Recent advances of anti-tumor nano-strategies via overturning pH gradient: alkalization and acidification

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 24, 2025

The acidic tumor microenvironment, a hallmark of many solid tumors, is primarily induced by the high glycolytic rate cells. To avoid acidosis, cells ingeniously maintain an extracellular pH while keeping relatively alkaline intracellular pH. Overturning unique gradient has exhibited to be viable approach for cancer therapy. In this review, formation and regulatory mechanisms microenvironment in tumors will firstly outlined. Subsequently, we comprehensively summarize latest advancements anti-tumor therapy via using nanomedicines manipulate gradient, including acidifying environment alkalizing environment. Following this, discuss future potential strategies employing reverse gradient. This review aims foster research on therapeutic approaches targeting regulation holds optimistic outlook development field.

Language: Английский

Metal-organic coordinated self-assembled nanomedicine for enhanced cuproptosis-mediated chemo-photo-chemodynamic synergistic therapy of non-small cell lung cancer

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161305 - 161305

Published: March 1, 2025

Language: Английский