A novel silkworm excrement-derived nanomedicine integrating ferroptosis and photodynamic therapy, well-suitable for PD-L1-mediated immune checkpoint blockade

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 505, P. 159676 - 159676

Published: Jan. 17, 2025

Language: Английский

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Convertible ROS Nanogenerator/Eliminator for Enhanced Tumor Photothermal Therapy with Reduced Inflammatory Response

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Abstract Photothermal therapy (PTT), as an innovative optical tumor treatment strategy, is characterized by its minimal invasiveness, high selectivity, long‐lasting efficacy, and safety, has attracted widespread attention. However, in order to effectively kill cancer cells, a higher local temperature very necessary, which inevitably results severe stress responses cell death, thereby triggering harmful inflammation. Additionally, achieving effective controlled release of drugs the microenvironment reduce systemic side effects still major challenge. Herein, intelligent nanoplatform first reported, featured sulfide iron (FeS) nanosheets core, loaded with perfluorohexane (PFH), skillfully coated polydopamine (PDA). It can serve generator reactive oxygen species (ROS) induce ferroptosis, further intensifying PTT, ROS eliminator normal tissue control undesired inflammatory response during differential strategy between surrounding tissue. Meanwhile, combination ultrasound‐targeted microbubble destruction (UTMD) technology significantly enhanced penetration drug. Overall, delivery FeS/PFH@PDA combined UTMD achieve precise efficient synergistic for tumors demonstrate outstanding ultrasound MR dual‐mode imaging performance.

Language: Английский

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Tracking In Vivo Lipolysis of Lipid Nanocarriers Using NIR‐II Polarity‐Sensitive Fluorescent Probes

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Abstract Elucidating in vivo lipolysis is crucial for clarifying the underlying mechanisms and fates of lipid‐based nanocarriers, which are essential oral drug delivery carriers. Current mainstream methodologies use various vitro digestion models to predict performance lipid formulations; however, their accuracy often impeded by complicated environment gastrointestinal tract. Although fluorescence labeling with conventional probes partly reveals translocation it fails elucidate process because poor signal discrimination among free probes, mixed micelles (lipolysis end‐products). Here, a polarity‐sensitive probe (PN‐C18) aggregation‐caused quenching properties nanocarriers developed optimized. PN‐C18 successfully eliminates interference from both during lipolysis. In representative model, shows stronger correlation between intensity progression than those previous methods. vivo, nanoparticles clearly visualized effectively monitored, owing high tissue‐penetrating capability NIR‐II photons. This study provides practical means elucidating fate systems offers valuable insights reference further studies this domain.

Language: Английский

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Self-assembled hyaluronic acid nanomicelle for enhanced cascade cancer chemotherapy via self-sensitized ferroptosis

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 343, P. 122489 - 122489

Published: July 14, 2024

Language: Английский

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Overcoming Photothermal Resistance of Gastric Cancer by Bionic 2D Iron-Based Nanoplatforms with Precise CRISPR/Cas9 Delivery

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

The development of new CRISPR/Cas9 delivery systems with a synergistic therapeutic mode can provide perspective for efficient tumor treatment. In this work, we developed bionic 2D FeS nanoplatform high loading (FCRM), highlighting the synergy and ferroptosis in regulating heat shock proteins (HSPs) enhanced photothermal therapy (PTT). Due to ultrathin structure pH-response nanosheets, FCRM quickly decompose microenvironment effectively release Fe2+, which be further by process. accurately downregulate level intracellular antiapoptosis protein Survivin. Fe2+ induce lipid peroxidation cells. Ferroptosis regulation Survivin synergistically expression HSPs, thereby reducing resistance cells PTT. Additionally, caused significant magnetic resonance contrast enhancement, aided accurate diagnosis tumors. Therefore, has great potential achieving targeted imaging dual HSPs ferroptosis-gene

Language: Английский

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Molecularly engineering a lipid nanoregulator destroying the last defense of ferroptosis in breast cancer therapy

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 495, P. 153366 - 153366

Published: June 20, 2024

Language: Английский

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Therapeutic types and advantages of functionalized nanoparticles in inducing ferroptosis in cancer therapy

Annals of Medicine, Journal Year: 2024, Volume and Issue: 56(1)

Published: Sept. 14, 2024

The clinical efficacy of cancer treatment protocols remains unsatisfactory; however, the emergence ferroptosis-driven therapy strategies has renewed hope for tumor treatment, owing to their remarkable suppression effects. Biologically based small-molecule inducers are used in conventional method induce ferroptosis. Nevertheless, some molecular drugs have limited solubility, poor ability target cells, and fast metabolism, which hinder ferroptosis over a prolonged period. Fortunately, further investigations development nanotechnology demonstrated that nanoparticles (NPs) more efficient inducing than alone, opens up new perspectives therapy.

Language: Английский

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Oxygen-boosted fluorinated prodrug hybrid nanoassemblies for bidirectional amplification of breast cancer ferroptosis

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 377, P. 619 - 631

Published: Nov. 29, 2024

Language: Английский

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