A Spiro‐Based NIR‐II Photosensitizer with Efficient ROS Generation and Thermal Conversion Performances for Imaging‐Guided Tumor Theranostics

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Abstract Organic photosensitizers (PSs) possessing NIR‐II emission and photodynamic/photothermal effect have received a great sense of attention for their cutting‐edge applications in imaging‐guided multimodal phototherapy. However, it is highly challenging to design efficient PSs with high luminescence phototherapy performance simultaneously. In this study, spiro‐functionalization strategy proposed alleviate aggregate‐caused quenching promote photodynamic therapy, the verified via spiro[fluorine‐9,9ʹ‐xanthene]‐modified PS (named SFX‐IC) an acceptor–donor–acceptor configuration. SFX‐IC‐based nanoparticles (NPs) display molar extinction coefficient 7.05 × 10 4 m ‒1 cm −1 at 645 nm due strong intramolecular charge‐transfer characteristics. As expected, as‐prepared NPs show fluorescence quantum yield 1.1%, thanks spiro‐configuration that suppressing excessively intermolecular π–π stacking. Furthermore, SFX‐IC not only efficiently generate 1 O 2 ∙− under 660 laser irradiation, but also possess good photothermal conversion efficiency 47.14%. Consequently, can be served as versatile phototheranostic agents fluorescence/photoacoustic phototherapy, manifesting spiro‐functionalized powerful tool construct emitting PSs.

Language: Английский

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Pyrrolopyrrole Cyanine-Based Polymer with Superior Multifunctionality for Boosting Cancer Phototheranostics

ACS Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 1431 - 1439

Published: March 19, 2025

Molecular agents with exceptional multifunctionality are highly sought for phototheranostic applications. Herein we present a high-performance polymer near-infrared II (NIR-II) fluorescence and photoacoustic (PA) imaging-guided mild photothermal therapy (mPTT) of tumors. We synthesize series semiconducting polymers based on pyrrolopyrrole cyanine, identifying that P(P-T) exhibits large mass extinction coefficient (139 L g–1 cm–1), excellent performance, bright NIR-II fluorescence, PA imaging signals, making it among the highest-performing in these properties. A tumor-targeting agent was developed by coencapsulating heat shock protein (HSP) inhibitor camouflaging M1 macrophage membranes. The integration enables comprehensive tumor site delineation, guiding subsequent therapeutic intervention. In 4T1 tumor-bearing mice, synergistic effect mPTT under low-power 808 nm laser irradiation, combined HSP inhibition, resulted significant suppression. This work offers valuable insights designing advanced agents.

Language: Английский

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Applications of Nanotheranostic in the Second Near-Infrared Window in Bioimaging and Cancer Treatment

Nanoscale, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Achieving accurate and efficient tumor imaging is crucial in the field of treatment, as it facilitates early detection precise localization tissues, thereby informing therapeutic strategies surgical interventions. The optical technology within second near-infrared (NIR-II) window has garnered significant interest for its remarkable benefits, such enhanced tissue penetration depth, superior signal-to-background ratio (SBR), minimal autofluorescence, reduced photon attenuation, lower scattering. This review explained design optimization nano-agents responsive to NIR-II window, single-walled carbon nanotubes, quantum dots, lanthanum-based nanomaterials, noble metal nanomaterials. These enable non-invasive, deep-tissue with high spatial resolution their properties significantly improve accuracy, efficiency, versatility imaging-guided treatments. And we discussed characteristics advantages fluorescence (FL)/photoacoustic (PA) providing a comprehensive overview latest research progress different FL/PA therapy. Furthermore, exhaustively reviewed applications multifunctional nano-phototherapy technologies carried out by light including photothermal therapy (PTT), photodynamic (PDT), combined modalities like photothermal-chemodynamic (PTT-CDT), photothermal-chemotherapy (PTT-CT), photothermal- immunotherapy (PTT-IO). integrated approaches have gradually matured over past decade are expected become safe effective non-invasive treatment. Finally, outlined prospects challenges development innovation diagnosis nanoplatform. aims provide insightful perspectives future advancements treatment platforms.

Language: Английский

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Photovoltaic Molecule‐Based Phototheranostics With A‐D‐A Structure for Near‐Infrared Fluorescence Imaging‐Guided Synergetic Photodynamic and Photothermal Therapy of Tumors

Luminescence, Journal Year: 2024, Volume and Issue: 39(10)

Published: Oct. 1, 2024

ABSTRACT Phototheranostics with near‐infrared fluorescence and reactive oxygen species generation ability high photothermal conversion efficiency (PCE) plays a significant role in imaging‐guided synergetic photodynamic therapy of tumors. Here, star molecule organic photovoltaic materials, NCBDT‐4C an A‐D‐A conjugated structure, was assembled DSPE‐PEG‐NH 2 to prepare water dispersive nanoparticles (NPs). The prepared NCBDT‐4Cl NPs exhibited maximum NIR absorption peak at 764 nm 798 nm. These could generate superoxide anion, singlet ( 1 O ), heat under 808 laser irradiation. quantum yield PCE the were 37.5% 53.6%, respectively. combination cancer demonstrated vitro vivo. This work presents advanced application materials phototherapy.

Language: Английский

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Gas Empowered Dual‐Cascade Strategy for Augmented Single‐Atom Nanotherapies

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Abstract Single‐atom nanotherapies have received numerous attention in malignant oncotherapy. However, the insufficient enzyme substrate and upregulation of heat shock proteins during therapeutic interventions are seldom concurrently noticed. Herein, a novel gas empowered dual‐cascade synergistic treatment strategy is demonstrated with domino effect, which can sequentially reinforce single‐atom nanozyme (SAzyme)‐based enzymatic therapeutics mild photothermal therapy (PTT) (< 45 °C). In proof‐of‐concept study, Fe single atom (Fe/SAzyme) loaded hydrogen sulfide (H 2 S) donor NaHS developed for HSPs‐silencing mediated PTT. The generated H S suppresses catalase activity to achieve “intracellular O conservation”, thereby furnishing Fe/SAzyme produce abundant cytotoxic hydroxyl radicals (·OH) augmented therapeutics. Then, excess ·OH induced mitochondrial dysfunction blocks adenosine triphosphate (ATP) energy supply realize cellular remodeling, hinders overexpression HSPs enhances PTT both vitro vivo. Consequently, gas‐triggered achieves S/·OH/mitochondrial endowing SAzymes maximum antitumor efficacy via combined This dual‐cascaded gas/enzymatic/mild oncotherapy not only exhibits new pathway gas‐facilitated PTT, but also offers valuable paradigm application “1 + 1 > 3” multimodal tumor therapy.

Language: Английский

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