Rational formulation of saponin and dexamethasone for the synergistic treatment of rheumatoid arthritis in vivo DOI

Yaru Yue,

Zhengquan Liao,

Yingqian Zhou

et al.

Applied Materials Today, Journal Year: 2024, Volume and Issue: 40, P. 102381 - 102381

Published: Aug. 20, 2024

Language: Английский

Recent Progress in Microenvironment‐Responsive Nanodrug Delivery Systems for the Targeted Treatment of Rheumatoid Arthritis DOI
Shuhang Liu, Ming Yang, Han Liu

et al.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(6)

Published: Nov. 1, 2024

ABSTRACT Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that often causes joint pain, swelling, and functional impairments. Drug therapy the main strategy used to alleviate symptoms of RA; however, drug may have several adverse effects, such as nausea, vomiting, abdominal diarrhea, gastric ulcers, intestinal bleeding, hypertension, hyperglycemia, infection, fatigue, indigestion. Moreover, long‐term excessive use drugs cause liver kidney dysfunction, well thrombocytopenia. Nanodrug delivery systems (NDDSs) can deliver therapeutics diseased sites with controlled release payload in an abnormal microenvironment, which helps reduce side effects therapeutics. Abnormalities decreased pH, increased expression matrix metalloproteinases (MMPs), concentrations reactive oxygen species (ROS), are associated progression RA but also provide opportunity achieve microenvironment‐responsive therapeutic at site. Microenvironment‐responsive NDDSs overcome abovementioned disadvantages therapy. Herein, we comprehensively review recent progress development for treatment, including pH‐, ROS‐, MMP‐, multiresponsive NDDSs. Furthermore, pathological microenvironment highlighted detail.

Language: Английский

Citations

2
A nanoprodrug derived from branched poly (ethylene glycol) recognizes prostate-specific membrane antigen to precisely suppress prostate cancer progression DOI
Shiwei Guo, Yu Cao, Bowen Cheng

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 136831 - 136831

Published: Oct. 23, 2024

Language: Английский

Citations

1
Rational formulation of saponin and dexamethasone for the synergistic treatment of rheumatoid arthritis in vivo DOI

Yaru Yue,

Zhengquan Liao,

Yingqian Zhou

et al.

Applied Materials Today, Journal Year: 2024, Volume and Issue: 40, P. 102381 - 102381

Published: Aug. 20, 2024

Language: Английский

Citations

0