ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(46), P. 64297 - 64306
Published: Nov. 8, 2024
Alzheimer's
disease
(AD)
is
a
widely
prevalent
neurodegenerative
condition
globally,
arousing
significant
interest
in
the
noninvasive
early
detection
of
disease.
The
concentration
amyloid
β
(Aβ)
biomarkers
blood
closely
linked
to
progression
AD,
emphasizing
importance
developing
precise
method
for
detecting
these
samples
diagnosis.
In
this
study,
we
developed
ratiometric
electrochemical
aptamer-based
(EAB)
biosensor
accurate
Aβ42
and
Aβ40.
utilizes
gold
nanoparticle
(AuNPs)
modified
electrode
through
an
deposition
assay
self-assembled
poly-A
based
U-shaped
structure
achieve
signal
changes
competitive
binding
target
molecules.
Importantly,
using
calibration
clipping
reference
probe,
proposed
displayed
ability
Aβ40,
with
limits
59
21
pM,
respectively.
It
also
has
great
stability
anti-interference
complex
biological
samples.
Furthermore,
it
demonstrated
satisfactory
performance
Aβ
peptides
20%
FBS
sample,
recoveries
ranging
from
96.7%
102.2%
serum
samples,
relative
standard
deviations
(RSD)
3.3%
8.9%.
Moreover,
expected
directly
quantify
Aβ42/Aβ40
ratio
by
introducing
suitable
providing
potential
effective
tool
diagnosis
AD.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(15)
Published: Feb. 22, 2024
Abstract
Amyloid
beta‐protein
(AβA
β
)
is
a
main
hallmark
of
Alzheimer's
disease
(AD),
and
low
amount
Aβ
protein
accumulation
appears
to
be
potential
marker
for
AD.
Here,
an
electrochemical
DNA
biosensor
based
on
polyamide/polyaniline
carbon
nanotubes
(PA/PANI‐CNTs)
developed
with
the
aim
diagnosing
AD
early
using
simple,
low‐cost,
accessible
method
rapidly
detect
Aβ42
in
human
blood.
Electrospun
PA
nanofibers
served
as
skeleton
successive
situ
deposition
PANI
CNTs,
which
contribute
both
high
conductivity
abundant
binding
sites
aptamers.
After
aptamers
are
immobilized,
this
aptasensor
exhibits
precise
specific
detection
blood
within
only
4
min
extremely
fast
response
rate,
lower
limit,
excellent
linear
range.
These
findings
make
significant
contribution
advancing
development
serum‐based
techniques
Aβ42,
thereby
paving
way
improved
diagnostic
capabilities
field
Chemosensors,
Journal Year:
2025,
Volume and Issue:
13(4), P. 146 - 146
Published: April 16, 2025
The
development
of
cost-effective,
rapid-response,
and
user-friendly
biosensing
platforms
has
become
paramount
importance
for
achieving
precise
biomarker
quantification
in
early
disease
detection.
Implementing
timely
diagnostic
interventions
through
accurate
analysis
not
only
significantly
improves
treatment
outcomes
but
also
enables
effective
management
strategies,
ultimately
leading
to
substantial
reductions
patient
mortality
rates.
These
clinical
imperatives
have
consequently
driven
the
innovation
portable
point-of-care
(POC)
systems.
Electrochemical
biosensors
are
attractive
diagnosis
diseases
due
their
low
cost,
simple
operation,
high
sensitivity.
This
review
examines
prevalent
material
innovations
electrode
functionalization
electrochemical
platforms,
with
specific
emphasis
on
translational
applications
early-stage
included
three
important
types:
proteins,
nucleic
acids,
small
molecule
metabolites.
Furthermore,
work
proposes
novel
research
trajectories
next-generation
biosensor
development,
advocating
synergistic
integration
artificial
intelligence-driven
analytics,
Internet
Medical
Things
(IoMT)-enabled
networks,
advanced
micro/nanofabrication
techniques.
Polymers for Advanced Technologies,
Journal Year:
2025,
Volume and Issue:
36(5)
Published: May 1, 2025
ABSTRACT
Nanofiber‐based
drug
delivery
systems
show
strong
potential
due
to
their
high
surface
area‐to‐volume
ratio
and
adjustable
structure.
Recent
studies
demonstrated
loading
efficiencies
exceeding
85%,
with
sustained
release
kinetics
up
96
h.
In
cancer
models,
nanofiber‐based
carriers
improved
accumulation
at
tumor
sites
by
3–4
fold
compared
conventional
formulations,
enhancing
therapeutic
efficacy
minimizing
systemic
toxicity.
This
review
outlines
methods
for
precise
nanofiber
shape
function
control
through
electrospinning
solution
blow
spinning
techniques.
advancements
in
technology
have
proven
promising
biomedical
applications
where
they
are
utilized
tissue
engineering,
neurodegenerative
disease
management,
wound
healing,
targeted
therapy.
Nanofibers
as
an
optimal
system
that
improves
cellular
restoration,
together
controlled
deep
penetration
capabilities.
The
recent
development
of
dual‐drug
systems,
stimuli‐responsive
nanofibers,
scaffolds
composed
nanofibers
smart
materials
has
expanded
usage
precision
medicine.
Research
now
demonstrates
facilitate
remodeling
functions
along
angiogenesis
promotion,
inflammatory
response
stability
improvement.
also
focuses
on
the
patents
a
system.
addition,
this
presents
new
approaches
overcome
these
challenges
based
interdisciplinary
cooperation,
AI‐driven
design
such
sophisticated
bioinformatics
tools.
review,
advances
prospects
realizing
revolution
field
improving
healthcare
outcomes
presented
detailed
overview.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 22, 2025
Abstract
Viral
hepatitis
is
a
highly
infectious
disease
caused
by
various
viruses
that,
thus
far,
have
no
cure.
In
early
viral
invasion,
low
load
in
the
blood
makes
detection
difficult
unless
symptoms
are
severe.
Herein,
new
ultrasensitive
and
ultrafast
virus
strategy
proposed
constructing
dual‐surface‐activated
nanotube
that
enables
recognition
probes
to
not
only
bind
outer
surface
of
but
also
penetrate
lock
onto
its
inner
surface.
This
approach
significantly
enhances
both
specific
area
number
active
sites,
thereby
improving
capture
efficiency
for
traces
DNA,
such
as
B
type
(HBV‐DNA).
Compared
with
current
DNA
methods,
this
eliminates
additional
amplification
steps
achieve
an
ultralow
limit
10
−18
m
,
advancing
available
time
possible.
Using
human
serum
sample,
technique
precise
quantitative
reporting
HBV‐DNA
within
15
min
overcomes
interference
usual
proteins
other
DNA.
provides
inspiration
quick
diagnosis
in‐hospital
non‐hospital
patients
without
bulky
instruments
complex
operations.
Biosensors and Bioelectronics X,
Journal Year:
2024,
Volume and Issue:
20, P. 100528 - 100528
Published: Aug. 8, 2024
Neurodegenerative
diseases
(NDs)
have
been
a
group
of
disorders
characterized
by
neuronal
death
and
functional
loss
including
Alzheimer's
disease
(AD),
Parkinson's
(PD)
Huntington's
(HD),
etc.
Since
diagnostic
methods
for
the
NDs
biomarkers
based
on
traditional
enzyme
linked
immunosorbent
assay
(ELISA)
or
Western
Blotting,
antibody
intrinsic
drawbacks
such
as
large
molecular
weight
high
cost
make
early
diagnosis
quite
challenging.
The
aptamers
bridge
this
gap
effectively
their
versatile
features
small
weight,
easy
modification,
stability
low
widely
used
to
fabricate
biosensors
diagnose
NDs.
Various
aptamer-based
shown
excellent
performance
in
Several
nucleic
acid,
protein,
biomolecule,
exosome
has
indicators
In
minireview,
we
aim
report
latest
progress
aptasensors
(including
colorimetric,
fluorescence,
electrochemical
electrochemiluminescence,
etc)
detecting
protein
biomarkers,
summarize
principles
functions
along
with
challenges
way
emphasize
future
perspectives.
•
Review
neurodegenerative
Discuss
advantages
disadvantages
Limitations
conventional
were
also
discussed.
Point
out
gaps
aptamer
guided
research
direction
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 12, 2024
This
review
evaluated
electrocorticography
(ECoG)
electrode
performance
based
on
key
properties
and
improvements
from
polymers,
categorizing
them
as
sensitive
or
structural,
while
discussing
preparation
methods,
challenges,
future
perspectives.
