Advances in the Treatment of Spinal Cord Injury with Nanozymes DOI
Zuohong Chen, Yili Wang,

Shaofang Zhang

et al.

Bioconjugate Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Spinal cord injury (SCI) with increasing incidence can lead to severe disability. The pathological process involves complex mechanisms such as oxidative stress, inflammation, and neuron apoptosis. Current treatment strategies focusing on the relief of stress inflammation have achieved good effects, while many problems challenges remain side effect short half-life therapeutic agents. Nanozymes exhibiting biocatalytic activities sustainably scavenge free radicals, inhibit neuroinflammation, protect neurons. With high stability in physiological conditions cost-effectiveness, nanozymes provide a new strategy for SCI treatment. In this Review, we outline advances their enzyme-mimicking highlight progress intervention SCI-adopting nanozymes. We also propose future directions clinical translation nanozyme against SCI.

Language: Английский

Advances in the Treatment of Spinal Cord Injury with Nanozymes DOI
Zuohong Chen, Yili Wang,

Shaofang Zhang

et al.

Bioconjugate Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Spinal cord injury (SCI) with increasing incidence can lead to severe disability. The pathological process involves complex mechanisms such as oxidative stress, inflammation, and neuron apoptosis. Current treatment strategies focusing on the relief of stress inflammation have achieved good effects, while many problems challenges remain side effect short half-life therapeutic agents. Nanozymes exhibiting biocatalytic activities sustainably scavenge free radicals, inhibit neuroinflammation, protect neurons. With high stability in physiological conditions cost-effectiveness, nanozymes provide a new strategy for SCI treatment. In this Review, we outline advances their enzyme-mimicking highlight progress intervention SCI-adopting nanozymes. We also propose future directions clinical translation nanozyme against SCI.

Language: Английский

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