Encapsulation of Monoterpene Phenols in Protein-Stabilized Nanoemulsions for Improved Wound Healing DOI
Mengran Wang, Xue Ma, Xinxin Han

et al.

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: March 23, 2025

Monoterpene phenols have antibacterial, antioxidant, anticancer, antihypertensive, and antidiabetic properties, but their natural volatility hydrophobicity limit biomedical applications. In this work, we developed an oil-in-water nanoemulsion (NE) stabilized by proteins (i.e., sodium caseinate, NaCas) polyphenols tannic acid, TA) using phacoemulsification, where thymol (TH) was dissolved in carvacrol (CA) the mixture used as dispersed phase. The NE avoids use of traditional surfactants stabilizer. Amphiphilic NaCas could stabilize NE, followed further cross-linking TA. These antimicrobial agents monoterpene were efficiently encapsulated to enhance colloidal stability aqueous solution. resulting showed strong antibacterial activity, reduced inflammation ability, improved healing bacteria-infected wounds. TA acted both stabilizer a synergistic agent boost effects accelerate wound repair. This work demonstrates promising strategy for delivering treat infected

Language: Английский

Encapsulation of Monoterpene Phenols in Protein-Stabilized Nanoemulsions for Improved Wound Healing DOI
Mengran Wang, Xue Ma, Xinxin Han

et al.

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: March 23, 2025

Monoterpene phenols have antibacterial, antioxidant, anticancer, antihypertensive, and antidiabetic properties, but their natural volatility hydrophobicity limit biomedical applications. In this work, we developed an oil-in-water nanoemulsion (NE) stabilized by proteins (i.e., sodium caseinate, NaCas) polyphenols tannic acid, TA) using phacoemulsification, where thymol (TH) was dissolved in carvacrol (CA) the mixture used as dispersed phase. The NE avoids use of traditional surfactants stabilizer. Amphiphilic NaCas could stabilize NE, followed further cross-linking TA. These antimicrobial agents monoterpene were efficiently encapsulated to enhance colloidal stability aqueous solution. resulting showed strong antibacterial activity, reduced inflammation ability, improved healing bacteria-infected wounds. TA acted both stabilizer a synergistic agent boost effects accelerate wound repair. This work demonstrates promising strategy for delivering treat infected

Language: Английский

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