Preparation, characterisation, and testing of reservoir-based implantable devices loaded with tizanidine and lidocaine

Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Abstract Multiple sclerosis is a chronic neuroimmunological disorder that causes progressive disability, primarily in young adults. It places significant burden on healthcare systems due to high medication costs and long-term care needs. Implantable devices offer promising alternative for delivering sustained drug doses the treatment of conditions. This study introduces novel long-acting subcutaneous implant dual-drug delivery: tizanidine (TZ) spasticity management lidocaine (LD) post-insertion pain relief. Reservoir-type implants were developed with TZ core LD shell. Two fabrication methods—direct compression vacuum moulding (VCM)—were evaluated TZ-loaded pellets (3 mm diameter, ~ 10 length) using base hydrochloride. Pellets encapsulated inside biodegradable polycaprolactone (PCL) tubular membrane control release. Direct pellets, made poly(vinyl pyrrolidone) hydroxypropyl-β-cyclodextrin, disintegrated quickly, releasing over 20 days. VCM formulated PCL or PCL/poly(ethylene glycol) (PEG), offered prolonged release: up 200 days 80 Adding PEG accelerated release, reducing duration (TZ base) 125 hydrochloride). was incorporated into membrane, providing three Physicochemical analysis confirmed formulation homogeneity no covalent interactions. These findings highlight potential this system MS-related management, supporting further research improve adherence patient outcomes. Graphical

Language: Английский

Advancements in Wearable and Implantable BioMEMS Devices: Transforming Healthcare Through Technology

Micromachines, Journal Year: 2025, Volume and Issue: 16(5), P. 522 - 522

Published: April 28, 2025

Wearable and implantable BioMEMSs (biomedical microelectromechanical systems) have transformed modern healthcare by enabling continuous, personalized, minimally invasive monitoring, diagnostics, therapy. advanced rapidly, encompassing a diverse range of biosensors, bioelectronic systems, drug delivery platforms, motion tracking technologies. These devices enable non-invasive, real-time monitoring biochemical, electrophysiological, biomechanical signals, offering personalized proactive solutions. In parallel, BioMEMS significantly enhanced long-term targeted delivery, neurostimulation. From continuous glucose intraocular pressure to programmable bioelectric implants for neuromodulation, these are improving precision treatment localized This review explores the materials technologies driving advancements in wearable BioMEMSs, focusing on their impact chronic disease management, cardiology, respiratory care, glaucoma treatment. We also highlight integration with artificial intelligence (AI) Internet Things (IoT), paving way smarter, data-driven Despite potential, face challenges such as regulatory complexities, global standardization, societal determinants. Looking ahead, we explore emerging directions like multifunctional biodegradable power sources, next-generation point-of-care diagnostics. Collectively, position pivotal enablers future patient-centric systems.

Language: Английский

Evaluating the potential of Ultrasound-Assisted Compression for crafting implantable drug delivery systems

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 107056 - 107056

Published: May 1, 2025

Language: Английский