Inkjet-printed transparent electrodes for electrical brain stimulation DOI Creative Commons

Rita Matta,

Davide Reato,

Alberto Lombardini

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

ABSTRACT Electrical stimulation is a powerful tool for investigating and modulating brain activity, as well treating neurological disorders. However, understanding the precise effects of electrical on neural activity has been hindered by limitations in recording neuronal responses near stimulating electrode, such artifacts electrophysiology or obstruction field view imaging. In this study, we introduce novel device fabricated from conductive polymers that transparent therefore compatible with optical imaging techniques. The manufactured using combination microfabrication inkjet printing techniques flexible, allowing better adherence to brain’s natural curvature. We characterized properties electrode evaluated its performance an anesthetized mouse. Furthermore, combined experimental data finite-element model in-vivo setup estimate maximum electric highly can generate mouse brain. Our findings indicate high 300 V/m, demonstrating potential studying manipulating range relevant human applications. Overall, work presents promising approach developing versatile new tools apply study stimulation.

Language: Английский

Flexible Polymer Electrodes for Stable Prosthetic Visual Perception in Mice DOI Creative Commons
Corinne Orlemann, Christian Boehler, Roxana N. Kooijmans

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(15)

Published: Feb. 7, 2024

Brain interfaces that can stimulate neurons, cause minimal damage, and work for a long time will be central future neuroprosthetics. Here, the long-term performance of highly flexible, thin polyimide shanks with several small (<15 µm) electrodes during electrical microstimulation visual cortex, is reported. The exhibit remarkable stability when billions pulses are applied in vitro. When devices implanted primary cortex (area V1) mice animals trained to detect microstimulation, it found perceptual thresholds 2-20 microamperes (µA), which far below maximal currents withstand. functionality vivo excellent, stable up more than year little damage brain tissue. These results demonstrate potential floating restoration lost sensory functions.

Language: Английский

Citations

5
A Bioelectric Router for Adaptive Isochronous Neurostimulation DOI Creative Commons

Eashan Sahai,

Jordan Hickman, Daniel J. Denman

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Abstract Objective Multipolar intracranial electrical brain stimulation (iEBS) is a method that has potential to improve clinical applications of mono- and bipolar iEBS. Current tools for researching multipolar iEBS are proprietary, can have high entry costs, lack flexibility in managing different parameters electrodes, include features unnecessary the requisite exploratory research. This factor limiting progress understanding applying effectively. To address these challenges, we developed Bioelectric Router Adaptive Isochronous Neuro (BRAINS) board. Approach The BRAINS board cost-effective customizable device designed facilitate experiments across 16-channel electrode array using common research setups. interfaces with microcontroller, allowing users configure each channel cathodal or anodal input, establish grounded connection, maintain floating state. design prioritizes ease integration by leveraging standard like microcontroller an analog signal isolators while providing options customize setups according experimental conditions. It also ensures output isolation, reduces noise, supports remote configuration changes rapid switching states. test efficacy board, performed bench-top validation monopolar, bipolar, regimes. same regimes were tested vivo mouse primary visual cortex measured Neuropixel recordings. Main Results demonstrates no meaningful differences Root Mean Square Error (RMSE) noise signal-to-noise ratio compared baseline performance isolated stimulator alone. at rate up 600 Hz without introducing residual enabling high-frequency necessary temporally multiplexed stimulation. Significance represents significant advancement user-friendly, customizable, open source, tool capable conducting sophisticated, reproducible, finely controlled experiments. With capacity effectively real-time information processing efficient parameter exploration enhance both on enable improved use closed-loop

Language: Английский

Citations

0
Inkjet-printed transparent electrodes: Design, characterization, and initial in vivo evaluation for brain stimulation DOI Creative Commons

Rita Matta,

Davide Reato,

Alberto Lombardini

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0320376 - e0320376

Published: April 1, 2025

Electrical stimulation is a powerful tool for investigating and modulating brain activity, as well treating neurological disorders. However, understanding the precise effects of electrical on neural activity has been hindered by limitations in recording neuronal responses near stimulating electrode, such artifacts electrophysiology or obstruction field view imaging. In this study, we introduce novel device fabricated from conductive polymers that transparent therefore compatible with optical imaging techniques. The manufactured using combination microfabrication inkjet printing techniques flexible, allowing better adherence to brain’s natural curvature. We characterized properties electrodes, focusing trade-off between maximum current can be delivered transmittance. found 1 mm diameter, 350 nm thick PEDOT:PSS electrode could used apply 130 μA while maintaining 84% transmittance (approximately 50% under 2-photon conditions). then evaluated performance an anesthetized mouse measuring electric nearby values up 30 V/m. Finally, combined experimental data finite-element model vivo setup estimate distribution underneath brain. Our findings indicate generate high 300 V/m directly beneath demonstrating its potential studying manipulating range relevant human applications. Overall, work presents promising approach developing versatile new tools study stimulation.

Language: Английский

Citations

0
In vivo microelectrode arrays for neuroscience DOI
Nathaniel Williams, Mihály Vöröslakos, Delin Shi

et al.

Nature Reviews Methods Primers, Journal Year: 2025, Volume and Issue: 5(1)

Published: May 8, 2025

Citations

0
Inkjet-printed transparent electrodes for electrical brain stimulation DOI Creative Commons

Rita Matta,

Davide Reato,

Alberto Lombardini

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

ABSTRACT Electrical stimulation is a powerful tool for investigating and modulating brain activity, as well treating neurological disorders. However, understanding the precise effects of electrical on neural activity has been hindered by limitations in recording neuronal responses near stimulating electrode, such artifacts electrophysiology or obstruction field view imaging. In this study, we introduce novel device fabricated from conductive polymers that transparent therefore compatible with optical imaging techniques. The manufactured using combination microfabrication inkjet printing techniques flexible, allowing better adherence to brain’s natural curvature. We characterized properties electrode evaluated its performance an anesthetized mouse. Furthermore, combined experimental data finite-element model in-vivo setup estimate maximum electric highly can generate mouse brain. Our findings indicate high 300 V/m, demonstrating potential studying manipulating range relevant human applications. Overall, work presents promising approach developing versatile new tools apply study stimulation.

Language: Английский

Citations

0