International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 144352 - 144352
Published: May 1, 2025
Language: Английский
World Journal of Diabetes, Journal Year: 2025, Volume and Issue: 16(5)
Published: April 24, 2025
Diabetic wounds represent a significant challenge in the medical field, significantly impacting patient quality of life and imposing heavy burden on healthcare systems. Intelligent hydrogel dressings have attracted attention diabetic wound treatment due to their unique properties. This review systematically explores three main categories intelligent hydrogels (natural, synthetic, composite), dissecting composition, structure, mechanisms that enable responses. The crucial roles these maintaining moist environment, efficiently absorbing exudate, precisely delivering drugs are expounded. Moreover, application advantages combating bacteria infections, regulating inflammation immunity, promoting angiogenesis tissue regeneration, as well enabling real-time monitoring personalized treatment, explored depth. Additionally, we discuss future research directions prospects for precision medicine care, aiming inspire innovation provide comprehensive theoretical basis development next-generation dressings.
Language: Английский
Citations
0
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 677, P. 125668 - 125668
Published: May 1, 2025
Antimicrobial peptides (AMPs) such as LL37 offer a promising alternative to conventional antibiotics in treating chronic and multidrug-resistant wound infections. However, their clinical translation is limited by rapid degradation cytotoxicity at high concentrations. This study investigates the encapsulation of palmitoylated FDA-approved poly(lactic-co-glycolic acid) (PLGA) nanoparticles using two fabrication techniques, nanoprecipitation microfluidics, enhance stability controlled peptide release. Microfluidic-generated demonstrated superior size uniformity, smaller hydrodynamic (102.3 ± 2.0 nm vs 189.3 3.4 nm), improved stability, prolonged LL37(P) release compared obtained via bulk method. LL37-encapsulated release, enhanced keratinocyte uptake, significant fibroblast-mediated closure acceleration. Proteomic analysis nanoparticle-protein corona revealed enrichment proteins involved coagulation, inflammation modulation, extracellular matrix remodelling, suggesting an active role modulating healing microenvironment. These findings highlight PLGA-based loaded nanocarriers biopolymer platform for AMP delivery applications viable therapeutic strategy regenerative medicine infection control.
Language: Английский
Citations
0
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: May 6, 2025
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: May 15, 2025
Oral ulcer is a common oral mucosal injury disease that causes significant inconvenience and discomfort for patients. Traditional treatments, such as drugs, ointments, patches, have limitations, including low local drug utilization, short residence time on the affected area, risk of secondary from manual application. To address these issues, this study developed sprayable temperature-sensitive hydrogel (PEI/PAA/PF127-CHO/AA2G@MSN-NH2 hydrogel, PMAG) without contact injuryed mucosa by combining aldehyde-modified Pluronic F-127 (PF127-CHO), ascorbic acid 2-glucoside-loaded amino-mesoporous silica (AA2G@MSN-NH2), polyethylenimine (PEI), polyacrylic (PAA) through Schiff base reaction physical crosslinking. When sprayed onto an ulcer, PMAG exhibits excellent temperature sensitivity adhesion, rapidly adapting to forming protective film closely adheres surface. This creates stable healing environment isolating wound external stimuli. has demonstrated abilities in promoting epithelial cell proliferation migration, well antioxidant, anti-inflammatory, antibacterial properties. RNA sequencing revealed tissue repair-promoting effects are primarily mediated activating nerve growth factor receptor/extracellular signal-regulated kinase (NGFR/ERK) signaling pathway. In summary, represents advancement improving treatment ulcers offers more convenient option
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 144352 - 144352
Published: May 1, 2025
Language: Английский
Citations
0