A Smart MMP‐9‐responsive Hydrogel Releasing M2 Macrophage‐derived Exosomes for Diabetic Wound Healing

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 16, 2025

Chronic diabetic wounds are characterized by prolonged inflammation and excessive accumulation of M1 macrophages, which impede the healing process. Therefore, resolving promptly transitioning to proliferative phase critical steps for effective wound healing. Exosomes have emerged as a promising therapeutic strategy. In this study, smart hydrogel capable responding pathological cues in inflammatory microenvironment promote transition from proliferation delivering M2 macrophage-derived exosomes (M2-Exos) is developed. The synthesized through cross-linking oxidized dextran, matrix metalloproteinase (MMP)-9-sensitive peptide, carboxymethyl chitosan containing M2-Exos. response elevated MMP-9 concentrations microenvironment, demonstrates diagnostic logic, adjusting release kinetics M2-Exos accordingly. on-demand facilitated macrophage polarization phenotype, thereby promoting accelerating transcriptomic analysis further reveals that MMP-9-responsive with delivery exerts anti-inflammatory regenerative effects downregulating inflammation-related pathways. This study introduces an innovative, microenvironment-responsive exosome system enables precise control agent release, offering personalized approach treatment chronic wounds.

Language: Английский

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Nanoparticle-Reinforced Hydrogel with a Well-Defined Pore Structure for Sustainable Drug Release and Effective Wound Healing

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Impaired chronic wounds are a common complication of diabetes. Inhibited angiogenesis and dysfunctional inflammation render diabetic wound healing critical challenge. Herein, sustainable therapeutic composite hydrogel is presented for healing, consisting cocktail formulation anti-inflammatory local anesthetic nanoparticles incorporated into hydrogel. The surface-modified drug loaded the biocompatible hydrogels cross-linked with gel precursor to enhance structure. delivery system achieves more than 90% release, total therapy duration tunable from 4 72 h. Through long-lasting analgesic effects hydrogel, swiftly transitioned proliferation phase, augmenting survival migration keratinocytes facilitating neovascularization collagen alignment in wounds. These significantly improve rate skin regeneration process, achieving that 17 times untreated This study demonstrates platform promising rapid

Language: Английский

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A review on recent progress in polysaccharide/protein hydrogels in winter sports: Classification, synthesis routes, and application

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140732 - 140732

Published: Feb. 1, 2025

Language: Английский

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Sustained release of migrasomes from a methacrylate-oxidized hyaluronic acid/methacrylated gelatin composite hydrogel accelerates skin wound healing

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141355 - 141355

Published: Feb. 1, 2025

Language: Английский

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Dual Enzyme-Mimic Popcorn-Shaped Copper–Erbium Nanoalloys for Combating Gram-Negative Pathogens and Promoting Wound Healing

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Language: Английский

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Exosomes-based Therapeutics in Dermatology

Biomaterials Research, Journal Year: 2025, Volume and Issue: 29

Published: Jan. 1, 2025

Exosomes (Exos) are tiny extracellular vesicles containing a variety of active biomolecules that play important parts in intercellular communication and influence the functions target cells. The potential Exos treatment dermatological diseases has recently been well appreciated. This review highlights constituents, function, delivery Exos, with particular focus on their applications skin therapy. Firstly, we offer concise overview biochemical properties including sources, structures, internal constituents. Subsequently, biomedical latest advances extraction purification summarized. We further discuss modes underscore biomaterials this regard. Finally, summarize application Exo-aided therapy dermatology. Overall, objective is to provide comprehensive perspective recent advancements Exo-based approaches treating diseases, intention guiding future research efforts.

Language: Английский

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Mussel-Inspired Hydrogel Applied to Wound Healing: A Review and Future Prospects

Biomimetics, Journal Year: 2025, Volume and Issue: 10(4), P. 206 - 206

Published: March 26, 2025

The application background of mussel-inspired materials is based on the unique underwater adhesive ability marine mussels, which has inspired researchers to develop bionic with strong adhesion, self-healing ability, biocompatibility, and environmental friendliness. Specifically, 3, 4-dihydroxyphenylalanine (DOPA) in mussel byssus able form non-covalent forces a variety surfaces, are critical for mussel's adhesion enable material dissipate energy repair itself under external forces. Mussel-inspired hydrogels ideal medical due their physical chemical properties, such as excellent tissue hemostasis bacteriostasis, biosafety, plasticity. This paper reviewed chitosan, cellulose, hyaluronic acid, gelatin, alginate, other biomedical discussed advanced functions wound dressings, including antibacterial, anti-inflammatory, antioxidant hemostasis, transport, self-healing, stimulating response, so on. At same time, technical challenges limitations biomimetic hydrogel applications were further discussed, its potential solutions future research developments field biomedicine highlighted.

Language: Английский

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Cascade Nanozyme-Loaded Sprayable Hydrogels for Fibroblast Rejuvenation and Diabetic Wound Regeneration

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 29, 2025

Multifunctional composite wound dressings hold significant promise for diabetic healing. However, the detrimental role of advanced glycation end-products (AGEs)-reactive oxygen species (ROS) cycle in impeding repair remains underexplored. To disrupt this pathological cycle, zeolitic imidazolate framework-8 (ZIF-8) encapsulated cerium dioxide (CeO2) and adsorbed glucose oxidase (GOx) nanozyme particles ((ZIF-8@CeO2)@GOx, zcg) were loaded into a methacrylic anhydride-modified gelatin (GelMA) hydrogel to form sprayable dressing, zcg/GelMA (zcgG). Physicochemical characterization revealed that GOx catalyzes oxidation, triggering ZIF-8 acid-mediated decomposition release zinc ions CeO2 nanoparticles, thereby enabling cascade depletion, antioxidant, antiglycation functions. In vitro antimicrobial cytotoxicity experiments optimized zcg concentration GelMA. Under oxidative hyperglycemic culture conditions, we validated mechanism blocking AGEs-ROS restoring fibroblast mitochondrial membrane potential, subsequently suppressing cellular senescence. bacterial-infected rat skin model, zcgG group demonstrated substantially reduced inflammatory levels, 68% decrease AGEs, 1.9-fold increase collagen deposition compared blank controls. Within 2 weeks, achieved complete closure, while control retained 28% initial area. This work provides preliminary evidence feasibility using nanozymes break promote

Language: Английский

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A gelatin microneedles featuring antibacterial and reactive oxygen species scavenging properties for treating Vibrio vulnificus-infected wounds

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142640 - 142640

Published: March 1, 2025

Language: Английский

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Metal ion crosslinked polysaccharide hydrogels: A review on their potential for therapeutic delivery and tissue engineering

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 310, P. 143467 - 143467

Published: April 23, 2025

Language: Английский

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