Applications of advances in therapeutic electrical stimulation techniques and technologies in precision peripheral nerve repair: a narrative review

Advanced technology in neuroscience ., Journal Year: 2025, Volume and Issue: 2(2), P. 97 - 101

Published: April 8, 2025

Peripheral nerve injuries affect large numbers of individuals each year, often resulting in long-term disabilities due to impairments motor and sensory function. With traditional treatment approaches, including surgical repair rehabilitation, the most common outcome is incomplete recovery. This compounded by absence FDA-approved medications enhance regeneration. Recent advances therapeutic electrical stimulation techniques have shown promise improve axonal regrowth functional Typically administered perioperatively a single 1-hour session, has demonstrated efficacy both preclinical studies small clinical trials promoting faster more complete To address limitations stimulation, infection risks or lead displacement, recent development bioresorbable stimulator implants introduced groundbreaking solution. Furthermore, patient-specific factors, age, sex, medical comorbidities, genetic variability, notably interact with outcomes potential responsiveness stimulation. Such genes include prevalent Val66Met polymorphism brain-derived neurotrophic factor gene (rs6265). Carriers rs6265 less regeneration, impaired activity-dependent secretion, diminished response studies. highlights growing importance tailoring protocols patient for optimal outcomes. The future peripheral injury will involve integration sophisticated stimulators deliver tailored protocols, careful consideration given factors personalized rehabilitation strategies maximize

Language: Английский

Recent approaches in the application of antimicrobial peptides in food preservation

World Journal of Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 40(10)

Published: Sept. 9, 2024

Language: Английский