CRISPR-based genetically modified scaffold-free biomaterials for tissue engineering and regenerative medicine DOI

Yunxuan Chen,

Yu Ke, Zhiwei Jiang

et al.

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review focuses on CRISPR-based genetically modified extracellular vehicles, cell sheets, aggregates, organoids, and organs, elaborating their applications future directions in tissue engineering regenerative medicine.

Language: Английский

Recent studies of the effects of microgravity on cancer cells and the development of 3D multicellular cancer spheroids DOI Creative Commons
Daniela Grimm, Thomas J. Corydon, Jayashree Sahana

et al.

Stem Cells Translational Medicine, Journal Year: 2025, Volume and Issue: 14(3)

Published: March 1, 2025

Abstract The still young and developing space age, characterized by lunar Martian exploration the vision of extraterrestrial settlements, presents a unique environment to study impact microgravity (µg) on human physiology disease development. Cancer research is currently key focus international science, as µg fundamentally impacts cellular processes like differentiation, adhesion, migration, proliferation, survival, cell death, or growth cancer cells well cytoskeleton extracellular matrix (ECM). By creating three-dimensional (3D) tumor models in µg-environment, multicellular spheroids (MCS), researchers can expedite drug discovery development, reducing need for animal testing. This concise review analyses latest knowledge influence MCS formation. We will from brain tumors, lung, breast, thyroid, prostate, gastrointestinal, skin exposed real (r-) simulated (s-) µg-conditions.

Language: Английский

Citations

0
Microfluidic manipulation of the multicellular spheroids and organoids for modeling human diseases DOI
Liang Zhao, Shan Xiong, Dan Wang

et al.

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113718 - 113718

Published: April 1, 2025

Language: Английский

Citations

0
One-step spheroid formation via double-emulsion drops generated by a glass capillary-based microfluidic device for circadian rhythm investigation DOI

Hye‐Seon Jeong,

Chaehee Park, Chang‐Soo Lee

et al.

Biotechnology and Bioprocess Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 15, 2025

Language: Английский

Citations

0
CRISPR-based genetically modified scaffold-free biomaterials for tissue engineering and regenerative medicine DOI

Yunxuan Chen,

Yu Ke, Zhiwei Jiang

et al.

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review focuses on CRISPR-based genetically modified extracellular vehicles, cell sheets, aggregates, organoids, and organs, elaborating their applications future directions in tissue engineering regenerative medicine.

Language: Английский

Citations

0