Bio‐Inspired Dynamically Morphing Microelectronics toward High‐Density Energy Applications and Intelligent Biomedical Implants

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(26)

Published: Feb. 25, 2024

Choreographing the adaptive shapes of patterned surfaces to exhibit designable mechanical interactions with their environment remains an intricate challenge. Here, a novel category strain-engineered dynamic-shape materials, empowering diverse multi-dimensional shape modulations that are combined form fine-grained microarchitectures is introduced. Using micro-origami tessellation technology, heterogeneous materials provided strategic creases featuring stimuli-responsive micro-hinges morph precisely upon chemical and electrical cues. Freestanding multifaceted foldable packages, auxetic mesosurfaces, morphable cages three forms demonstrated herein these complex 4-dimensional (4D) metamaterials. These systems integrated in dual proof-of-concept bioelectronic demonstrations: soft supercapacitor enhancing its power density (≈108 mW cm

Language: Английский

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Advanced Neuromorphic Applications Enabled by Synaptic Ion‐Gating Vertical Transistors

Advanced Science, Journal Year: 2024, Volume and Issue: 11(27)

Published: May 17, 2024

Bioinspired synaptic devices have shown great potential in artificial intelligence and neuromorphic electronics. Low energy consumption, multi-modal sensing recording, multifunctional integration are critical aspects limiting their applications. Recently, a new device architecture, the ion-gating vertical transistor (IGVT), has been successfully realized timely applied to perform brain-like perception, such as vision, touch, taste, hearing. In this short time, IGVTs already achieved faster data processing speeds more promising memory capabilities than many conventional devices, even while operating at lower voltages consuming less power. This work focuses on cutting-edge progress of IGVT technology, from outstanding fabrication strategies design realization low-voltage multi-sensing for artificial-synapse The fundamental concepts IGVTs, signal processing, transduction, plasticity, multi-stimulus perception discussed comprehensively. contribution draws special attention development optimization flexible sensor technologies presents roadmap future high-end theoretical experimental advancements research that mostly achievable by IGVTs.

Language: Английский

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Single‐Response Duplexing of Electrochemical Label‐Free Biosensor from the Same Tag

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(11)

Published: Jan. 21, 2024

Abstract Multiplexing is a valuable strategy to boost throughput and improve clinical accuracy. Exploiting the vertical, meshed design of reproducible low‐cost ultra‐dense electrochemical chips, unprecedented single‐response multiplexing typical label‐free biosensors reported. Using cheap, handheld one‐channel workstation single redox probe, that is, ferro/ferricyanide, recognition events taking place on two spatially resolved locations same working electrode can be tracked along voltammetry scan by collecting signatures probe in relation different quasi‐reference electrodes, Au (0 V) Ag/AgCl ink (+0.2 V). This spatial isolation prevents crosstalk between tags interferences over functionalization binding steps, representing an advantage existing non‐spatially multiplex strategies. As proof concept, peptide‐tethered immunosensors are demonstrated provide duplex detection COVID‐19 antibodies, thereby doubling while achieving 100% accuracy serum samples. The approach envisioned enable broad applications high‐throughput multi‐analyte platforms, as it tailored other biosensing devices formats.

Language: Английский

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Ultradense Electrochemical Chips with Arrays of Nanostructured Microelectrodes to Enable Sensitive Diffusion-Limited Bioassays

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 17(9), P. 13037 - 13049

Published: March 27, 2024

Nanostructured microelectrodes (NMEs) are an attractive alternative to yield sensitive bioassays in unprocessed samples. However, although valuable for different applications, nanoporous NMEs usually cannot boost the sensitivity of diffusion-limited analyses because enlarged Debye length within nanopores, which reduces their accessibility. To circumvent this limitation, nanopore-free gold were electrodeposited from 45 μm SU-8 apertures, featuring nanoridged microspikes on a recessed surface thin film while carrying interconnected crown-like and spiky structures along edge passivation layer. These grown onto ultradense, vertical array chips that offer promising strategy translating reproducible, high-resolution, cost-effective sensors into real-world applications. The yielded reproducible analyses, machine learning allowed us predict analytical responses NME electrodeposition data. By taking advantage high area accessible structure NMEs, these provided [Fe(CN)6]3-/4- was 5.5× higher than bare WEs also delivering moderate antibiofouling property undiluted human plasma. As proof concept, electrodes applied toward fast (22 min) simple determination Staphylococcus aureus by monitoring oxidation [Fe(CN)6]4-, acted as cellular respiration rate redox reporter. showed wide dynamic range, spanning 5 orders magnitude, calculated limit detection 0.2 CFU mL-1.

Language: Английский

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A natural fibre based sustainable and high-performance platform for electrochemical sensors

RSC Sustainability, Journal Year: 2024, Volume and Issue: 2(6), P. 1849 - 1858

Published: Jan. 1, 2024

Sugarcane skin natural fibre based sustainable electrochemical sensors developed for wide applicability ranging from glucose sensing to heavy metal detection.

Language: Английский

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Colorectal Cancer Label-Free Impedimetric Immunosensor for Blood-Based Biomarker CCSP-2

ACS Measurement Science Au, Journal Year: 2025, Volume and Issue: 5(1), P. 87 - 95

Published: Feb. 5, 2025

Colorectal cancer (CRC) is one of the most treatable cancers, yet it ranks second in mortality worldwide. Early detection significantly impacts treatment outcomes, but early stage CRC often presents no symptoms or nonspecific symptoms. The current screening methods are invasive and lacks specificity, hindering widespread efforts. This underscores urgent need for improved tools. In this study, a label-free impedimetric immunosensor detecting colon cancer-secreted protein-2 (CCSP-2), which exhibits mean 78-fold increase primary cancers compared to normal mucosa, was developed. Our cost-effective noninvasive electrochemical CCSP-2 biomarker aims facilitate diagnosis monitoring CRC. designed features functionalized gold electrode (Au) modified with cysteine-modified recombinant protein G (RPGCys) immobilize antibody (Ab), bovine serum albumin (BSA) used prevent sensor surface fouling. Electrochemical impedance spectroscopy (EIS) cyclic voltammetry (CV) were employed analyze response binding antigen (Ag) Ab. changes relative charge transfer resistance (ΔR ct/R cti) varying concentrations Ag plotted calibration curve established between ΔR cti logarithm concentration assess sensor's sensitivity. demonstrated linear (R 2 = 0.95) within range 10-100 ng/μL, plateauing after 100 limit 0.71 ng/μL. Statistical analysis specificity selectivity studies showed significant differences blank BSA, both without cell extracts. effectively detects high sensitivity specificity. Integrating other sensors biomarkers present promising approach developing diagnostic prognostic tools

Language: Английский

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Ultradense Array of On-Chip Sensors for High-Throughput Electrochemical Analyses

ACS Sensors, Journal Year: 2024, Volume and Issue: 9(8), P. 4089 - 4097

Published: July 12, 2024

High-throughput sensors are valuable tools for enabling massive, fast, and accurate diagnostics. To yield this type of electrochemical device in a simple low-cost way, high-density arrays vertical gold thin-film microelectrode-based demonstrated, leading to the rapid serial interrogation dozens samples (10 μL droplets). Based on 16 working ultramicroelectrodes (UMEs) 3 quasi-reference electrodes (QREs), total 48 were engineered 3D crossbar arrangement that devised low number conductive lines. By exploiting design, compact chip (75 × 35 mm) can enable performing sequential analyses without intersensor interferences by dropping one sample per UME finger. In practice, electrical connection was achieved simply switching contact among WE adjacent fingers. Importantly, short analysis time ensured interrogating UMEs with chronoamperometry or square wave voltammetry using hand-held one-channel potentiostat. As proof concept, detection

Language: Английский

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A novel sensing probe based on AuNPs-Apt for the detection of enrofloxacin

Nanotechnology, Journal Year: 2024, Volume and Issue: 36(4), P. 045501 - 045501

Published: Nov. 8, 2024

Abstract Enrofloxacin (ENR), as a synthetic broad-spectrum antibiotic is widely utilized in veterinary medicine to treat animal diseases and promote livestock growth, it can inhibit bacterial DNA gyrase subunit A, thereby preventing replication exerting its antibacterial effect. However, excessive use of enrofloxacin poses significant risks ecological balance human health due residual contamination. We have developed novel ENR aptamer sensor based on the gold nanoparticles/aptamer (AuNPs-Apt) complexes, which AuNPs were synthesized via seed method functionalized with aptamers. The optical properties, particle size, functional groups morphology AuNPs-Apt probe characterized by transmission electron microscope, Fourier transform infrared spectrometer UV–vis spectrophotometer, respectively. biosensor specifically identify enrofloxacin, wide detection range (0.05–100 μ g ml −1 ) good linear relationship ( R 2 =0.99) within range. In addition, also has advantages short time, low biological toxicity, stability, cost. Therefore, shows great prospect for practical application field detecting residues.

Language: Английский

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Ultradense Electrochemical Chip and Machine Learning for High-Throughput, Accurate Anticancer Drug Screening

ACS Sensors, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 29, 2024

Despite the potentialities of electrochemical sensors, these devices still encounter challenges in devising high-throughput and accurate drug susceptibility testing. The lack platforms for providing analyses over preclinical trials candidates remains a significant barrier to developing medicines. In this way, ultradense chips are combined with machine learning (ML) enable high-throughput, user-friendly, determination viability 2D tumor cells (breast colorectal) aiming at assays. effect doxorubicin (anticancer model) was assessed through cell detachment assays by interrogating Ru(NH3)63+ square wave voltammetry (SWV). This positive probe is presumed imply sensitive monitoring on-sensor cellular death because its electrostatic preconcentration so-called nanogap zone between electrode surface adherent cells. High-throughput were obtained merging fast individual SWV measurements (9 s) ability yield series. approach's applicability demonstrated across two analysis formats, drop-casting microfluidic One should also mention that fitting multivariate descriptor from selected input data via ML proved be essential determinations (98 104%) half-maximal lethal concentration drug. achieved results underscore potential method steering sensors toward enabling screening practical applications.

Language: Английский

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