Biosilicification-mimicking chiral nanostructures for targeted treatment of inflammatory bowel disease DOI Creative Commons

Miao Xu,

Wei Xin,

Jiabin Xu

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 15, 2025

The cascade reaction of lipopolysaccharides (LPS), cell-free DNA (cfDNA), and reactive oxygen species (ROS), drives the development inflammatory bowel disease (IBD). Herein, we construct polyethylenimide (PEI)-L/D-tartaric acid (L/D-TA) complexes templated mesoporous organosilica nanoparticles (MON) (PEI-L/D-TA@MON) by mimicking biosilicification under ambient conditions within seconds. chiral nanomedicines include four functional moieties, wherein PEI electrostatically attracts cfDNA, tetrathulfide bonds reductively react with ROS, silanol groups adsorb LPS, L/D-TA enables recognition localization. Following oral administration, PEI-L-TA@MON exhibiting preferential conformation stereoscopically matches mucosa anchors onto intestine for lesion targeting. eliminates alleviating oxidative stress, inhibiting cascade, maintaining immune homeostasis to achieve IBD therapy. In addition, rapid synthesis, low cost, energy-free preparation, negligible toxicity, satisfactory therapeutic effect, facile conversion on modes will bring changes treatment, providing research values translational clinical prospects. Here, Xu et. al. composed moieties eliminate cfDNA targeted treatment IBD.

Language: Английский

Advanced biomaterials for targeting mature biofilms in periodontitis therapy DOI
Jie Tao,

Yirong Sun,

Guoliang Wang

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 474 - 492

Published: Feb. 27, 2025

Language: Английский

Citations

0
Recent advances and challenges in metal-based antimicrobial materials: a review of strategies to combat antibiotic resistance DOI Creative Commons
Chuanda Zhu,

Zhenli Diao,

Yuanyuan Yang

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 9, 2025

Despite the availability of a series classical antibiotic drugs, bacterial infections continue to represent significant and urgent threat global human health. The emergence drug-resistant bacteria slow pace development have rendered current treatment methods inadequate in meeting clinical demands infections. Consequently, there is an increasingly vital need for safe, efficient, alternative novel antimicrobial agents medical healthcare field. Over past five years, has been notable expansion field nanomedicine with regard prevention control infectious diseases. objective this article provide comprehensive review latest research developments metal nanomaterials therapy. We begin by delineating gravity infection crisis, subsequently undertaking examination potential mechanisms through which nanoparticles may combat specific applications these diverse In conclusion, we eagerly anticipate future directions believe that continuous technological advancements innovations, will make even more outstanding contributions safeguarding health well-being.

Language: Английский

Citations

0
Biosilicification-mimicking chiral nanostructures for targeted treatment of inflammatory bowel disease DOI Creative Commons

Miao Xu,

Wei Xin,

Jiabin Xu

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 15, 2025

The cascade reaction of lipopolysaccharides (LPS), cell-free DNA (cfDNA), and reactive oxygen species (ROS), drives the development inflammatory bowel disease (IBD). Herein, we construct polyethylenimide (PEI)-L/D-tartaric acid (L/D-TA) complexes templated mesoporous organosilica nanoparticles (MON) (PEI-L/D-TA@MON) by mimicking biosilicification under ambient conditions within seconds. chiral nanomedicines include four functional moieties, wherein PEI electrostatically attracts cfDNA, tetrathulfide bonds reductively react with ROS, silanol groups adsorb LPS, L/D-TA enables recognition localization. Following oral administration, PEI-L-TA@MON exhibiting preferential conformation stereoscopically matches mucosa anchors onto intestine for lesion targeting. eliminates alleviating oxidative stress, inhibiting cascade, maintaining immune homeostasis to achieve IBD therapy. In addition, rapid synthesis, low cost, energy-free preparation, negligible toxicity, satisfactory therapeutic effect, facile conversion on modes will bring changes treatment, providing research values translational clinical prospects. Here, Xu et. al. composed moieties eliminate cfDNA targeted treatment IBD.

Language: Английский

Citations

0