Dimerized Pentamethine Cyanines for Synergistically Boosting Photodynamic/Photothermal Therapy

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

ABSTRACT Photodynamic therapy (PDT) and photothermal (PTT) have emerged promising applications in both fundamental research clinical trials. However, it remains challenging to develop ideal photosensitizers (PSs) that concurrently integrate high photostability, large near‐infrared absorptivity, efficient therapeutic capabilities. Herein, we reported a sample engineering strategy afford benzene‐fused Cy5 dimer ( Cy‐D‐5 ) for synergistically boosting PDT/PTT applications. Intriguingly, exhibits tendency form J ‐aggregates H phosphate‐buffered saline, which show long‐wavelength absorption band bathochromically shifted 810 nm short‐wavelength hypsochromically 745 nm, respectively, when compared its behavior ethanol (778 nm). Density‐functional theory calculations combined with time‐resolved transient optical spectroscopy analysis reveal the fused low Δ E ST (0.51 eV) non‐radiative transition rates (12.6 times greater than of clinically approved PS‐indocyanine green [PS‐ ICG ]). Furthermore, demonstrates higher photosensitizing ability produce 1 O 2 , stronger conversion efficiency η = 64.4%), photostability . These properties enable achieve complete tumor ablation upon 808 laser irradiation, highlighting potential as powerful dual‐function phototherapeutic agent. This work may offer practical other existing dyes red‐shifted spectral range various phototherapy

Language: Английский

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Recent advances in nanomaterials for integrated phototherapy and immunotherapy

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 535, P. 216608 - 216608

Published: March 27, 2025

Language: Английский

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New NIR‐Activated Organic Molecule‐Based Nanocomposite as an Efficient Sensitizer for Photothermal and Photodynamic Therapy of Cancer

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Acceptor-donor-acceptor (A-D-A)-configured molecules with coplanar dithieno[2,3-d:2',3'-d']thieno[3,2-b:3',2'-b']dipyrrole (DTPT) as the core are promising organic semiconductor materials utilized in photovoltaic devices owing to their efficient charge transportation capabilities. In addition optoelectronic applications, they potential photothermal and photodynamic applications due light-absorption properties. This study evaluates utilization of DTPT-based fused-ring-conjugated small strong near-infrared (NIR) absorption stable photosensitizers for phototherapy by forming nanoparticles (NPs) D-α-tocopherol polyethylene glycol 1000 succinate (TPGS). Among them, NPs prepared from 2-(3-cyano-4,5,5-trimethylfuran-2(5H)-ylidene)malononitrile (TCF) end-capping DTPT-centered molecule, DTPTTCF, exhibit low cytotoxicity, enhance conversion efficiency superior activity. vitro vivo experiments demonstrate remarkable anticancer efficacy DTPTTCF@TPGS that can effectively suppress cancer cell proliferation under 808 nm laser treatment. Additionally, soft X-ray tomography (SXT) is employed a high-resolution tool observe intracellular variations reveal distinct vacuolization + Laser treated group. These observations highlight cause significant damage cells NIR irradiation. Furthermore, vivo, apoptosis within tumor tissues effective elimination tumors upon irradiation mice. work manifests application DTPT-cored A-D-A-type molecule an advanced agent enhanced selectivity.

Language: Английский

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Disruption of Ferroptosis Inhibition and Immune Evasion with Tumor‐Activatable Prodrug for Boosted Photodynamic/Chemotherapy Eradication of Drug‐Resistant Tumors

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Breast cancer is a malignant tumor that threatens the life and health of women worldwide. As first-line chemotherapy drug for breast cancer, doxorubicin (DOX) can inhibit synthesis RNA DNA, it exhibits strong inhibitory activity against cancer. However, drug-induced systemic toxicity resistance occur with DOX treatment. In this work, TSPO protein identified as promising target overcoming we designed novel BT-DOX/PDP conjugate to solve these problems in chemotherapy. It found effectively downregulate TSPO1 sensitize MCF-7/Adr DOX. Furthermore, due its positive charge, readily loaded into puerarin (PUE), resulting BT-DOX/PDP@PUE exhibited minimal but enhanced antitumor animal models, compared BT-DOX/PDP. This study demonstrates advantages combined photodynamic therapy resistance, which may be applied design other therapy-based conjugates enhance therapy.

Language: Английский

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