Lycium‐Barbarum Polysaccharide‐Loaded Dual‐Crosslinked Rigid Hydrogel Enhances Bone Healing in Diabetic Bone Defects by Scavenging Reactive Oxygen Species DOI Creative Commons

Wenjie Zhong,

Wenao Liao,

L XU

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Abstract Diabetes‐induced oxidative stress can lead to poor bone defect healing, severely affecting the quality of life for patients. Studies show that improving microenvironment and promoting formation effectively accelerate healing defects. However, traditional local drug delivery methods face various challenges during treatment process. Therefore, this study develops a novel hydrogel (HLBP) loaded with natural protein polysaccharides (LBP) extracted from goji berries, aiming enhance diabetic The is composed freeze‐dried polyvinyl alcohol (PVA) photocrosslinked poly (ethylene glycol) diacrylate (PEGDA). This exhibits excellent biocompatibility. Additionally, it demonstrates effective loading capacity LBP. LBP's bioactivity enables ROS scavenging promotes regeneration at sites. In vitro, experimental results HLBP significantly reduces levels enhances osteogenic differentiation ability cell viability human marrow mesenchymal stem cells. vivo studies using BKS‐db mice implantation defects achieves over 80% highlighting its strong potential. method avoids potential toxicity systemic administration site, providing new strategy treating

Language: Английский

Lycium‐Barbarum Polysaccharide‐Loaded Dual‐Crosslinked Rigid Hydrogel Enhances Bone Healing in Diabetic Bone Defects by Scavenging Reactive Oxygen Species DOI Creative Commons

Wenjie Zhong,

Wenao Liao,

L XU

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Abstract Diabetes‐induced oxidative stress can lead to poor bone defect healing, severely affecting the quality of life for patients. Studies show that improving microenvironment and promoting formation effectively accelerate healing defects. However, traditional local drug delivery methods face various challenges during treatment process. Therefore, this study develops a novel hydrogel (HLBP) loaded with natural protein polysaccharides (LBP) extracted from goji berries, aiming enhance diabetic The is composed freeze‐dried polyvinyl alcohol (PVA) photocrosslinked poly (ethylene glycol) diacrylate (PEGDA). This exhibits excellent biocompatibility. Additionally, it demonstrates effective loading capacity LBP. LBP's bioactivity enables ROS scavenging promotes regeneration at sites. In vitro, experimental results HLBP significantly reduces levels enhances osteogenic differentiation ability cell viability human marrow mesenchymal stem cells. vivo studies using BKS‐db mice implantation defects achieves over 80% highlighting its strong potential. method avoids potential toxicity systemic administration site, providing new strategy treating

Language: Английский

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