Atomically Engineered Chlorine Coordination of Iron in Active Centers for Selectively Catalytic H₂O₂ Decomposition Toward Efficient Antitumor‐Specific Therapy

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Abstract The intervention of endogenous H 2 O via nanozymes provides a potential antitumor‐specific therapy; however, the role nanozyme structure in relation to selective decomposition hydroxyl radicals (•OH) is yet be fully understood, which limits development this therapeutic approaches. Herein, an iron single‐atom (Fe─N Cl ─C SAzyme) reported, prepared through precise Fe─Cl coordination based on construction characteristic Fe‐containing molecule. Fe─N exhibits efficient catalytic (2.19 × 10 6 m −1 s ), highest among reported SAzymes. More importantly, it found that selectively decomposed into •OH surface, attributable d orbitals Fe active center matching O‐2 p electrons adsorbed hydroxide (*OH) intermediate. strongly cytotoxic toward variety cancer‐cell lines vitro but not normal cells. Furthermore, shows outstanding specific effect vivo; efficiently destroys solid malignant tumors without injuring tissue. Altogether, these findings highlight •OH, achieved by engineering atomic level, thereby providing avenue for nanomedicines with antitumor activities.

Language: Английский

Inhibition of Malignant Pleural Effusion by a Physiological Intrapleural Pressure-controlled Piezo-catalytic Nanozyme System

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

Malignant pleural effusion (MPE), persistently generated thorax tumor cells at advanced stage, remains a major challenge for cancer therapy. Herein, we develop an ultra-sensitive piezoelectric nano-system by doping ytterbium in metal-organic framework (O₃P@LPYU), which can be triggered physiological intrapleural pressures during breath. Under the gently alterative pressure, nanoparticles produce burst of reactive oxygen species and induce immunogenic cell death catalysis carried ozone as well peroxide interstitial fluid. A clear biodistribution is observed tumors upon administration particle. Remarkably, due to abundant substrate oxygen-rich environment cavity, O₃P@LPYU particle provides potently reduction MPE volume durable inhibition growth lung parenchyma. In conclusion, our work not only develops bio-responsive nano system, but also strategy persistent suppression clinics.

Language: Английский