The Second Near-Infrared (NIR-II) Window Excitable/Emissive Organic/Polymeric Fluorescent Molecules for Bioimaging Application DOI Creative Commons
Guannan Liu, Chenguang Wang, Geyu Lu

et al.

Journal of Innovative Optical Health Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

The fluorescence imaging (FLI) in the second near-infrared window (NIR-II, 1000–1700[Formula: see text]nm) has attracted considerable attention past decade. In contrast to conventional NIR-I excitation (808[Formula: text]nm/980[Formula: text]nm), FLI with NIR-II (1064[Formula: text]nm/other wavelength beyond 1000[Formula: can afford deeper tissue penetration depth high clarity due merits of suppressed photon scattering and diminished autofluorescence. this review, we have summarized excitable/emissive organic/polymeric fluorophores recently developed. characteristics these such as chemical structures photophysical properties also been critically discussed. Furthermore, latest development noninvasive vivo was highlighted. ideal results emphasized importance enabling deep high-resolution imaging. Finally, a perspective on challenges prospects We expected review will be served source inspiration for researchers, stimulating creation novel excitable fostering bioimaging applications.

Language: Английский

Engineering MMP-2 Activated Nanoparticles Carrying B7-H3 Bispecific Antibodies for Ferroptosis-Enhanced Glioblastoma Immunotherapy DOI
Rangrang Fan,

Caili Chen,

Min Mu

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(10), P. 9126 - 9139

Published: April 25, 2023

Administration of bispecific antibodies (biAbs) in tumor therapy is limited by their short half-life and off-target toxicity. Optimized strategies or targets are needed to overcome these barriers. B7-H3 (CD276), a member the B7 superfamily, associated with poor survival glioblastoma (GBM) patients. Moreover, dimer EGCG (dEGCG) synthesized this work enhanced IFN-γ-induced ferroptosis cells vitro vivo. Herein, we prepared recombinant anti-B7-H3×CD3 biAbs constructed MMP-2-sensitive S-biAb/dEGCG@NPs offer combination treatment strategy for efficient systemic GBM elimination. Given targeted delivery microenvironment responsiveness, displayed intracranial accumulation, 4.1-, 9.5-, 12.3-fold higher than that biAb/dEGCG@NPs, biAb/dEGCG complexes, free biAbs, respectively. Furthermore, 50% GBM-bearing mice S-biAb/dEGCG@NP group survived longer 56 days. Overall, can induce elimination boosting effect enhancing immune checkpoint blockade (ICB) immunotherapy may be successful antibody nanocarriers cancer therapy.

Language: Английский

Citations

56
Recent advances in near-infrared-II organic J-aggregates for bio-applications DOI

Junchao Xu,

Xudong Zheng, Tian‐Bing Ren

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 528, P. 216379 - 216379

Published: Jan. 4, 2025

Language: Английский

Citations

4
Photodynamic gel-bombs enhance tumor penetration and downstream synergistic therapies DOI Creative Commons

X.F. Bai,

Fanliang Meng,

Xuejiao Wang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: March 19, 2025

Abstract Nanoparticle-based drug delivery system remains a significant challenge in the current treatment of solid tumors, primarily due to their limited penetration capabilities. Herein, we successfully engineer photodynamic gel-bombs (DCM@OPR) capable penetrating deeply into tumor tissues utilizing photodynamic-triggered explosive energy and receptor-mediated transcytosis, significantly enhancing therapeutic efficacy breast cancer. The were fabricated by loading powerful components chlorin e6 MnO 2 nanoparticles, as well Doxorubicin, crosslinked Ca 2+ -gel. Upon exposure laser irradiation, obtained are generating energy, resulting fragmentation numerous nanofragments. subsequently drives these nanofragments penetrate through gap leakage among cells. In addition, also promotes escape those (including e6, doxorubicin) from lysosomes. subsequent stages, exhibit excellent transcytosis capacity, facilitating deep tissues. As expected, enhanced accumulation can be achieved, anti-proliferation capacity against

Language: Английский

Citations

2
Multimodal optoacoustic imaging: methods and contrast materials DOI Creative Commons
Zhenyue Chen,

Irmak Gezginer,

Quanyu Zhou

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(12), P. 6068 - 6099

Published: Jan. 1, 2024

Combining optoacoustics with other imaging techniques helps bring its powerful label-free functional readings and molecular sensitivity into precise anatomical context while providing an essential cross-validation against established methods.

Language: Английский

Citations

16
Facilely Achieving Near-Infrared-II J-Aggregates through Molecular Bending on a Donor–Acceptor Fluorophore for High-Performance Tumor Phototheranostics DOI
Yingpeng Wan,

Yijian Gao,

Wei‐Chih Wei

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

Constructing J-aggregated organic dyes represents a promising strategy for obtaining biomedical second near-infrared (NIR-II) emissive materials, as they exhibit red-shifted spectroscopic properties upon assembly into nanoparticles (NPs) in aqueous environments. However, currently available NIR-II J-aggregates primarily rely on specific molecular backbones with intricate design strategies and are susceptible to fluorescence quenching during assembly. A facile approach constructing bright using prevalent donor-acceptor (D-A) molecules is still lacking. In this study, we present method that transforms D-A by simply bending the molecule through introducing methyl group, enabling high-performance phototheranostics. The TAA-BT-CN exhibits hypsochromic-shift absorption forming H-aggregated NPs, while designed mTAA-BT-CN bent structure demonstrates bathochromic shift of over 100 nm leading much enhanced emission beyond 1100 nm. With respect its counterpart aggregation-caused (ACQ) phenomenon, NPs 7-fold increase owing their aggregation-induced (AIE) property well efficient generation heat reactive oxygen species under 808 light excitation. Finally, employed whole-body blood vessel imaging technology imaging-guided tumor phototherapies. This study will facilitate flourishing advancement based D-A-type molecules.

Language: Английский

Citations

7
Illuminating the invisible: Advancing bio-imaging and diagnosis with modified near-infrared fluorescents DOI

Liheng Lu,

Nengwen Chen,

Bo Yuan

et al.

Applied Materials Today, Journal Year: 2024, Volume and Issue: 38, P. 102210 - 102210

Published: May 14, 2024

Language: Английский

Citations

4
Facile Alkyne Assembly-Enabled Functional Au Nanosheets for Photoacoustic Imaging-Guided Photothermal/Gene Therapy of Orthotopic Glioblastoma DOI
Xixi Hu,

Peiling Li,

Dongdong Xu

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Treatment of glioblastoma (GBM) remains challenging due to the presence blood-brain barrier (BBB) and tumor heterogeneity. Herein, Au nanosheets (AuNSs) functionalized with RGD peptides small interfering RNA (siRNA), referred as AuNSs-RGD-C≡C-siRNA (ARCR), are prepared achieve multimodal therapy for GBM. The AuNSs a large modifiable surface area, intriguing photothermal conversion efficiency (50.26%), remarkable stability (44 cycles over 7 h) created using well-designed amphiphilic surfactant. Furthermore, alkynyl groups assembled onto within 1 min, enabling strong covalent binding siRNA thereby avoiding interference from biological thiols. Owing lipophilicity surfactant targeting property RGD, ARCR effectively passes through BBB accumulates in GBM regions, allowing near-infrared photoacoustic imaging-guided photothermal/gene therapy. This work proposes facile strategy construct theranostic Au-based materials, highlighting potential multifunctional nanoagents

Language: Английский

Citations

4
Recent Advances in NIR-II Molecular Aggregates and Applications in the Biomedical Field DOI Creative Commons

Kun Wu,

Rong Yang,

Xuefang Song

et al.

Chemosensors, Journal Year: 2025, Volume and Issue: 13(2), P. 67 - 67

Published: Feb. 13, 2025

Near-infrared (NIR) light is a promising tool for biomedical imaging and therapy, offering excellent tissue penetration, low scattering, minimal biological fluorescence interference. An NIR-II optical range of 900–1880 nm with reduced background interference particularly useful disease diagnosis treatment. Probes based on organic molecules are gaining attention their structural flexibility stable performance. Organic molecular aggregates, such as J-aggregates, H-aggregates, aggregation-induced emission (AIE)-aggregates, exhibit unique properties like tunable spectral shifts, improved photostability, higher absorption quantum yields. This mini review briefly discusses the advancements in therapy technologies, focusing classification, formation mechanisms, applications aggregates treatment, theoretical foundation practical guidance future research.

Language: Английский

Citations

0
High‐Efficiency Organic Semiconducting Small Molecule for Deep‐Tissue Phototheranostics: Single 1064 nm Laser Triggered NIR‐IIb Fluorescence Imaging Guided Type‐I Photodynamic/Photothermal Combination Therapy DOI Open Access
Qi Wang, Jiawei Liu,

Linqiang Yang

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract Organic semiconducting small molecules that simultaneously possess NIR‐IIb (1500–1700 nm) fluorescence imaging (FLI), hypoxia‐tolerant photodynamic therapy (PDT) as well photothermal (PTT) abilities activated by a single NIR‐II (1000‐1700 light can achieve high‐performance deep‐tissue phototheranostics, but have not gain much attention. Herein, novel organic molecule (DTT) with an absorption maximum at 844 nm and emission 944 in its monomer state is synthesized through delicate molecular design. Surprisingly, the spectrum of DTT extend into region. Subsequently, phototheranostic nanoparticles (DTT NPs) dramatically red‐shifted absorption/emission peak (1029/1128 are skillfully developed based on J ‐aggregation strategy, which show greatly high molar absorptivity Upon 1064 excitation, resolution FLI be achieved whole‐body vessels, cerebral vasculatures, tumors living mice treated NPs. Moreover, NPs also produce type‐I reactive oxygen species hyperthermia under laser irradiation for oxygen‐less‐dependent PDT PTT combination therapy, eventually achieving efficient antitumor effects. This work provides facile strategy designing high‐efficiency phototheranostics.

Language: Английский

Citations

0
Selective Photothermal Eradication of Glioblastoma Cells Coexisting with Astrocytes by Anti-EGFR-Coated Raman Tags DOI Creative Commons

Yung-Ching Chang,

Chan‐Chuan Liu,

Wan-Ping Chan

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Glioblastoma (GBM) is an aggressive and fatal tumor. The infiltrative spread of GBM cells hinders gross total resection. residual are significantly associated with survival recurrence. Therefore, a theranostic method that can enhance the contrast between normal astrocyte (AS) selectively eradicate highly desired. In this report, both cultured in same microplate well to imitate coexistence environment treated Raman tags functionalized by anti-EGFR. Compared AS cells, show 25% higher emission, their cell death rate increases factor 2. These results demonstrate potential for selective eradication guided robust signals after primary surgery.

Language: Английский

Citations

0