ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(29), P. 18910 - 18921
Published: July 13, 2024
Granzyme
B
is
an
immune-related
biomarker
that
closely
correlates
with
cytotoxic
T
lymphocytes
(CTLs),
and
hence
detecting
the
expression
level
of
granzyme
can
provide
a
dependable
scheme
for
clinical
immune
response
assessment.
In
this
study,
two
positron
emission
tomography
(PET)
probes
[18F]SF-M-14
[18F]SF-H-14
targeting
are
designed
based
on
intramolecular
cyclization
scaffold
SF.
respond
to
glutathione
(GSH)
conduct
self-assemble
into
nanoaggregates
enhance
retention
probe
at
target
site.
Both
prepared
high
radiochemical
purity
(>98%)
stability
in
PBS
mouse
serum.
4T1
cells
cocultured
lymphocytes,
reach
maximum
uptake
6.71
±
0.29
3.47
0.09%
ID/mg
0.5
h,
respectively,
but
they
remain
below
1.95
0.22
1.47
0.21%
without
coculture
lymphocytes.
vivo
PET
imaging
shows
tumor
4T1-tumor-bearing
mice
after
immunotherapy
significantly
higher
(3.5
times)
than
untreated
group.
The
treated
BEC
was
4.08
0.16
3.43
0.12%
ID/g,
while
1.04
0.79
1.41
0.11%
respectively.
These
results
indicate
both
have
great
potential
early
evaluation
efficacy.
Journal of Translational Medicine,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: April 9, 2025
Autoimmune
diseases
(AD)
present
substantial
challenges
for
early
diagnosis
and
precise
treatment
due
to
their
intricate
pathogenesis
varied
clinical
manifestations.
While
existing
diagnostic
methods
strategies
have
advanced,
sensitivity,
specificity,
real-time
applicability
in
settings
continue
exhibit
significant
limitations.
In
recent
years,
fluorescent
probes
emerged
as
highly
sensitive
specific
biological
imaging
tools,
demonstrating
potential
AD
research.This
review
examines
the
response
mechanisms
historical
evolution
of
various
types
probes,
systematically
summarizing
latest
research
advancements
application
autoimmune
diseases.
It
highlights
key
applications
biomarker
detection,
dynamic
monitoring
immune
cell
functions,
assessment
drug
efficacy.
Furthermore,
this
article
analyzes
technical
currently
encountered
probe
development
proposes
directions
future
research.
With
ongoing
materials
science,
nanotechnology,
bioengineering,
are
anticipated
achieve
higher
sensitivity
enhanced
functional
integration,
thereby
facilitating
monitoring,
innovative
Overall,
possess
scientific
significance
value
both
related
diseases,
signaling
a
new
era
personalized
precision
medicine.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(42), P. 56519 - 56544
Published: Oct. 14, 2024
Persistent
luminescence
phosphors
(PLPs)
can
remain
luminescent
after
excitation
ceases
and
have
been
widely
explored
in
bioimaging
therapy
since
2007.
In
bioimaging,
PLPs
efficiently
avoid
tissue
autofluorescence
light
scattering
interference
by
collecting
persistent
signals
the
end
of
excitation.
Outstanding
signal-to-background
ratios,
high
sensitivity,
resolution
achieved
with
PLPs.
therapy,
continuously
produce
therapeutic
molecules
such
as
reactive
oxygen
species
removing
sources,
which
realizes
sustained
activity
a
single
dose
stimulation.
However,
most
are
activated
ultraviolet
or
visible
light,
makes
it
difficult
to
reactivate
vivo,
particularly
deep
tissues.
recent
years,
sources
penetration
activate
PLPs,
including
X-ray,
γ-ray,
ultrasound.
Researchers
found
that
various
inorganic
organic
be
ultrasound,
making
these
valuable
imaging
deep-seated
tumors.
These
X-ray/γ-ray/ultrasound-activated
not
systematically
introduced
previous
reviews.
this
review,
we
summarize
recently
developed
ultrasound
luminescence.
The
biomedical
applications
deep-tissue
also
discussed.
This
review
provide
instructions
for
design
deep-tissue-renewable
further
promote
phototheranostics,
noninvasive
biosensing
devices,
energy
harvesting.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 18, 2025
Abstract
Epoxy‐type
afterglow
luminescence
is
a
cascade
reaction
of
photochemical
defects
caused
as
result
the
formation
and
release
epoxy
intermediates,
exhibiting
continuous
phenomenon
that
remains
intrinsic
after
excitation,
with
extremely
impressive
signal‐to‐background
ratio
(SBR)
level
in
vivo.
Afterglow
based
on
this
epoxy‐type
mechanism
ideally
suited
for
applications
developments
diagnosis
treatment
biological
diseases.
In
tutorial
review,
work
aims
to
deeply
elaborate
mechanisms
materials
present
application
imaging
Lastly,
future
perspectives
potential
challenges
technology
preclinical
diagnostic,
therapeutic,
predictive
analyses,
well
clinical
translations
are
discussed.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(29), P. 18910 - 18921
Published: July 13, 2024
Granzyme
B
is
an
immune-related
biomarker
that
closely
correlates
with
cytotoxic
T
lymphocytes
(CTLs),
and
hence
detecting
the
expression
level
of
granzyme
can
provide
a
dependable
scheme
for
clinical
immune
response
assessment.
In
this
study,
two
positron
emission
tomography
(PET)
probes
[18F]SF-M-14
[18F]SF-H-14
targeting
are
designed
based
on
intramolecular
cyclization
scaffold
SF.
respond
to
glutathione
(GSH)
conduct
self-assemble
into
nanoaggregates
enhance
retention
probe
at
target
site.
Both
prepared
high
radiochemical
purity
(>98%)
stability
in
PBS
mouse
serum.
4T1
cells
cocultured
lymphocytes,
reach
maximum
uptake
6.71
±
0.29
3.47
0.09%
ID/mg
0.5
h,
respectively,
but
they
remain
below
1.95
0.22
1.47
0.21%
without
coculture
lymphocytes.
vivo
PET
imaging
shows
tumor
4T1-tumor-bearing
mice
after
immunotherapy
significantly
higher
(3.5
times)
than
untreated
group.
The
treated
BEC
was
4.08
0.16
3.43
0.12%
ID/g,
while
1.04
0.79
1.41
0.11%
respectively.
These
results
indicate
both
have
great
potential
early
evaluation
efficacy.
