Advancements in nanozymes research for the management of chronic wounds

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 500, P. 157299 - 157299

Published: Nov. 1, 2024

Language: Английский

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Hybrid hydrogel loaded with natural plant extract accelerates diabetic wound healing via ROS scavenging and immunoregulation

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 156388 - 156388

Published: Oct. 1, 2024

Language: Английский

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Regulator of oxidative balance: Research progress of nanozymes in ROS-related diseases

Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 44, P. 102540 - 102540

Published: Jan. 22, 2025

Language: Английский

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Dual ROS/Glucose-Responsive Quercetin-Loaded Supramolecular Hydrogel for Diabetic Wound Healing

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Diabetic wound healing remains a significant challenge due to complex pathological mechanisms, including prolonged inflammation, excessive reactive oxygen species (ROS) accumulation, angiogenesis dysfunction, and increased susceptibility bacterial infection. In this study, we developed dual ROS/glucose-responsive quercetin-loaded supramolecular hydrogel (GPQ hydrogel) for treating diabetic wounds. The was fabricated by incorporating quercetin (QUE) into guanosine–phenylboronic acid (GP) network through dynamic borate ester bonds. Structural characterization revealed the formation of typical G-quadruplex structure in GPQ hydrogel. responsiveness ROS glucose enabled controlled release QUE, effectively addressing abnormal microenvironment diabetes. vitro studies demonstrated excellent antibacterial, antioxidant, anti-inflammatory, pro-angiogenic properties Furthermore, vivo study using full-thickness model streptozotocin-induced rats showed that significantly accelerated closure, enhanced re-epithelialization collagen deposition, promoted compared control GP groups. Immunofluorescence analysis confirmed superior antioxidant effects microenvironment. This presents promising multifunctional biomaterial managing

Language: Английский

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Prussian blue nanohybrid hydrogel combined with specific far-infrared based on graphene devices for promoting diabetic wound healing

Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113839 - 113839

Published: March 1, 2025

Language: Английский

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Prodigiosin Loaded SN‐PB@PG NPs‐Based Multimodal Therapy for the Healing of Bacterial Infected Chronic Wounds

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 23, 2025

Abstract Healing of infected chronic wounds faces dual challenges: persistent inflammation and impaired angiogenesis. To address these, SN‐PB@PG nanocomplexes were prepared by hybridisation nitroprusside (SNP) with Prussian blue (SN‐PB NPs) loaded prodigiosin (PG). Under near‐infrared (NIR) irradiation, SN‐PB NPs generated mild hyperthermia, facilitating the release nitric oxide (NO) PG to combat bacterial biofilms multidrug‐resistant pathogens. The in vivo assay using diabetic demonstrated that NIR reduced wound area 10.6% 11th day, which is superior control group (29.6%). In flap transplantation experiments, data showed only have a necrobiosis 3.8% flaps on 8th 31.3% group. Additionally, NO promoted vascular regeneration up‐regulating endothelial growth factor (VEGF) platelet cell adhesion molecule‐1 (CD31), regenerated sarcomeric tissue down‐regulating MMP‐9. results indicated combination gas photothermal therapy exerted combined antibacterial healing effect. Compared traditional clinical methods such as surgical debridement hyperbaric oxygen therapy, this new strategy efficiently addresses issues infection healing, convenient for application.

Language: Английский

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Engineered Exudate Trap with Programmable Enrichment and Force‐Controlled Therapy Pump toward Diabetic Burn Personalized Treatment

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Abstract Personalized treatment is an effective approach that provides customized therapeutic regimens. However, existing personalized strategies often require complex designs, which are challenging to implement and susceptible failure. By virtue of the widespread mechanical environment in human body, a force‐controlled therapy pump reported for controlled release individualized therapy. Similar fish trap, composed hydrophobic trammel film with random microfibers, cover aligned inner hydrophilic sponge loaded bletilla striata polysaccharide‐confined nano cerium oxide (BCe). BCe possesses excellent reactive oxygen species (ROS) scavenging ability (, H 2 O , ·OH) due small particle size (2.6 ± 0.8 nm) high Ce 3+ ratio (66.19%). The trap programmatically enriches exudate enables through massage (0.1–1.38 N), achieving as pump. inflammatory phase shortened by blocking TNF NF‐κB signaling pathways, while activating PI3K‐AKT pathway associated cell migration angiogenesis. healing rate diabetic burn wounds (92.3%) surpasses commercial drug. This strategy suitable treatments mechanically induced environments, offering reference medicine.

Language: Английский

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Nanozymes as catalysts for accelerated healing of diabetic wounds

Published: April 1, 2025

Language: Английский

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Oxygenous and biofilm-targeted nanosonosensitizer anchored with Pt nanozyme and antimicrobial peptide in the gelatin/sodium alginate hydrogel for infected diabetic wound healing

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 293, P. 139356 - 139356

Published: Dec. 30, 2024

Language: Английский

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