Mesoporous silica/organosilica nanoparticles: Synthesis, biological effect and biomedical application DOI
Bowen Yang, Yu Chen, Jianlin Shi

et al.

Materials Science and Engineering R Reports, Journal Year: 2019, Volume and Issue: 137, P. 66 - 105

Published: Feb. 5, 2019

Language: Английский

Biomimetic cell membrane‐coated poly(lactic‐ co ‐glycolic acid) nanoparticles for biomedical applications DOI Creative Commons
Nasrullah Jan, Asadullah Madni, Safiullah Khan

et al.

Bioengineering & Translational Medicine, Journal Year: 2022, Volume and Issue: 8(2)

Published: Nov. 2, 2022

Abstract Poly(lactic‐ co ‐glycolic acid) (PLGA) nanoparticles (NPs) are commonly used for drug delivery because of their favored biocompatibility and suitability sustained controlled release. To prolong NP circulation time, enable target‐specific overcome physiological barriers, NPs camouflaged in cell membranes have been developed evaluated to improve delivery. Here, we discuss recent advances membrane‐coated PLGA NPs, preparation methods, application cancer therapy, management inflammation, treatment cardiovascular disease control infection. We address the current challenges highlight future research directions needed effective use membrane‐camouflaged NPs.

Language: Английский

Citations

85

Immuno‐Engineered Nanodecoys for the Multi‐Target Anti‐Inflammatory Treatment of Autoimmune Diseases DOI
Mengying Hou, Yuansong Wei, Ziyin Zhao

et al.

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(12)

Published: Jan. 19, 2022

Overactivated T cells and overproduced pro-inflammatory cytokines form a self-amplified signaling loop to continuously exacerbate the dysregulated inflammatory response propel progression of autoimmune diseases (AIDs). Herein, immuno-engineered nanodecoys (NDs) based on poly(lactic-co-glycolic acid) nanoparticles coated with programmed death-ligand 1 (PD-L1)-expressing macrophage membrane (PRM) are developed mediate multi-target interruption self-promoted cascade in AIDs. The PRM collected from IFN-γ-treated RAW 264.7 possesses elevated surface levels adhesion molecule receptors cytokine receptors, and, thus, systemically administered NDs afford higher accumulation level inflamed tissues stronger scavenging efficiency toward multiple cytokines. More importantly, IFN-γ treatment induces remarkable PD-L1 expression PRM, thereby allowing bind membrane-bound death-1 (PD-1) CD4+ cell surfaces or neutralize free soluble PD-1, which reconstructs PD-1/PD-L1 inhibitory axis suppress activation restore immune tolerance. As such, provoke potent cooperative anti-inflammatory immune-suppressive efficacies alleviate damages Zymosan A-induced arthritis mice dextran sulfate sodium-induced ulcerative colitis mice. This study provides an enlightened example for immuno-engineering cell-membrane-based NDs, rendering promising implications into AIDs via immune-modulation.

Language: Английский

Citations

77

Bacterial membrane vesicles for vaccine applications DOI Creative Commons

Nishta Krishnan,

Luke J. Kubiatowicz,

Maya Holay

et al.

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 185, P. 114294 - 114294

Published: April 15, 2022

Language: Английский

Citations

72

Novel Drug Delivery Systems: An Important Direction for Drug Innovation Research and Development DOI Creative Commons
Qian Chen, Zhen Yang, Haoyu Liu

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(5), P. 674 - 674

Published: May 16, 2024

The escalating demand for enhanced therapeutic efficacy and reduced adverse effects in the pharmaceutical domain has catalyzed a new frontier of innovation research field pharmacy: novel drug delivery systems. These systems are designed to address limitations conventional administration, such as abbreviated half-life, inadequate targeting, low solubility, bioavailability. As disciplines pharmacy, materials science, biomedicine continue advance converge, development efficient safe systems, including biopharmaceutical formulations, garnered significant attention both domestically internationally. This article presents an overview latest advancements categorized into four primary areas: carrier-based coupling-based targeted intelligent devices, based on their main objectives methodologies. Additionally, it critically analyzes technological bottlenecks, current challenges, future trends application

Language: Английский

Citations

19

Mesoporous silica/organosilica nanoparticles: Synthesis, biological effect and biomedical application DOI
Bowen Yang, Yu Chen, Jianlin Shi

et al.

Materials Science and Engineering R Reports, Journal Year: 2019, Volume and Issue: 137, P. 66 - 105

Published: Feb. 5, 2019

Language: Английский

Citations

146