A comprehensive review of additively manufactured biomedical titanium-based alloys for bone tissue engineering: Biocorrosion, biomechanical, and biological properties

Journal of Materials Research and Technology, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

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Biomechanics and Mechanobiology of Additively Manufactured Porous Load‐Bearing Bone Implants

Small, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Abstract Given that they can replicate both the biomechanical and mechanobiological functions of natural bone, metal additively manufactured porous load‐bearing bone implants present a significant advancement in orthopedic applications. Additive manufacturing (AM) metals enables precise control over pore geometry, resulting provide effective mechanical support minimize stress shielding. In addition to its benefits, architecture facilitates essential processes, including transmission signals regulate cellular processes such as adhesion, proliferation, differentiation. Before clinical use, should first be engineered achieve comparable elastic modulus native mitigating implant‐induced resorption while promoting tissue regeneration. It is also noteworthy microstructural features these angiogenesis‐a critical process for oxygen nutrient delivery during healing. Despite their potential challenges remain balancing stability applications with biofunctionality integration controlled degradation. This review comprehensively discusses factors influencing design performance implants, highlighting enhance outcomes repair

Language: Английский

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Macrophage Membrane‐Biomimetic Multi‐Layered Nanoparticles Targeting Synovial Angiogenesis for Osteoarthritis Therapy

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 14, 2024

Abstract Osteoarthritis (OA) is an inflammatory and progressive joint disease characterized by angiogenesis‐mediated sustained, chronic, low‐grade synovitis. Anti‐angiogenesis emerging as a strategy for attenuating OA progression, but often compromised poor targeted drug delivery immune clearance. Recent studies have identified macrophages formed “protective barrier” in the lining layer (LL) of synovium, which blocked communication cavity sublining (SL) synovium. Inspired natural mimicry, macrophage membrane‐camouflaged explored to avoid Based on single cell RNA sequencing, CD34 + synovial cells are “sentinel cells” synovium angiogenesis. Consequently, antibody‐modified membrane constructed target new Hence, biomimetic multi‐layered nanoparticle (NP) developed that incorporates axitinib‐loaded poly(lactic‐co‐glycolic) acid (PLGA) with antibody modified (Atb@NP@Raw@CD34) specifically deliver axitinib (Atb) SL sustain inhibiting angiogenesis without elimination. It found Atb@NP@Raw@CD34 can pass through “barrier”, targeting cells, continuously releasing Atb anti‐angiogenesis Furthermore, vivo data demonstrated attenuate degeneration In conclusion, local injection presents promising approach clinically impeding progression.

Language: Английский

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Biomineralized PEEK cages containing osteoinductive CaP bioceramics promote spinal fusion in goats

Bioactive Materials, Journal Year: 2024, Volume and Issue: 45, P. 128 - 147

Published: Nov. 20, 2024

Language: Английский

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