Materials Science and Engineering R Reports, Journal Year: 2019, Volume and Issue: 137, P. 66 - 105
Published: Feb. 5, 2019
Language: Английский
Bioengineering & Translational Medicine, Journal Year: 2022, Volume and Issue: 8(2)
Published: Nov. 2, 2022
Abstract Poly(lactic‐ co ‐glycolic acid) (PLGA) nanoparticles (NPs) are commonly used for drug delivery because of their favored biocompatibility and suitability sustained controlled release. To prolong NP circulation time, enable target‐specific overcome physiological barriers, NPs camouflaged in cell membranes have been developed evaluated to improve delivery. Here, we discuss recent advances membrane‐coated PLGA NPs, preparation methods, application cancer therapy, management inflammation, treatment cardiovascular disease control infection. We address the current challenges highlight future research directions needed effective use membrane‐camouflaged NPs.
Language: Английский
Citations
85
Advanced Materials, Journal Year: 2022, Volume and Issue: 34(12)
Published: Jan. 19, 2022
Overactivated T cells and overproduced pro-inflammatory cytokines form a self-amplified signaling loop to continuously exacerbate the dysregulated inflammatory response propel progression of autoimmune diseases (AIDs). Herein, immuno-engineered nanodecoys (NDs) based on poly(lactic-co-glycolic acid) nanoparticles coated with programmed death-ligand 1 (PD-L1)-expressing macrophage membrane (PRM) are developed mediate multi-target interruption self-promoted cascade in AIDs. The PRM collected from IFN-γ-treated RAW 264.7 possesses elevated surface levels adhesion molecule receptors cytokine receptors, and, thus, systemically administered NDs afford higher accumulation level inflamed tissues stronger scavenging efficiency toward multiple cytokines. More importantly, IFN-γ treatment induces remarkable PD-L1 expression PRM, thereby allowing bind membrane-bound death-1 (PD-1) CD4+ cell surfaces or neutralize free soluble PD-1, which reconstructs PD-1/PD-L1 inhibitory axis suppress activation restore immune tolerance. As such, provoke potent cooperative anti-inflammatory immune-suppressive efficacies alleviate damages Zymosan A-induced arthritis mice dextran sulfate sodium-induced ulcerative colitis mice. This study provides an enlightened example for immuno-engineering cell-membrane-based NDs, rendering promising implications into AIDs via immune-modulation.
Language: Английский
Citations
77
Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 185, P. 114294 - 114294
Published: April 15, 2022
Language: Английский
Citations
72
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(5), P. 674 - 674
Published: May 16, 2024
The escalating demand for enhanced therapeutic efficacy and reduced adverse effects in the pharmaceutical domain has catalyzed a new frontier of innovation research field pharmacy: novel drug delivery systems. These systems are designed to address limitations conventional administration, such as abbreviated half-life, inadequate targeting, low solubility, bioavailability. As disciplines pharmacy, materials science, biomedicine continue advance converge, development efficient safe systems, including biopharmaceutical formulations, garnered significant attention both domestically internationally. This article presents an overview latest advancements categorized into four primary areas: carrier-based coupling-based targeted intelligent devices, based on their main objectives methodologies. Additionally, it critically analyzes technological bottlenecks, current challenges, future trends application
Language: Английский
Citations
19
Materials Science and Engineering R Reports, Journal Year: 2019, Volume and Issue: 137, P. 66 - 105
Published: Feb. 5, 2019
Language: Английский
Citations
146