Endoplasmic reticulum stress in acute lung injury and pulmonary fibrosis DOI
Zhiheng Sun,

Wanyu He,

Huiwen Meng

et al.

The FASEB Journal, Journal Year: 2024, Volume and Issue: 38(23)

Published: Dec. 9, 2024

Abstract Pulmonary fibrosis (PF) is a progressive and irreversible lung disease that leads to diminished function, respiratory failure, ultimately death typically has poor prognosis, with an average survival time of 2 5 years. Related articles suggested endoplasmic reticulum (ER) stress played critical role in the occurrence progression PF. The ER responsible for maintaining protein homeostasis. However, factors such as aging, hypoxia, oxidative stress, or inflammation can disrupt this balance, promoting accumulation misfolded proteins triggering stress. To cope situation, cells activate unfolded response (UPR). Since acute injury (ALI) one key onset events PF, review, we will discuss ALI PF by activating multiple signaling pathways molecular mechanisms affect function behavior different cell types, focus on epithelial cells, fibroblasts, macrophages. Linking these types may broaden our understanding underlying help us target through mechanisms. relationship between still evolving, future research explore new strategies regulate UPR pathways, providing novel therapeutic targets.

Language: Английский

Tailoring functionalities: pore engineering strategies in porous organic cages for diverse applications DOI

Mingming Hua,

Yang Ding, Chunxiao Lv

et al.

Journal of Materials Chemistry A, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

This review focuses on pore engineering (intrinsic size, extrinsic porosity, and environment) in porous organic cages summarizes the roles of various fields.

Language: Английский

Citations

3
Endoplasmic reticulum stress in acute lung injury and pulmonary fibrosis DOI
Zhiheng Sun,

Wanyu He,

Huiwen Meng

et al.

The FASEB Journal, Journal Year: 2024, Volume and Issue: 38(23)

Published: Dec. 9, 2024

Abstract Pulmonary fibrosis (PF) is a progressive and irreversible lung disease that leads to diminished function, respiratory failure, ultimately death typically has poor prognosis, with an average survival time of 2 5 years. Related articles suggested endoplasmic reticulum (ER) stress played critical role in the occurrence progression PF. The ER responsible for maintaining protein homeostasis. However, factors such as aging, hypoxia, oxidative stress, or inflammation can disrupt this balance, promoting accumulation misfolded proteins triggering stress. To cope situation, cells activate unfolded response (UPR). Since acute injury (ALI) one key onset events PF, review, we will discuss ALI PF by activating multiple signaling pathways molecular mechanisms affect function behavior different cell types, focus on epithelial cells, fibroblasts, macrophages. Linking these types may broaden our understanding underlying help us target through mechanisms. relationship between still evolving, future research explore new strategies regulate UPR pathways, providing novel therapeutic targets.

Language: Английский

Citations

2