Engineering of Nanofibers Embedded with Targeted Nanoparticles Breaks Redox Levers for Glioblastoma Therapy DOI
Yuan Ma, Mengqi Li, Xiao Fu

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Abstract Glioblastoma multiforme (GBM), one of the most aggressive brain cancers, presents substantial therapeutic challenges, particularly concerning postsurgical recurrence and inherent drug resistance. In this study, a nanofiber‐based delivery system integrating platinum pro‐drugs hemoglobin into mesoporous silica nanoparticles (HB/HSPt@MS NPs) is reported, which are surface‐modified with poly(ethylene glycol) (PEG) targeting molecules, subsequently embedded nanofibers using an electrostatic spinning approach. Applied to tumor site, these leverage folate receptor overexpression on tumor's redox state enable precise release, inducing cell death through targeted resistance pathway. The incorporation crucial as it disrupts balance within GBM cells by facilitating influx iron ions, leading lipid peroxidation Fenton reaction. This induces oxidative stress overwhelms cellular antioxidant mechanisms. dual mechanism action—direct cytotoxicity sustained release indirect induced stress—enhances efficacy drugs. effectively bypasses blood‐brain barrier reduces systemic toxicity, significantly improving efficacy. Both in vitro vivo evaluations demonstrate inhibition growth recurrence, highlighting potential for personalized therapy.

Language: Английский

Magnetic mesoporous silica nanoparticles as advanced polymeric scaffolds for efficient cancer chemotherapy: recent progress and challenges DOI Creative Commons
Sara Payamifar,

Yasaman Khalili,

Amin Foroozandeh

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(20), P. 16050 - 16074

Published: Jan. 1, 2025

Magnetic mesoporous silica nanoparticles stand out as excellent options for targeted chemotherapy owing to their remarkable features.

Language: Английский

Citations

0
Engineering of Nanofibers Embedded with Targeted Nanoparticles Breaks Redox Levers for Glioblastoma Therapy DOI
Yuan Ma, Mengqi Li, Xiao Fu

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Abstract Glioblastoma multiforme (GBM), one of the most aggressive brain cancers, presents substantial therapeutic challenges, particularly concerning postsurgical recurrence and inherent drug resistance. In this study, a nanofiber‐based delivery system integrating platinum pro‐drugs hemoglobin into mesoporous silica nanoparticles (HB/HSPt@MS NPs) is reported, which are surface‐modified with poly(ethylene glycol) (PEG) targeting molecules, subsequently embedded nanofibers using an electrostatic spinning approach. Applied to tumor site, these leverage folate receptor overexpression on tumor's redox state enable precise release, inducing cell death through targeted resistance pathway. The incorporation crucial as it disrupts balance within GBM cells by facilitating influx iron ions, leading lipid peroxidation Fenton reaction. This induces oxidative stress overwhelms cellular antioxidant mechanisms. dual mechanism action—direct cytotoxicity sustained release indirect induced stress—enhances efficacy drugs. effectively bypasses blood‐brain barrier reduces systemic toxicity, significantly improving efficacy. Both in vitro vivo evaluations demonstrate inhibition growth recurrence, highlighting potential for personalized therapy.

Language: Английский

Citations

1