: Oct. 18, 2024
Biomedical
polymers
play
a
key
role
in
preventing,
diagnosing,
and
treating
diseases,
showcasing
wide
range
of
applications.
Their
unique
advantages,
such
as
rich
source,
good
biocompatibility,
excellent
modifiability,
make
them
ideal
biomaterials
for
drug
delivery,
biomedical
imaging,
tissue
engineering.
However,
conventional
suffer
from
poor
degradation
Language: Английский
Mechanical bionic compression resistant fiber/hydrogel composite artificial heart valve suitable for transcatheter surgery
Composites Part B Engineering,
Journal Year:
2025,
Volume and Issue:
unknown, P. 112234 - 112234
Published: Feb. 1, 2025
Language: Английский
Biomaterials for neuroengineering: Applications and challenges
Huanghui Wu,
No information about this author
E.J. Feng,
No information about this author
Huazong Yin
No information about this author
et al.
Regenerative Biomaterials,
Journal Year:
2025,
Volume and Issue:
12
Published: Jan. 1, 2025
Abstract
Neurological
injuries
and
diseases
are
a
leading
cause
of
disability
worldwide,
underscoring
the
urgent
need
for
effective
therapies.
Neural
regaining
enhancement
therapies
seen
as
most
promising
strategies
restoring
neural
function,
offering
hope
individuals
affected
by
these
conditions.
Despite
their
promise,
path
from
animal
research
to
clinical
application
is
fraught
with
challenges.
Neuroengineering,
particularly
through
use
biomaterials,
has
emerged
key
field
that
paving
way
innovative
solutions
It
seeks
understand
treat
neurological
disorders,
unravel
nature
consciousness,
explore
mechanisms
memory
brain’s
relationship
behavior,
tissue
engineering,
interfaces
targeted
drug
delivery
systems.
These
including
both
natural
synthetic
types,
designed
replicate
cellular
environment
brain,
thereby
facilitating
repair.
This
review
aims
provide
comprehensive
overview
biomaterials
in
neuroengineering,
highlighting
functional
across
basic
practice.
covers
recent
developments
biomaterial-based
products,
2D
3D
bioprinted
scaffolds
cell
organoid
culture,
brain-on-a-chip
systems,
biomimetic
electrodes
brain–computer
interfaces.
also
explores
artificial
synapses
networks,
discussing
applications
modeling
microenvironments
repair
regeneration,
modulation
manipulation
integration
traditional
Chinese
medicine.
serves
guide
role
advancing
neuroengineering
solutions,
providing
insights
into
ongoing
efforts
bridge
gap
between
innovation
application.
Language: Английский
Electrospun nanofibers and their application as sensors for healthcare
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
13
Published: March 20, 2025
Electrospinning
is
a
type
of
electrohydrodynamics
that
utilizes
high-voltage
electrostatic
force
to
stretch
polymer
solution
into
nanofibers
under
the
influence
an
electric
field,
with
most
fibers
falling
onto
collector.
This
technology
favored
by
researchers
across
various
fields
due
its
simple
and
inexpensive
device
for
producing
in
straightforward
manner.
Nanofibers
prepared
through
electrospinning
have
high
specific
surface
area
porosity.
shows
extensive
potential,
especially
within
biomedical
sensors.
article
provides
systematic
overview
factors
influencing
electrospinning,
parameters
process,
types
electrospun
nanofibers,
applications
field
sensors,
including
wearable
pressure
glucose
The
paper
summarizes
research
progress
this
points
out
direction
development
technology,
as
well
future
challenges.
Language: Английский
Optimizations of Electrospun Nylon Fibers Toward Potential Application in Artificial Heart Valve
Gaigai Duan,
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Minmin Ding,
No information about this author
Xiuling Yang
No information about this author
et al.
Journal of Applied Polymer Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 28, 2025
ABSTRACT
Improving
the
mechanical
properties
of
novel
prosthetic
heart
valves
is
key
to
facilitating
application
biological
valves.
Screening
polymer
materials
that
can
be
used
for
basis
preparation
This
study
focused
on
screening
and
optimization
different
types
nylon
electrospun
fibers.
First,
nylon‐6
(PA
6),
nylon‐66
66),
nylon‐612
612),
nylon‐11
11),
nylon‐12
12)
were
selected
as
spinning
precursors,
only
PA
6,
66,
12
completely
dissolved
obtain
a
solution
with
concentration
16
wt%.
Among
them,
12,
66
fiber
membranes.
Then,
fibrous
membranes
obtained
under
conditions
19
kV,
distance
15–20
cm,
humidity
20%,
then
three
investigated
compared
each
other
fibers
nylon,
such
tensile
strength,
Young's
modulus,
toughness.
Finally,
we
chose
6
spinneret
designed
solutions
gradients,
subsequently
prepared
at
an
optimal
wt%
voltage
excellent
overall
performance:
diameter
was
concentrated
0.19
±
0.02
μm.
The
toughness
10.25
0.518
MPa,
101.12
5.85
2.51
0.145
MJ
m
−3
,
respectively.
promising
candidate
new
Language: Английский
Materials Advances in Devices for Heart Disease Interventions
Gagan K. Jalandhra,
No information about this author
Lauryn Srethbhakdi,
No information about this author
James Davies
No information about this author
et al.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 17, 2025
Abstract
Heart
disease
encompasses
a
range
of
conditions
that
affect
the
heart,
including
coronary
artery
disease,
arrhythmias,
congenital
heart
defects,
valve
and
muscle.
Intervention
strategies
can
be
categorized
according
to
when
they
are
administered
include:
1)
Monitoring
cardiac
function
using
sensor
technology
inform
diagnosis
treatment,
2)
Managing
symptoms
by
restoring
output,
electrophysiology,
hemodynamics,
often
serving
as
bridge‐to‐recovery
or
bridge‐to‐transplantation
strategies,
3)
Repairing
damaged
tissue,
myocardium
valves,
management
insufficient.
Each
intervention
approach
require
specific
material
properties
optimally,
relying
on
materials
support
their
action
interface
with
body,
new
technologies
increasingly
depending
advances
in
science
engineering.
This
review
explores
requirements
driving
innovation
advanced
for
highlights
key
examples
recent
progress
field
driven
research.
Language: Английский