Boosting Covalent Organic Framework Luminescence by Suppressing Nonradiative Pathways† DOI
Minghao Liu, Yuanzhe Cheng, Yubin Fu

et al.

Chinese Journal of Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 28, 2024

Comprehensive Summary The construction of luminescent two‐dimensional (2D) imine‐linked covalent organic frameworks (COFs) is a formidable challenge due to the strong interlayer stacking and bond rotations that typically suppress intramolecular charge transfer (ICT), leading nonradiative energy dissipation. Herein, three COFs with tailored distances are designed modulate ICT behaviours. targeted COF (TPAZ‐TPE‐COF) achieved significantly enhanced photoluminescence quantum yield (PLQY) 21.22% in solid state by restricting rotation enlarging layer distance. This represents 3.5‐fold 530.5‐fold improvement over TPAZ‐PYTA‐COF (6.15%), which has shortened space, TPAZ‐PATA‐COF (0.04%), exhibits rotations, respectively. Importantly, TPAZ‐TPE‐COF also exceptional sensing performance for iron ions, detection limit at ppb level. Both experimental theoretical analyses reveal prominent assigned effective suppression pathways, especially those arising from vibrations. These findings pave way deliberate 2D high PL intensity, thereby expanding portfolio potential applications optoelectronics.

Language: Английский

Covalent organic frameworks: Advancing antimicrobial photodynamic therapy for next-generation treatments DOI
Leila Tabrizi, Deirdre Fitzgerald‐Hughes, Mary T. Pryce

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 528, P. 216424 - 216424

Published: Jan. 11, 2025

Language: Английский

Citations

3
Donor–acceptor type COFs with multiple fluorine groups as electron storage units to promote antimicrobial performance DOI
Baiwei Ma,

Xuanyu Lin,

Tiaotiao Zhu

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 242, P. 114101 - 114101

Published: July 18, 2024

Language: Английский

Citations

4
Reengineering of Donor–Acceptor–Donor Structured Near-Infrared II Aggregation-Induced Emission Luminogens for Starving-Photothermal Antitumor and Inhibition of Lung Metastasis DOI

Mingwang Yang,

Suyin Wang,

Xinwen Ou

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(43), P. 30069 - 30083

Published: Oct. 18, 2024

Electron acceptor possessing strong electron-withdrawing ability and exceptional stability is crucial for developing donor–acceptor–donor (D-A-D) structured aggregation-induced emission luminogens (AIEgens) with second near-infrared (NIR-II) emission. Although 6,7-diphenyl-[1,2,5] thiadiazolo [3,4-g] quinoxaline (PTQ) benzobisthiadiazole (BBT) are widely employed as NIR-II building blocks, they still suffer from limited capacity or inadequate chemo-stability under alkaline conditions. Herein, a boron difluoride formazanate (BFF) utilized to construct AIEgen, which exhibits better overall performance in terms of compared the PTQ- BBT-derived fluorophores. With finely tuned intramolecular motions D–A interaction strength, TPE-BFF simultaneously high molar extinction coefficient (ε= 4.31 × 104 M–1cm–1), (Φ = 0.49%) photothermal effect (η 58.5%), well stability. Thanks these merits, thermosensitive nanoparticles constructed by integrating antiglycolytic agent 2-deoxy-d-glucose (2DG) successfully imaging-guided antitumor lung metastasis regulating glycolysis reducing ATP-dependent heat shock proteins. Combining experimental results theoretical calculations, BFF proves be an outstanding electron design versatile AIEgens. Overall, this study offers promising alternative multifunctional AIEgens biomedical applications.

Language: Английский

Citations

3
Reprogramming Lung Redox Homeostasis by NIR Driven Ultra‐Small Pd Loaded Covalent Organic Framework Inhibits NF‐κB Pathway for Acute Lung Injury Immunotherapy DOI Creative Commons

Doudou Lei,

Lin Liao, Tao Qin

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Abstract Acute lung injury (ALI) refers to damage related cells, typically caused by an uncontrollable inflammatory response, and over‐generated reactive oxygen species (ROS). Increasing evidence suggests that reprogramming redox homeostasis holds significant potentials for the clinical treatment of ALI. Herein, simple synthesis ultra‐small Pd loaded covalent organic framework (COF) (TP@Pd) is reported, which, when combined with near infrared (NIR) irradiation, exhibits nanozyme functionalities, including multiple enzyme mimicking activities broad spectrum ROS scavenging, thereby promoting tissue repair ALI immunotherapy. Mechanistically, through therapeutic strategy TP@Pd+NIR, damaged cells tissues are ameliorated decreasing intracellular levels (total ROS, ·OH ·O 2 − ), downregulating cytokines (IL‐6, TNF‐α IL‐1β), upregulating antioxidant factor level (SOD2), inducing macrophage M2 directional polarization (downregulation iNOS CD86, upregulation IL‐10 CD206), activating immunoregulation (CD4 + /CD8 ratio increase), (upregulation HSP70 CD31), suppressing NF‐κB signaling pathway phosphorylated p65 IκBα). Furthermore, following intravenous (IV) injection in rats, TP@Pd accumulated 6 h, indicating promising efficacy via this administration route. Notably, TP@Pd+NIR demonstrated excellent synergistic effects alleviating inflammation storms, reducing diffuse alveolar damage, accelerating repair. Summarily, work has designed a novel enhancement amelioration, which may serve as approach other diseases.

Language: Английский

Citations

0
NIR-II AIEgen Nanocomplex with Suppressed Nonradiative Decay and Intersystem Crossing for High-Contrast Mesenteric Vascular Imaging DOI
Jianlin Liu, Wenjing Liu, Guanghui Liu

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 319, P. 123229 - 123229

Published: Feb. 28, 2025

Language: Английский

Citations

0
Advances on fluorescence bioimaging and photo-mediated therapy of NIR-II small molecule dyes DOI
Weijie Zhang,

Laraib,

Fangjun Huo

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 534, P. 216587 - 216587

Published: March 14, 2025

Language: Английский

Citations

0
Covalent organic frameworks in cancer theranostics: advancing biomarker detection and tumor-targeted therapy DOI

Sonia Iranpour,

Amir Abrishami, Amir Sh. Saljooghi

et al.

Archives of Pharmacal Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 22, 2025

Language: Английский

Citations

0
Recent advances in polydopamine-coated metal–organic frameworks for cancer therapy DOI Creative Commons

Jingchao He,

Guangtian Wang, Yongfang Zhou

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: April 1, 2025

The creation and development of classical multifunctional nanomaterials are crucial for the advancement nanotherapeutic treatments tumors. Currently, metal–organic frameworks (MOFs) modified with polydopamine (PDA) at forefront nanomedicine research, particularly in tumor diagnostics therapy, owing to their exceptional biocompatibility, expansive specific surface area, multifaceted functionalities, superior photothermal properties, which led significant advancements anti-tumor research. Consequently, a range anti-cancer strategies has been devised by leveraging capabilities MOFs, including intelligent drug delivery systems, photodynamic tailored microenvironment. In order gain deeper insight into role MOFs@PDA cancer diagnosis treatment, it is essential conduct comprehensive review existing research outcomes promptly analyze challenges associated biological applications. This will provide valuable perspectives on potential clinical settings.

Language: Английский

Citations

0
Tactics to Improve the Photodynamic Therapeutic Efficacy Based on Nanomaterials DOI
Yinghao Cao, Xiaoping Qian,

Mengqi Shi

et al.

Chinese Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 19, 2025

Comprehensive Summary The development of photodynamic therapy (PDT), from its initial discovery effects to current use in various medical conditions, is a testament therapeutic potential. Recent breakthroughs nanotechnology have significantly enhanced the effectiveness PDT. Typical nanomaterials (NMs), including metal‐organic frameworks (MOFs), covalent organic (COFs), and nanozymes been introduced enhance efficacy because they can delivery PSs, effectively overcome insufficient targeting specificity, limited tissue penetration depth, hypoxic microenvironments, thereby amplifying efficacy. However, clinical application these NMs PDT faces several challenges, concerns regarding biocompatibility, long‐term biosafety, economic feasibility. To further advance PDT, researchers should focus on designing improve outcomes, exploring combination therapies with conducting translational trials validate safety novel approaches. This review summarizes recent progress based NMs, especially MOFs, COFs their disease treatment. We aim provide guidance for future research practice advancing NMs‐enhanced paving way more effective strategies. Key Scientists

Language: Английский

Citations

0
Chemoselective and enantioselective fluorescent recognition of basic amino acids: A review DOI

F R Zhang,

Zhi-Yong Xu,

Li Yang

et al.

Dyes and Pigments, Journal Year: 2025, Volume and Issue: unknown, P. 112842 - 112842

Published: April 1, 2025

Language: Английский

Citations

0