Multidimensional exploration of hydrogels as biological scaffolds for spinal cord regeneration: mechanisms and future perspectives DOI Creative Commons
Cheng Han, Jiao Jiao, Chan Gong

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: April 23, 2025

Spinal cord injury (SCI) is a severe condition that frequently leads to permanent disabilities and neurological dysfunction. Its progression driven by multifaceted pathophysiology, encompassing direct trauma, secondary cascades, intricate cellular molecular responses. While current therapies focus on alleviating symptoms restoring functionality, achieving effective neural regeneration in the spinal continues be significant challenge. Hydrogels, recognized for their exceptional biocompatibility, conductivity, injectability, have shown great potential as advanced scaffolds support neuronal axonal regeneration. Recently, these materials attracted interest field of SCI rehabilitation research. This review concludes recent progress hydrogel-based strategies rehabilitation, emphasizing distinct properties, underlying mechanisms, integration with bioactive molecules, stem cells, complementary biomaterials. Hydrogels foster providing tailored microenvironment, while features such self-repair, electrical controlled drug release significantly enhance therapeutic experimental models. explores hydrogel technologies applications, underscoring address challenges treatment paving way future clinical implementation.

Language: Английский

From Microsphere Synthesis to Neural Tissue Regeneration: Unraveling the Potentials and Progress DOI
Yaqiong Liu,

Yuqing Shang,

Zhen Wang

et al.

Composites Part B Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 112363 - 112363

Published: March 1, 2025

Language: Английский

Citations

0
Bioactive Peptide-MOF based nanogel for peripheral nerve repair through remodeling the regenerative microenvironment DOI
Yifan Wu, Longwei Hu, Xu Zhang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161831 - 161831

Published: March 1, 2025

Language: Английский

Citations

0
Specific activation of cGAS-STING pathway by manganese-doped bioactive glasses for boosting systemic tumor immunotherapy DOI Creative Commons
Zhaolin Yang, Jiale Zhou, Xinrui Wu

et al.

Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113764 - 113764

Published: Feb. 1, 2025

Language: Английский

Citations

0
Multidimensional exploration of hydrogels as biological scaffolds for spinal cord regeneration: mechanisms and future perspectives DOI Creative Commons
Cheng Han, Jiao Jiao, Chan Gong

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: April 23, 2025

Spinal cord injury (SCI) is a severe condition that frequently leads to permanent disabilities and neurological dysfunction. Its progression driven by multifaceted pathophysiology, encompassing direct trauma, secondary cascades, intricate cellular molecular responses. While current therapies focus on alleviating symptoms restoring functionality, achieving effective neural regeneration in the spinal continues be significant challenge. Hydrogels, recognized for their exceptional biocompatibility, conductivity, injectability, have shown great potential as advanced scaffolds support neuronal axonal regeneration. Recently, these materials attracted interest field of SCI rehabilitation research. This review concludes recent progress hydrogel-based strategies rehabilitation, emphasizing distinct properties, underlying mechanisms, integration with bioactive molecules, stem cells, complementary biomaterials. Hydrogels foster providing tailored microenvironment, while features such self-repair, electrical controlled drug release significantly enhance therapeutic experimental models. explores hydrogel technologies applications, underscoring address challenges treatment paving way future clinical implementation.

Language: Английский

Citations

0