The role of resistance exercise-induced local metabolic stress in mediating systemic health and functional adaptations: could condensed training volume unlock greater benefits beyond time efficiency?
Frontiers in Physiology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 17, 2025
The
majority
of
"specialised"
exercise
configurations
(e.g.,
supersets,
drop
sets,
blood
flow
restriction)
are
being
assessed
as
"shortcuts"
to
hypertrophy
and
strength
improvements.
However,
these
advanced
training
techniques
may
also
offer
significant
benefits
for
systemic
health
functional
outcomes
across
recreational
clinical
populations
via
locally
induced
metabolic
responses.
Stress-regulating
mechanisms
known
enhance
the
body's
resilience
by
facilitating
allostasis,
process
coordinating
adaptive
processes
in
reaction
stressors
such
physical
training.
Yet,
role
local
stress
provoked
resistance
has
not
gained
much
research
attention
despite
its
wide
potential.
Positive
effects
only
linked
improved
muscular
endurance,
primary
secondary
mechanisms,
but
release
myokines,
hormones,
microRNAs,
immune
factors,
inflammatory
substances
other
endocrine
molecules
that
initiate
numerous
health-promoting
modifications
on
a
level.
Resistance
strategies
maximise
accumulation
metabolites
well
defined,
although
high
volume,
close
proximity
failure
shorter
rests
seem
be
necessity.
Additionally,
restriction
provides
potent
alternative
inducing
acidosis,
thereby
triggering
several
pathways
associated
with
immunity
function
even
remote
muscle
tissues.
Future
is
warranted
further
explore
techniques,
approaches
comparable
mental
those
seen
forms
high-intensity
interval
heavy
Language: Английский
An in vitro model for studying crosstalk between muscle cells and neurons
Device,
Journal Year:
2025,
Volume and Issue:
3(1), P. 100655 - 100655
Published: Jan. 1, 2025
Language: Английский
Magnetic Actuation for Mechanomedicine
Advanced Intelligent Systems,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 20, 2024
In
the
perspective
of
this
article,
emergence
materials
and
systems
for
magneto‐mechanical
actuation
in
field
mechanobiology
is
presented,
their
potential
to
promote
advance
biomedical
research
discussed.
These
materials,
ranging
from
single
particles
compliant
2D
substrates
3D
scaffolds,
enable
mechanical
modulation
cells
a
remote,
dynamic,
reversible
fashion.
features
represent
major
enabling
researchers
reproduce
time‐evolving
physiological
pathological
processes
vitro
transmit
forces
deformations
activate
cellular
responses
or
directed
cell
migration.
As
smart
platforms,
magneto‐responsive
may
accelerate
discovery
mechanically
mediated
mechanisms
as
therapeutic
targets.
addition,
low
magnetic
susceptibility
biological
tissues
facilitate
translation
approaches
vivo
settings,
opening
new
routes
applications.
Language: Английский