Polyphenol‐Regulated Bimetallic Artificial Metalloproteinases with Broad‐Spectrum RONS Scavenging Activities for Diabetic Wound Repair

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Abstract Although numerous enzyme‐mimicking nanomaterials have been developed to regulate the highly reactive oxygen species (ROS)‐rich microenvironment of diabetic wounds for improving its healing, poor broad‐spectrum ROS‐scavenging capacity and biological toxicity resulting from side reactions still require improvement. To tackle these challenges, a polyphenol‐mediated copper‐bismuth bimetallic artificial metalloproteinases, CuBi‐TA@BSA, based on protein‐scaffold design strategy, is conceptually engineered. The Bi polyphenols can cooperatively enhance loading Cu ions their coordination within BSA scaffold. CuBi‐TA@BSA exhibits remarkable scavenging activity against various ROS via effectively donating electrons, as well reaction pathway specificity catalytic H 2 O decomposition without POD‐like activity. Moreover, in vitro vivo studies further confirm that protect cells oxidative damage, inhibit onset progression inflammation, promote wound healing. This work presents simple strategy biocatalysts scavenge accelerate wound‐healing process, also provides designing metalloproteinases antioxidative therapy.

Language: Английский

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Near-Infrared Light-Controlled Nitric Oxide Delivery Combined with In Situ Activated Chemotherapy for Enhanced Multimodal Therapy

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Development of nanoplatforms with in situ activation for chemotherapy represents a promising modality biomedical application. Herein, multifunctional nanoplatform, CMS@DTC@PDA@RuNO@FA (abbreviated as CDPNF NPs), was developed highly efficient antitumor therapy, which diethyldithiocarbamate (DTC)-loaded mesoporous Cu2MoS4 (CMS) nanoparticles were covered by polydopamine (PDA) layers and further covalently modified NO donor (RuNO) folic acid (FA)-directing moiety. Under the mild acidic tumor microenvironment (TME), NPs co-liberated DTC Cu2+ site, where formation cytotoxic Cu(DTC)2 complex effectively killed cells. Furthermore, under near-infrared (NIR) light irradiation, could deliver nitric oxide (NO) produce superoxide anions (O2•-), followed more toxic peroxynitrite (ONOO-), led to promoted cell apoptosis. 1064 nm NIR vivo experiments demonstrated an impressively high inhibition rate (∼97%) while good biocompatibility. This work activated approach precision medicine that might imply its potential clinical applications.

Language: Английский

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Recent research progress on metal ions and metal-based nanomaterials in tumor therapy

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 7, 2025

Tumors, as a disease that seriously threatens human health, have always been major challenge in the field of medicine. Currently, main methods tumor treatment include surgery, radiotherapy, chemotherapy, etc., but these traditional often certain limitations. In addition, recurrence and metastasis are also difficult problems faced clinical treatment. this context, importance metal-based nanomaterials therapy is increasingly highlighted. Metal-based possess unique physical, chemical, biological properties, providing new ideas for can achieve targeted tumors through various mechanisms, reducing damage to normal tissues; they serve drug carriers, improving stability bioavailability drugs; at same time, some photothermal, photodynamic, other characteristics, which be used phototherapy tumors. This review examines latest advances application within past 5 years, presents prospective insights into future applications.

Language: Английский

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Dual-purposing disulfiram for enhanced chemotherapy and afterglow imaging using chlorin e6 and semiconducting polymer combined strategy

Theranostics, Journal Year: 2024, Volume and Issue: 14(13), P. 5141 - 5151

Published: Jan. 1, 2024

One of the main challenges in chemotherapy is achieving high treatment efficacy while minimizing adverse events. Fully exploiting therapeutic potential an old drug and monitoring its effects

Language: Английский

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Cuproptosis: an emerging domain for copper-based nanomaterials mediated cancer therapy

MedMat., Journal Year: 2024, Volume and Issue: 1(2), P. 74 - 94

Published: Dec. 1, 2024

Cuproptosis, a newly discovered copper-dependent mode of cell death, has received extensive attention in the field cancer therapy due to its specific activation pathway. Rapid accumulation large amounts copper ions within cells achieve overload is key activating cuproptosis. Advanced nanotechnology offers considerable promise for delivering cells, which copper-based nanomaterials have been proposed evoke cuproptosis-mediated therapy. However, it still great challenge induce specifically tumors and efficiently activate subsequent cuproptosis-related molecular pathways. Therefore, necessary summarize strategies used effectively or amplify cuproptosis based on currently developed nanomaterials, providing ideas design future. In this review, that can be are systematically classified selection. Subsequently, sensitization using provided therapeutic efficiency. Meanwhile, combination therapies maximizing treatment efficacy delineated. Ultimately, remaining challenges feasible future directions use tumor also discussed.

Language: Английский

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