ACS Applied Materials & Interfaces,
Journal Year:
2021,
Volume and Issue:
13(9), P. 10760 - 10767
Published: Feb. 23, 2021
Exosomes
are
natural
delivery
vehicles
because
of
their
original
feature
such
as
low
immunogenicity,
excellent
biocompatibility,
and
migration
capability.
Engineering
exosomes
with
appropriate
ligands
effective
approaches
to
improve
the
cellular
uptake
efficiency
exosomes.
However,
current
strategies
face
considerable
challenges
due
tedious
labor-intensive
operational
process.
Here,
we
designed
a
novel
peptides-equipped
platform
which
can
be
assembled
under
convenient
mild
reaction
condition.
Cell-penetrating
peptides
(CPPs)
was
conjugated
on
HepG2
cells-derived
surface
not
only
enhance
penetrating
capacity
but
also
assist
in
loading
antisense
oligonucleotides
(ASOs).
The
mechanism
investigated
compared
difference
between
modified
resulting
nanosystem
demonstrated
preferential
tropism
for
cells
that
parented
source
tumor
could
remarkably
increase
G3139
efficient
downregulation
antiapoptotic
Bcl-2.
This
work
developed
rapid
strategy
intracellular
nucleic
acids,
thus
providing
more
possibilities
toward
personalized
cancer
medicine.
Chemical Society Reviews,
Journal Year:
2020,
Volume and Issue:
49(21), P. 7533 - 7567
Published: Jan. 1, 2020
This
review
highlights
the
empirical
design
guidelines
and
photophysical
property
manipulation
of
Aza-BODIPY
dyes
latest
advances
in
their
bioapplications.
Theranostics,
Journal Year:
2020,
Volume and Issue:
11(2), P. 614 - 648
Published: Oct. 28, 2020
CRISPR/Cas9
genome
editing
has
gained
rapidly
increasing
attentions
in
recent
years,
however,
the
translation
of
this
biotechnology
into
therapy
been
hindered
by
efficient
delivery
materials
target
cells.
Direct
system
as
a
ribonucleoprotein
(RNP)
complex
consisting
Cas9
protein
and
single
guide
RNA
(sgRNA)
emerged
powerful
widespread
method
for
due
to
its
advantages
transient
reduced
off-target
effects.
In
review,
we
summarized
current
RNP
systems
including
physical
approaches
synthetic
carriers.
The
mechanisms
beneficial
roles
these
strategies
intracellular
were
reviewed.
Examples
development
stimuli-responsive
targeted
carriers
are
highlighted.
Finally,
challenges
perspectives
rational
design
next
generation
promising
field
will
be
discussed.
Coordination Chemistry Reviews,
Journal Year:
2020,
Volume and Issue:
429, P. 213651 - 213651
Published: Dec. 18, 2020
Metal–organic
frameworks
(MOFs)
combined
with
biomacromolecules,
viruses
and
cells
have
emerged
as
novel
biocomposites
for
application
to
drug
delivery,
biosensing,
biospecimen
preservation,
cell
virus
manipulation.
The
integration
of
biological
entities
into
MOF
matrices
generates
functional
characteristics
that
cannot
be
observed
in
the
separate
components,
such
enhanced
chemical
thermal
stability,
resistance
proteases,
MOF-conferred
selectivity,
controlled
release.
In
this
review,
we
will
discuss
these
properties
applications
obtained
by
encapsulation
(i)
proteins,
(ii)
carbohydrates,
(iii)
nucleic
acids,
(iv)
or
a
matrix.
Finally,
review
post
functionalization
MOF-based
carriers
lipids
potential
route
enhance
dispersion,
stability
fluids,
blood
circulation
time
delivery
systems.
Journal of Materials Chemistry B,
Journal Year:
2020,
Volume and Issue:
8(16), P. 3171 - 3191
Published: Jan. 1, 2020
Stimuli-responsive
hydrogel
strain
sensors
that
synergize
the
advantages
of
both
and
smart
functional
materials
have
attracted
increasing
interest
from
material
design
to
emerging
applications
in
health
monitors
human–machine
interfaces.
JACS Au,
Journal Year:
2021,
Volume and Issue:
1(6), P. 710 - 728
Published: May 3, 2021
This
Perspective
focuses
on
thiol-mediated
uptake,
that
is,
the
entry
of
substrates
into
cells
enabled
by
oligochalcogenides
or
mimics,
often
disulfides,
and
inhibited
thiol-reactive
agents.
A
short
chronology
from
initial
observations
in
1990
until
today
is
followed
a
summary
cell-penetrating
poly(disulfide)s
(CPDs)
cyclic
(COCs)
as
privileged
scaffolds
uptake
inhibitors
potential
antivirals.
In
spirit
Perspective,
main
part
brings
together
topics
possibly
could
help
to
explain
how
really
works.
Extreme
sulfur
chemistry
mostly
related
COCs
their
thiosulfinates/-onates,
diselenolanes,
benzopolysulfanes,
but
also
arsenics
Michael
acceptors,
viewed
context
acidity,
ring
tension,
exchange
cascades,
adaptive
networks,
affinity
columns,
molecular
walkers,
ring-opening
polymerizations,
templated
polymerizations.
Micellar
pores
(or
lipid
ion
channels)
are
considered,
peptides
natural
antibiotics
voltage
sensors,
concise
gallery
membrane
proteins,
possible
targets
provided,
including
CLIC1,
chloride
channel;
TMEM16F,
Ca-activated
scramblase;
EGFR,
epithelial
growth
factor
receptor;
protein-disulfide
isomerase,
known
HIV
transferrin
receptor,
top
hit
proteomics
recently
identified
cellular
SARS-CoV-2.
Exploration,
Journal Year:
2022,
Volume and Issue:
2(2)
Published: March 15, 2022
Abstract
Emerging
clustered
regularly
interspaced
short
palindromic
repeat/associated
protein
(CRISPR/Cas)
genome
editing
technology
shows
great
potential
in
gene
therapy.
However,
proteins
and
nucleic
acids
suffer
from
enzymatic
degradation
the
physiological
environment
low
permeability
into
cells.
Exploiting
carriers
to
protect
CRISPR
system
degradation,
enhance
its
targeting
of
specific
tissues
cells,
reduce
immunogenicity
is
essential
stimulate
clinical
applications.
Here,
authors
review
state‐of‐the‐art
delivery
systems
their
applications,
describe
strategies
improve
safety
efficacy
mediated
editing,
categorized
by
three
types
cargo
formats,
that
is,
Cas:
single‐guide
RNA
ribonucleoprotein,
Cas
mRNA
RNA,
plasmid
expressing
CRISPR/Cas
systems.
The
hope
this
will
help
develop
safe
efficient
nanomaterial‐based
for
tools.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(12), P. 7782 - 7853
Published: May 15, 2023
The
high
selectivity
and
affinity
of
antibodies
toward
their
antigens
have
made
them
a
highly
valuable
tool
in
disease
therapy,
diagnosis,
basic
research.
A
plethora
chemical
genetic
approaches
been
devised
to
make
accessible
more
"undruggable"
targets
equipped
with
new
functions
illustrating
or
regulating
biological
processes
precisely.
In
this
Review,
addition
introducing
how
naked
various
antibody
conjugates
(such
as
antibody-drug
conjugates,
antibody-oligonucleotide
antibody-enzyme
etc.)
work
therapeutic
applications,
special
attention
has
paid
chemistry
tools
helped
optimize
the
outcome
(i.e.,
enhanced
efficacy
reduced
side
effects)
facilitate
multifunctionalization
antibodies,
focus
on
emerging
fields
such
targeted
protein
degradation,
real-time
live-cell
imaging,
catalytic
labeling
decaging
spatiotemporal
control
well
engagement
inside
cells.
With
advances
modern
biotechnology,
well-designed
derivatives
via
size
miniaturization
together
efficient
delivery
systems
emerged,
which
gradually
improved
our
understanding
important
paved
way
pursue
novel
for
potential
treatments
diseases.
Advanced Functional Materials,
Journal Year:
2020,
Volume and Issue:
30(37)
Published: May 4, 2020
Abstract
Biopharmaceuticals
have
emerged
to
play
a
vital
role
in
disease
treatment
and
shown
promise
the
rapidly
expanding
pharmaceutical
market
due
their
high
specificity
potency.
However,
delivery
of
these
biologics
is
hindered
by
various
physiological
barriers,
owing
primarily
poor
cell
membrane
permeability,
low
stability,
increased
size
biologic
agents.
Since
many
biological
drugs
are
intended
function
interacting
with
intracellular
targets,
targets
relevance.
In
this
review,
authors
summarize
discuss
use
nanocarriers
for
biopharmaceuticals
via
endosomal
escape
and,
especially,
routes
direct
cytosolic
means
including
caveolae‐mediated
pathway,
contact
release,
intermembrane
transfer,
fusion,
translocation,
disruption.
Strategies
potential
translation
highlighted.
Finally,
conclude
clinical
promising
carriers
future
perspectives.
