Bioinspired micro‐ and nanostructured systems for cancer therapy DOI Creative Commons
Ruizhen Yang, Bing Zhang,

Xiawei Fei

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(12)

Published: Nov. 28, 2024

Abstract Numerous organisms in nature have demonstrated enhanced biocompatibility, precise tumor targeting capabilities, and efficient tissue traversal within the human body. Drawing inspiration from these organisms, researchers employed bioengineering, bioconjugation, micro‐ or nanotechnology to fabricate bioinspired nanostructured systems. These systems play a crucial role addressing limitations of conventional anticancer drugs nanomaterials concerning effective penetration physiological barriers, as well selective targeting, thereby leading improved therapeutic efficacy while minimizing nonspecific adverse effects on healthy cells. Consequently, extensive exploration has been undertaken across various cancer treatment modalities with some progressing into preclinical clinical stages. However, our understanding this field remains limited which may impede research progress, translation efforts, practical applications. Therefore, study presents systematic classification for therapy that comprehensively elucidates their sources design principles. Furthermore, it extensively discusses current status efforts identifying prevailing challenges exploring future prospects. This work will establish robust theoretical framework serve valuable reference facilitate advancements application field.

Language: Английский

TREM2 scFv‐Engineering Escherichia coli Displaying Modulation of Macrophages to Boost Cancer Radio‐Immunotherapy DOI Open Access
Yifan Wang, Anqi Dong,

Jianping Man

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Abstract Preoperative neoadjuvant radio‐chemotherapy is a cornerstone in the treatment of low rectal cancer, yet its effectiveness can be limited by insensitivity some patients, profoundly impacting their quality life. Through preliminary research, it found that TREM2 + macrophages play pivotal role non‐responsiveness to immunotherapy. To address this challenge, novel ionizing radiation‐responsive delivery system developed for precise expression anti‐TREM2 single‐chain antibody fragments (scFv) using an engineered probiotic, Escherichia coli Nissle 1917 (EcN), modulate The released scFv precisely targeted and delivered tumor site via EcN outer membrane vesicles (OMVs), thereby reversing immunosuppressive microenvironment enhancing therapeutic efficiency when used combination with αPD‐L1 immune checkpoint inhibitor. Additionally, these bacteria further modified enhance intestinal colonization capabilities through oral administration, regulating gut microbiota metabolic byproducts. Consequently, drug based on not only introduces promising new option cancer but also showcases potential finely tune responses within intricate microenvironment, paving way innovative strategies radio‐immunotherapy.

Language: Английский

Citations

2
Chimeric Antigen Receptor Cells Solid Tumor Immunotherapy Assisted by Biomaterials Tools DOI
Yujun Song, Yifan Wang,

Jianping Man

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Chimeric antigen receptor (CAR) immune cell therapies have revolutionized oncology, particularly in hematological malignancies, yet their efficacy against solid tumors remains limited due to challenges such as dense stromal barriers and immunosuppressive microenvironments. With advancements nanobiotechnology, researchers developed various strategies methods enhance the CAR tumor treatment. In this Review, we first outline structure mechanism of CAR-T (T, T cell), CAR-NK (NK, natural killer), CAR-M (M, macrophage) deeply analyze potential these cells treatment they face. Next, explore how biomaterials can optimize treatments by improving microenvironment, controlling release, promoting infiltration, enhancing efficacy. Finally, summarize current solutions, emphasize effective combination therapy, look forward its future clinical application strategies. This Review provides important theoretical perspectives practical guidance for development more

Language: Английский

Citations

0
Bacterial extracellular vesicles for gut microbiome-host communication and drug development DOI Creative Commons

Dingfei Qian,

Panpan Xu, Xinwei Wang

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Citations

0
Nanoarchitecting intelligently encapsulated designs for improved cancer therapy DOI Creative Commons

Ying‐Tong Ye,

Hong‐Ying Xia,

Jie Li

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: May 1, 2025

Despite the success in exploring various aspects of origination and therapeutic strategies, cancer has remained one most dreadful metabolic disorders due to failure eradicate tumors comprehensively frequent recurrence because acquired resistance drugs. Recently, several advancements have been evidenced fabrication smart nanocarriers encapsulated with multiple components. Several reasons for nanoencapsulation include enhancement bioavailability drugs, precise targetability reduce adverse effects on normal cells, ability enable controlled drug release rates at tumor sites. In addition, these protect cargo from deactivation, responsively delivering it based physiological or pathological characteristics tumors. this review, we present approaches therapy, including organic materials, inorganic components, their composites, as well biomembrane-based strategies. These along practical applications potential treatment, are discussed depth, highlighting advantages disadvantages, aiming reveal ultimate prospects enhancing delivery efficiency targeted therapy.

Language: Английский

Citations

0
Engineering Escherichia coli Nissle 1917 Carrying PD1 Agonists Resolves Intestinal Inflammation via Local Immune Modulation DOI
Meng‐Yuan Hu, Tingting Li, Mengmeng Xu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: May 9, 2025

Immunological imbalance is a key factor in the progression of intestinal inflammation, yet effective treatments remain elusive. Using radiation-induced injury model, we investigated causes inflammation at single-cell level and identified abnormal T-cell activation as major contributor. To address this, targeted PD1 signaling pathway to suppress evaluated anti-inflammatory repair effects agonist displaying probiotic Escherichia coli Nissle 1917 (EcNMP1-M) two mouse models. Encapsulated Eudragit L100-55 for pH-dependent release, EcNMP1-M its bacterial outer membrane vesicles (OMVs) expressed agonists, which inhibited excessive immune reduced inflammatory cytokines. promoted expression proteins that maintain epithelial barrier integrity, improving gut function responses colitis mice. Furthermore, 16S rDNA microbiome sequencing revealed enhanced microbiota diversity, increased beneficial bacteria, harmful bacteria. This study proposes localized EcN-based immunosuppressive therapy enteritis bowel disease with promising potential clinical applications.

Language: Английский

Citations

0
Bioinspired micro‐ and nanostructured systems for cancer therapy DOI Creative Commons
Ruizhen Yang, Bing Zhang,

Xiawei Fei

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(12)

Published: Nov. 28, 2024

Abstract Numerous organisms in nature have demonstrated enhanced biocompatibility, precise tumor targeting capabilities, and efficient tissue traversal within the human body. Drawing inspiration from these organisms, researchers employed bioengineering, bioconjugation, micro‐ or nanotechnology to fabricate bioinspired nanostructured systems. These systems play a crucial role addressing limitations of conventional anticancer drugs nanomaterials concerning effective penetration physiological barriers, as well selective targeting, thereby leading improved therapeutic efficacy while minimizing nonspecific adverse effects on healthy cells. Consequently, extensive exploration has been undertaken across various cancer treatment modalities with some progressing into preclinical clinical stages. However, our understanding this field remains limited which may impede research progress, translation efforts, practical applications. Therefore, study presents systematic classification for therapy that comprehensively elucidates their sources design principles. Furthermore, it extensively discusses current status efforts identifying prevailing challenges exploring future prospects. This work will establish robust theoretical framework serve valuable reference facilitate advancements application field.

Language: Английский

Citations

1