Organoid Vascularization: Strategies and Applications DOI
Qianmin Gao, Jian Wang, Hao Zhang

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

Abstract Organoids provide 3D structures that replicate native tissues in biomedical research. The development of vascular networks within organoids enables oxygen and nutrient delivery while facilitating metabolic waste removal, which supports organoid growth maturation. Recent studies demonstrate vascularized models offer insights into tissue interactions promote regeneration. However, the current limitations establishing functional affect growth, viability, clinical translation potential. This review examines organoids, including mechanisms angiogenesis vasculogenesis, construction strategies, applications. approaches are categorized vivo vitro methods, with analysis their specific advantages limitations. also discusses emerging techniques such as bioprinting gene editing for improving vascularization integration organoid‐based therapies. Current developments indicate potential applications modeling human diseases developing therapeutic contributing to advances translational

Language: Английский

The blood–brain barriers: novel nanocarriers for central nervous system diseases DOI Creative Commons
Jiajun Liu, Ting Wang, Jianwei Dong

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 26, 2025

Abstract The central nervous system (CNS) diseases are major contributors to death and disability worldwide. However, the blood–brain barrier (BBB) often prevents drugs intended for CNS from effectively crossing into brain parenchyma deliver their therapeutic effects. is a semi-permeable with high selectivity. BBB primarily manages transport of substances between blood CNS. To enhance drug delivery disease treatment, various brain-based strategies overcoming have been developed. Among them, nanoparticles (NPs) emphasized due multiple excellent properties. This review starts an overview BBB’s anatomical structure physiological roles, then explores mechanisms, both endogenous exogenous, that facilitate NP passage across BBB. text also delves how nanoparticles' shape, charge, size, surface ligands affect ability cross offers different nanoparticle classifications. concludes examination current challenges in utilizing nanomaterials discusses corresponding directions solutions. aims propose innovative diagnostic approaches design more effective Graphical abstract

Language: Английский

Citations

5
Piezoelectric materials for bone implants: opportunities and challenges DOI

Xionggang Chen,

Shiping Zhang, Shun Peng

et al.

Nano Energy, Journal Year: 2025, Volume and Issue: unknown, P. 110841 - 110841

Published: March 1, 2025

Language: Английский

Citations

0
Intelligent Manufacturing for Osteoarthritis Organoids DOI Creative Commons
Xin Lyu, Jian Wang, Jiacan Su

et al.

Cell Proliferation, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

ABSTRACT Osteoarthritis (OA) is the most prevalent degenerative joint disease worldwide, imposing a substantial global burden. However, its pathogenesis remains incompletely understood, and effective treatment strategies are still lacking. Organoid technology, in which stem cells or progenitor self‐organise into miniature tissue structures under three‐dimensional (3D) culture conditions, provides promising vitro platform for simulating pathological microenvironment of OA. This approach can be employed to investigate mechanisms, carry out high‐throughput drug screening facilitate personalised therapies. review summarises structure, OA manifestations, thereby establishing context application organoid technology. It then examines components arthrosis system, specifically addressing cartilage, subchondral bone, synovium, skeletal muscle ligament organoids. Furthermore, it details various constructing organoids, including considerations cell selection, classification fabrication techniques. Notably, this introduces concept intelligent manufacturing organoids by incorporating emerging engineering technologies such as artificial intelligence (AI) process, forming an innovative software hardware cluster. Lastly, discusses challenges currently facing highlights future directions rapidly evolving field. By offering comprehensive overview state‐of‐the‐art methodologies challenges, anticipates that intelligent, automated will expedite fundamental research, discovery translational applications orthopaedic

Language: Английский

Citations

0
Organoid Vascularization: Strategies and Applications DOI
Qianmin Gao, Jian Wang, Hao Zhang

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

Abstract Organoids provide 3D structures that replicate native tissues in biomedical research. The development of vascular networks within organoids enables oxygen and nutrient delivery while facilitating metabolic waste removal, which supports organoid growth maturation. Recent studies demonstrate vascularized models offer insights into tissue interactions promote regeneration. However, the current limitations establishing functional affect growth, viability, clinical translation potential. This review examines organoids, including mechanisms angiogenesis vasculogenesis, construction strategies, applications. approaches are categorized vivo vitro methods, with analysis their specific advantages limitations. also discusses emerging techniques such as bioprinting gene editing for improving vascularization integration organoid‐based therapies. Current developments indicate potential applications modeling human diseases developing therapeutic contributing to advances translational

Language: Английский

Citations

0