Harnessing Ultrasonic Technologies to Treat Staphylococcus Aureus Skin Infections DOI Creative Commons
John Hulme

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 512 - 512

Published: Jan. 23, 2025

The rise of antibiotic-resistant Staphylococcus aureus strains, particularly MRSA, complicates the management skin and soft tissue infections. This review highlights ultrasonic methodologies as adjunctive therapies to combat S. aureus-driven infections prevent progression biofilm formation chronic wounds. Low- high-frequency ultrasound (LFU HFU) demonstrate potential in disrupting biofilms, enhancing drug delivery, promoting repair through cavitation microbubble activity. These approaches integrate frequencies with microbubbles therapeutics, such antibiotics affimers, minimize resistance improve healing. Tailoring bioeffects on structures localized delivery technologies, including microneedle patches piezoelectric systems, presents promising solutions for early intervention structure (SSSIs).

Language: Английский

Research Progress and Prospects of Liquid–Liquid Triboelectric Nanogenerators: Mechanisms, Applications, and Future Challenges DOI
Yuanyuan Pan,

Jilong Song,

Kai Wang

et al.

ACS Applied Electronic Materials, Journal Year: 2024, Volume and Issue: 7(1), P. 1 - 12

Published: Dec. 23, 2024

The liquid–liquid triboelectric nanogenerator (L-L TENG) is an emerging nanogeneration technology that converts weak mechanical energy, tidal and other forms of energy into electricity through the frictional interactions between liquids. This paper reviews research progress L-L TENG. First, it provides overview working principles TENG, analyzes its basic mechanisms, summarizes fundamental operation modes while organizing materials currently used for charge transfer. Additionally, this outlines applications TENG in harvesting, medicine, fields, offering insights performance enhancement expansion application scenarios. Finally, discusses challenges facing development as well future direction potential applications. Overall, conversion technology, has attracted widespread interest from scientists worldwide. review aims to provide scientists, engineers, researchers related fields with a comprehensive perspective further advance area research.

Language: Английский

Citations

26

Wireless Thermoelectric Hydrogel Recreates Biomimetic Electric Field and Angiogenic Signal Accelerating Diabetic Ulcer Repair DOI

Minhong Tan,

Yuda Liu, Yiyi Wang

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Abstract Endogenous electric field (EF)‐actuated reepithelization, dermal formation, and growth factors‐induced angiogenesis are crucial for wound healing. It is however, challenging to initiate both endogenous EF factors in diabetic ulcer due severe electrolyte loss hyperglycemia‐resulted endothelial dysfunction. Current therapeutic systems supply electrostimulation by integrating self‐powered conductive materials continue encounter obstacles nondegradability‐induced low biocompatibility anisotropic EF‐resulted limited regeneration. Recombinant also high cost, stability, potential bio‐risk. Herein, a wireless biocompatible thermoelectric hydrogel (HFN) co‐crosslinked biodegradable hyaluronic acid polyether F127 developed achieve effective directional‐EF stimulation. Target‐modified ginseng‐derived exosomes (RGE) further embedded the design of HFN‐RGE enhanced Specifically, recreates biomimetic through “cationic trap” effect trigger robust epithelial fibroblast electrotaxis, meanwhile controlling release precise pro‐angiogenic with unique ability reverse In vivo, demonstrated stimulate reepithelialization, regeneration, nascent vessel network reconstruction. Single‐cell RNA‐seq revealed that activates PPAR signaling‐meditated tissue As such this work provides promising electrical‐biological hybrid system biosafety therapy.

Language: Английский

Citations

1

Harnessing Ultrasonic Technologies to Treat Staphylococcus Aureus Skin Infections DOI Creative Commons
John Hulme

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 512 - 512

Published: Jan. 23, 2025

The rise of antibiotic-resistant Staphylococcus aureus strains, particularly MRSA, complicates the management skin and soft tissue infections. This review highlights ultrasonic methodologies as adjunctive therapies to combat S. aureus-driven infections prevent progression biofilm formation chronic wounds. Low- high-frequency ultrasound (LFU HFU) demonstrate potential in disrupting biofilms, enhancing drug delivery, promoting repair through cavitation microbubble activity. These approaches integrate frequencies with microbubbles therapeutics, such antibiotics affimers, minimize resistance improve healing. Tailoring bioeffects on structures localized delivery technologies, including microneedle patches piezoelectric systems, presents promising solutions for early intervention structure (SSSIs).

Language: Английский

Citations

0