Multifunctional nanofibrous scaffolds for enhancing full-thickness wound healing loaded with Bletilla striata polysaccharides DOI

Chaoyue Zhao,

Long Huang, Jingyu Tang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134597 - 134597

Published: Aug. 8, 2024

Language: Английский

Picein alleviates oxidative stress and promotes bone regeneration in osteoporotic bone defect by inhibiting ferroptosis via Nrf2/HO‐1/GPX4 pathway DOI
Lei Huang, Jiayi Wang,

Jieqin Yu

et al.

Environmental Toxicology, Journal Year: 2024, Volume and Issue: 39(7), P. 4066 - 4085

Published: May 10, 2024

Abstract Osteoporosis (OP) can result in slower bone regeneration than the normal condition due to abnormal oxidative stress and high levels of reactive oxygen species (ROS), a detrimental for formation, making OP‐related healing significant clinical challenge. As osteogenic differentiation ability marrow mesenchymal stem cells (BMSCs) is closely related regeneration; currently, this study assessed effects Picein on BMSCs vitro osteoporotic defect vivo. Cell viability was determined by CCK‐8 assay. The production malonaldehyde, superoxide dismutase activities, glutathione evaluated using commercially available kits, flow cytometry analysis adopted detect macrophage polarization. Osteogenic capacity alkaline phosphatase (ALP) activity, ALP staining, Alizarin red S staining. expression osteogenic‐related proteins (OPN, Runx‐2, OCN) genes (ALP, BMP‐4, COL‐1, Osterix) were Western blotting real‐time PCR (RT‐PCR). In addition, proliferation, migration ability, angiogenic human umbilical vein endothelial (HUVECs) EdU scratch test, transwell assay, tube formation respectively. Angiogenic‐related (VEGF, vWF, CD31) also RT‐PCR. Results showed that alleviated erastin‐induced stress, enhanced BMSCs, angiogenesis HUVECs, protects against ferroptosis through Nrf2/HO‐1/GPX4 axis. Moreover, regulate immune microenvironment promoting polarization M2 macrophages vitro. reduce inflammation promotes OP rat models Altogether, these results suggested promote alleviate via pathway, offering as novel antioxidant agent treating defect.

Language: Английский

Citations

13
Ligand‐Selective Targeting of Macrophage Hydrogel Elicits Bone Immune‐Stem Cell Endogenous Self‐Healing Program to Promote Bone Regeneration DOI Creative Commons
J Wang, Liang Zhang, Lingjun Wang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(11)

Published: Jan. 16, 2024

Targeting macrophages can facilitate the site-specific repair of critical bone defects. Herein, a composite hydrogel, gelatin-Bletilla striata polysaccharide-mesoporous bioactive glass hydrogel (GBMgel), is constructed via self-assembly mesoporous on polysaccharide structures, through Schiff base reaction. GBMgel efficiently capture and drive recruitment seed stem cells vascular budding required for regeneration in early stages injury, observed sustained release inorganic silicon ions further enhances matrix deposition, mineralization, maturation. Moreover, use macrophage-depleted rat calvarial defect models confirms that GBMgel, with ligand-selective macrophage targeting, increases area proportion mature bone. Mechanistic studies reveal upregulates TLR4/NF-κB MAPK pathways JAK/STAT3 pathway later stages; thus initiating polarization at different time points. In conclusion, this study based endogenous self-healing properties macrophages, which cell homing, provides research theoretical basis upon tissue be reshaped regenerated using body's immune power, providing new strategy treatment

Language: Английский

Citations

9
L-arginine modified mesoporous bioactive glass with ROS scavenging and NO release for periodontitis treatment DOI

Haiyan Yao,

Emine Sumeyra Turali Emre, Fan Yuan

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 200 - 216

Published: Feb. 19, 2025

Language: Английский

Citations

1
Research progress of injectable hydrogels in the treatment of bone tissue diseases DOI
Shengjie Zhang, Xiaohua Li, Chunxiao Li

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155139 - 155139

Published: Aug. 24, 2024

Language: Английский

Citations

8
Material‐Mediated Immunotherapy to Regulate Bone Aging and Promote Bone Repair DOI Open Access

Pengfei Xue,

Jiayi Wang, Yu Fu

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Abstract As the global population ages, an increasing number of elderly people are experiencing weakened bone regenerative capabilities, resulting in slower repair processes and associated risks various complications. This review outlines research progress on biomaterials that promote through immunotherapy. examines how manufacturing technologies such as 3D printing, electrospinning, microfluidic technology contribute to enhancing therapeutic effects these biomaterials. Following this, it provides detailed introductions anti‐osteoporosis drug delivery systems, injectable hydrogels, nanoparticles, engineered exosomes, well tissue engineering materials coatings used immunomodulation. Moreover, critically analyzes current limitations biomaterial‐mediated immunotherapy explores future directions for material‐mediated aims inspire new approaches broaden perspectives addressing challenges aging by exploring innovative strategies.

Language: Английский

Citations

0
The therapeutic application of hydrogels in chronic pain DOI
Zhicheng Pan, Gang Liu,

Jun-xiang Liao

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106829 - 106829

Published: March 1, 2025

Language: Английский

Citations

0
Dual-functional injectable nanofiber hydrogels with anti-inflammatory and osteogenic effects for bone regeneration DOI
Hongtao Li,

Hanping He,

Wenhui Chen

et al.

International Journal of Polymeric Materials, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: March 24, 2025

Language: Английский

Citations

0
Study of bioactive 3D-printed scaffolds incorporating zinc-based MOF for bone defect repair and anti-inflammatory applications DOI Creative Commons
Yu Han,

Xiufeng Jia,

Yinwei Yang

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101884 - 101884

Published: May 1, 2025

Language: Английский

Citations

0
Absorbable calcium and phosphorus bioactive membranes promote bone marrow mesenchymal stem cells osteogenic differentiation for bone regeneration DOI Creative Commons
Lei Huang,

Zhuorun Song,

Jiayi Wang

et al.

Open Life Sciences, Journal Year: 2024, Volume and Issue: 19(1)

Published: Jan. 1, 2024

Abstract Large segmental bone defects are commonly operated with autologous grafting, which has limited sources and poses additional surgical risks. In this study, we fabricated poly(lactide- co -glycolic acid) (PLGA)/β-tricalcium phosphate (β-TCP) composite membranes by electrostatic spinning further promoted osteogenesis regulating the release of β-TCP in hope replacing grafts clinical practice. The addition improved mechanical strength PLGA 2.55 times. Moreover, could accelerate degradation neutralize negative effects acidification microenvironment caused degradation. vitro experiments revealed that PLGA/TCP10 biocompatible released can modulate activity osteoblasts enhancing calcium ions concentration damaged area pH local microenvironment. Simultaneously, an increase moderate lactate content microenvironment, synergistically promoting tube-forming effect human umbilical vein endothelial cells. Therefore, it is potential to utilize PLGA/TCP bioactive at site promote regeneration.

Language: Английский

Citations

3
Multifunctional nanofibrous scaffolds for enhancing full-thickness wound healing loaded with Bletilla striata polysaccharides DOI

Chaoyue Zhao,

Long Huang, Jingyu Tang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134597 - 134597

Published: Aug. 8, 2024

Language: Английский

Citations

3