Peptide-directed synthesis of chiral nano-bipyramids for controllable antibacterial application DOI Creative Commons
Panpan Chen, Gaoyang Wang,

Changlong Hao

et al.

Chemical Science, Journal Year: 2022, Volume and Issue: 13(35), P. 10281 - 10290

Published: Jan. 1, 2022

The emergence of antibiotic resistance makes the therapeutic effect traditional antibiotics far from satisfactory. Here, chiral gold nano-bipyramids (GBPs) with sea cucumber-like morphology are reported, and used in fight against bacterial infection. Specifically, dipeptide d-/l-Cys-Phe (CF) caused to form a spike shape an optical anisotropy factor 0.102 at 573 nm. antibacterial effects showed that d-GBPs l-GBPs could efficiently destroy bacteria death ratio 98% 70% vitro. Also, both vivo skin infection sepsis models GBPs effectively promote wound healing prevent mice. Mechanistic studies binding affinity (1.071 ± 0.023 × 108 M-1) was 12.39-fold higher than (8.664 0.251 106 protein A Staphylococcus aureus, which further adsorption onto surface. Moreover, physical destruction cell wall by GBPs, resulted stronger for l-GBPs. Furthermore, excellent PTT d-/l-GBPs exacerbated without any side-effect. Overall, have opened new avenue improved efficacy treatment infections.

Language: Английский

Biomedical SERS – the current state and future trends DOI Creative Commons
Dana Cialla‐May, Alois Bonifacio, Thomas Bocklitz

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(18), P. 8957 - 8979

Published: Jan. 1, 2024

Surface enhanced Raman spectroscopy (SERS) is meeting the requirements in biomedical science being a highly sensitive and specific analytical tool. By employing portable systems combination with customized sample pre-treatment, point-of-care-testing (POCT) becomes feasible. Powerful SERS-active sensing surfaces high stability modification layers if required are available for testing application complex biological matrices such as body fluids, cells or tissues. This review summarizes current state collection pretreatment SERS detection protocols, schemes,

Language: Английский

Citations

34
Tuning the Geometry and Optical Chirality of Pentatwinned Au Nanoparticles with 5-Fold Rotational Symmetry DOI

Xuehao Sun,

Lichao Sun,

Lifei Lin

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(13), P. 9543 - 9556

Published: March 22, 2024

Chirality transfer from chiral molecules to nanomaterials represents an important topic for exploring the origin of chirality in many natural and artificial systems. Moreover, developing a promising class holds great significance various applications, including sensing, photonics, catalysis, biomedicine. Here we demonstrate geometric control tunable optical pentatwinned Au nanoparticles with 5-fold rotational symmetry using seed-mediated growth method. A distinctive pathway are observed decahedra as seeds, comparison single-crystal seeds. By employing different peptides inducers, two distinct (pentagonal nanostars pentagonal prisms) obtained. The intriguing formation evolution twinned structure analyzed crystallographic perspective upon maneuvering interplay molecules, surfactants, reducing agents. interesting effects molecular on tuning also explored. Finally, theoretically experimentally investigate far-field near-field properties through numerical simulations single-particle chiroptical measurements. ability tune controlled manner step toward development increasing architectural complexity applications.

Language: Английский

Citations

16
Ultrasmall Magneto-chiral Cobalt Hydroxide Nanoparticles Enable Dynamic Detection of Reactive Oxygen Species in Vivo DOI
Chen Li, Si Li, Jing Zhao

et al.

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(4), P. 1580 - 1588

Published: Jan. 21, 2022

Biological application of chiral nanoparticles (NPs) has aroused enormous levels attention over recent years. Here, we synthesized magneto-chiral cobalt hydroxide (Co(OH)2) NPs that exhibited strong chiroptical and unique magnetic properties applied these to detect monitor reactive oxygen species (ROS) in living cells vivo. Circular dichroism (CD) resonance imaging (MRI) signals the Co(OH)2 a wide intracellular ROS detection range from 0.673 612.971 pmol/106 with corresponding limits (LOD) at 0.087 0.179 cells, far below currently available probes; LOD for d-aspartic acid coated (d-Co(OH)2 NPs) was 5.7 times lower than l-aspartic (l-Co(OH)2 based on CD signals. In addition, d-Co(OH)2 also dynamic monitoring ability. The high selectivity sensitivity complex biological environments can be attributed Co2+ oxidation reaction surface NPs. Furthermore, were able quantify mice by fluorescence MRI Collectively, results reveal exhibit remarkable ability organisms, could therefore provide new tools exploring nanomaterials as potential biosensor investigate events.

Language: Английский

Citations

58
Tunable Reversal of Circular Dichroism in the Seed-Mediated Growth of Bichiral Plasmonic Nanoparticles DOI

Xuehao Sun,

Jian Yang, Lichao Sun

et al.

ACS Nano, Journal Year: 2022, Volume and Issue: 16(11), P. 19174 - 19186

Published: Oct. 17, 2022

Plasmonic nanoparticles with an intrinsic chiral structure have emerged as a promising platform for applications in biosensing, medicine, catalysis, separation, and photonics. Quantitative understanding of the correlation between nanoparticle optical chirality becomes increasingly important but still represents significantly challenging task. Here we demonstrate that tunable signal reversal circular dichroism seed-mediated growth plasmonic can be achieved through hybridization bichiral centers without inverting geometric chirality. Both experimental theoretical results demonstrated opposite sign two different geometries. Chiral molecules were found to not only contribute transfer from also manipulate structural evolution synergistically drive formation centers. By deliberately adjusting concentration other synthetic parameters, such reducing agent concentration, capping surfactant amount Au precursor, been able fine-tune nanoparticles. We further crystal seeds play crucial roles The insights gained this work shed light on underlying mechanisms dictating intriguing provide knowledge framework guides rational design nanostructures toward chiroptical applications.

Language: Английский

Citations

49
Nanomaterials‐assisted metabolic analysis toward in vitro diagnostics DOI Creative Commons
Jing Yang, Lin Huang, Kun Qian

et al.

Exploration, Journal Year: 2022, Volume and Issue: 2(3)

Published: April 16, 2022

In vitro diagnostics (IVD) has played an indispensable role in healthcare system by providing necessary information to indicate disease condition and guide therapeutic decision. Metabolic analysis can be the primary choice facilitate IVD since it characterizes downstream metabolites offers real-time feedback of human body. Nanomaterials with well-designed composition nanostructure have been developed for construction high-performance detection platforms toward metabolic analysis. Herein, we summarize recent progress nanomaterials-assisted related applications IVD. We first introduce important that nanomaterials play when coupled different platforms, including electrochemical sensors, optical spectrometry, mass spectrometry. further highlight applications, from perspectives both targeted biomarker quantitation untargeted fingerprint extraction. This review provides fundamental insights into function analysis, thus facilitating design next-generation diagnostic devices clinical practice.

Language: Английский

Citations

44
Polarization-directed growth of spiral nanostructures by laser direct writing with vector beams DOI Creative Commons
Xiaolin Lü, Xujie Wang, Shuangshuang Wang

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: March 14, 2023

Abstract Chirality is pivotal in nature which attracts wide research interests from all disciplines and creating chiral matter one of the central themes for chemists material scientists. Despite significant efforts, a simple, cost-effective general method that can produce different kinds metamaterials with high regularity tailorability still demanding but greatly missing. Here, we introduce polarization-directed growth spiral nanostructures via vector beams, tailorable generally applicable to both plasmonic dielectric materials. The self-aligned near field enhances photochemical along polarization, crucial oriented growth. obtained present prominent optical activity g-factor up 0.4, be tuned by adjusting spirality beams. These used sensing enantiomers. metasurfaces also formed arrays sub-mm scale, exhibit over 0.1. However, photoluminescence cadmium sulfide presents very weak luminescence excitation linearly polarized light. A number applications envisioned these such as sensing, separation information storage.

Language: Английский

Citations

36
Chiral Ruthenium Nanozymes with Self‐Cascade Reaction Driven the NO Generation Induced Macrophage M1 Polarization Realizing the Lung Cancer “Cocktail Therapy” DOI
Xu Chen,

Yonglan Yang,

Gang Ye

et al.

Small, Journal Year: 2023, Volume and Issue: 19(28)

Published: April 8, 2023

Abstract Macrophages as the main cause of cancer immunosuppression, how to effectively induce macrophage M1 polarization remain major challenge in lung therapy. Herein, inspired by endogenous reactions, a strategy is proposed coactivate reactive oxygen species (ROS) and nitric oxide (NO) with self‐autocatalytic cascade reaction. To enhance generation NO ROS, Precursor‐Arginine capping agents for inducing synthesis two kinds chiral ruthenium nanozyme (D/L‐Arginine@Ru). Under properties Ru nanozymes through synchronously mimicking activity oxidase synthase (NOS), can rapidly generate 1 O 2 at first stage, then catalyze Arginine produce sufficient NO, thus reverse tumor immunosuppression. Moreover, combination antitumor , realize “cocktail therapy” cell apoptosis well ferroptosis. In addition, chirality influences bioactivity that L‐Arginine@Ru shows better therapeutic effect stronger catalytic natural homology. It hoped high performance an effective reagent provide feasible treatment

Language: Английский

Citations

33
Simultaneous detection of mixed pesticide residues based on portable Raman spectrometer and Au@Ag nanoparticles SERS substrate DOI
Lixin Ma, En Han,

Limei Yin

et al.

Food Control, Journal Year: 2023, Volume and Issue: 153, P. 109951 - 109951

Published: June 26, 2023

Language: Английский

Citations

32
Chiral inorganic nanomaterials for bioapplications DOI Creative Commons
Gaoyang Wang, Hongyu Zhang, Hua Kuang

et al.

Matter, Journal Year: 2023, Volume and Issue: 6(6), P. 1752 - 1781

Published: June 1, 2023

Language: Английский

Citations

31
Raman-Based Techniques in Medical Applications for Diagnostic Tasks: A Review DOI Open Access
Yulia А. Khristoforova, Lyudmila A. Bratchenko, Ivan А. Bratchenko

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(21), P. 15605 - 15605

Published: Oct. 26, 2023

Raman spectroscopy is a widely developing approach for noninvasive analysis that can provide information on chemical composition and molecular structure. High specificity calls different medical diagnostic applications based spectroscopy. This review focuses the Raman-based techniques used in diagnostics provides an overview of such techniques, possible areas their application, current limitations. We have reviewed recent studies proposing conventional surface-enhanced rapid measuring specific biomarkers diseases as cardiovascular disease, cancer, neurogenerative coronavirus disease (COVID-19). As result, we discovered several most promising to identify affected persons by detecting some significant spectral features. analyzed these approaches terms potentially power highlighted remaining challenges limitations preventing translation into clinical settings.

Language: Английский

Citations

29