Docetaxel‐Encapsulated Catalytic Pt/Au Nanotubes for Synergistic Chemo‐Photothermal Therapy of Triple‐Negative Breast Cancer

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(29)

Published: Aug. 27, 2024

The combination of photothermal therapy with chemotherapy has emerged as a promising therapeutic modality for addressing triple-negative breast cancer (TNBC). This manuscript describes novel hybrid nanoplatform comprising ultrathin catalytic platinum/gold (Pt/Au) nanotubes encapsulated docetaxel and phase-change materials (PCMs) the photoacoustic imaging-guided synergistic chemo-photothermal TNBC. Upon irradiation near-infrared laser, heating converts solid-state PCM into liquid, triggering controlled release docetaxel. thin Pt layer within enhances nanotube's thermal stability, thus prolonging ablation tumors. Furthermore, platinum effectively mitigates tumor hypoxia by catalyzing decomposition hydrogen peroxides to generate oxygen in microenvironment, improving efficiency chemotherapy. It is demonstrated that drug-loaded achieve significant inhibition rates 75.4% vivo on 4T1 tumor-bearing mice, significantly surpassing control groups. These also notably extend survival, attributable effects prolonged facilitated oxygenation-enhanced leverages unique properties Pt/Au NTs-DTX/PCM nanoplatform, optimizing outcomes. envisioned this may find important applications managing superficial malignant solid tumors general.

Language: Английский

Multifunctional Theranostic Glyconanoprobes for Synergistic Eradication of Breast Cancer

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 24, 2024

The development of multifunctional theranostic glyconanoprobes for breast cancer is distinguished by their tumor-targeting capability and enhanced antitumor efficacy, achieved through synergistic chemo-gene photothermal therapy.

Language: Английский