BMEMat,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 29, 2024
Abstract
The
emergence
of
multidrug‐resistant
bacteria
poses
a
significant
challenge
in
the
treatment
osteomyelitis,
rendering
traditional
antibiotic
strategies
inadequate
terms
achieving
complete
cure.
In
recent
years,
triggerable
biomaterial‐based,
antibiotic‐free
osteomyelitis
have
rapidly
evolved,
demonstrating
excellent
bactericidal
effects.
Triggerable
biomaterials‐based
theranostics
encompass
physical
signal
response
and
host
immune
modulation
approaches.
These
can
be
effective
against
drug‐resistant
bacteria,
circumventing
gradual
acquisition
resistance
that
often
accompanies
treatment.
Additionally,
inherent
properties
biomaterials
facilitate
precise
imaging
osteomyelitis.
There
is
no
doubt
biomaterial‐mediated,
therapies
are
emerging
as
trend,
which
critically
important
combating
bacteria‐induced
this
review,
we
summarize
latest
advances
from
both
pathogen‐directed
host‐directed
perspectives.
design
regimens
specific
action
mechanisms
biomaterial‐based
nanoplatforms
also
clarified.
Finally,
outline
challenges
faced
by
various
provide
an
outlook
on
prospects
for
synergistic
interactions.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(37)
Published: Feb. 9, 2024
Abstract
The
diagnosis
and
treatment
of
solid
tumors
have
undergone
significant
advancements
marked
by
a
trend
toward
increased
specificity
integration
imaging
therapeutic
functions.
multifaceted
nature
inorganic
oxide
nanomaterials
(IONs),
which
boast
optical,
magnetic,
ultrasonic,
biochemical
modulatory
properties,
makes
them
ideal
building
blocks
for
developing
multifunctional
nanoplatforms.
A
promising
class
materials
that
emerged
in
this
context
are
peptide‐functionalized
(PFIONs),
demonstrated
excellent
performance
therapy,
making
potential
candidates
advancing
tumor
treatment.
Owing
to
the
functionalities
peptides
targeting,
penetration,
responsiveness,
well‐designed
PFIONs
can
specifically
accumulate
release
or
agents
at
sites,
enabling
precise
effective
This
review
provides
an
overview
recent
advances
use
tumors,
highlighting
superiority
as
well
synergistic
Moreover,
discusses
challenges
prospects
depth,
aiming
promote
intersection
interdisciplinary
facilitate
their
clinical
translation
development
personalized
diagnostic
systems
optimizing
material
systems.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(24)
Published: Feb. 19, 2024
Abstract
Bone
implant
biomaterials
are
among
the
most
used
materials
for
clinical
application.
Despite
significant
advances
in
biocompatibility
and
osteoconductivity,
conventional
lack
ability
to
cope
with
pathological
microenvironment
(inflammation,
infection,
residual
tumors,
etc.)
during
bone
repair.
Semiconductor
have
unique
electrical,
optical,
ultrasound,
thermal
response
properties,
which
facilitate
non‐invasively
controllably
dynamic
repair
of
defects.
In
this
review,
design
synthesis
a
new
generation
semiconductor‐driven
summarized,
mechanism
action
semiconductive
biomaterials'
functional
interfaces
process
tissues
discussed,
strategies
problems
encountered
osseointegration
is
provided.
Finally,
review
outlooks
future
implants
defect
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(26)
Published: May 6, 2024
Abstract
Sonodynamic
therapy
(SDT)
is
demonstrated
to
trigger
the
systemic
immune
response
of
organism
and
facilitate
treatment
metastatic
tumors.
However,
SDT‐mediated
neutrophil
extracellular
traps
(NETs)
formation
can
promote
tumor
cell
spread,
thus
weakening
therapeutic
effectiveness
Herein,
amorphous
CoW‐layered
double
hydroxide
(a‐CoW‐LDH)
nanosheets
are
functionalized
with
a
peptidyl
arginine
deiminase
4
(PAD4)
inhibitor,
i.e.,
YW3‐56,
construct
multifunctional
nanoagent
(a‐LDH@356)
for
synergistic
SDT/immunotherapy.
Specifically,
a‐CoW‐LDH
act
as
sonosensitizer
generate
abundant
reactive
oxygen
species
(ROS)
under
US
irradiation.
After
loading
a‐LDH@356
plus
irradiation
not
only
effectively
induces
ROS
generation
immunogenic
death,
but
also
inhibits
elevation
citrullinated
histone
H3
(H3cit)
release
NETs,
enabling
enhancement
anti‐tumor
metastasis
effect.
Using
4T1
model,
it
that
combining
YW3‐56
stimulates
an
by
upregulating
proportion
immune‐activated
cells
inducing
polarization
M1
macrophages,
escape
downregulating
expression
PD‐1
on
irradiation,
which
arrests
primary
progression
inhibition
rate
69.5%
prevents
least
number
lung
nodules.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 23, 2024
Low-intensity
ultrasound-mediated
sonodynamic
therapy
(SDT),
which,
by
design,
integrates
sonosensitizers
and
molecular
oxygen
to
generate
therapeutic
substances
(e.g.,
toxic
hydroxyl
radicals,
superoxide
anions,
or
singlet
oxygen)
at
disease
sites,
has
shown
enormous
potential
for
the
effective
treatment
of
a
variety
diseases.
Nanoscale
play
crucial
role
in
SDT
process
because
their
structural,
compositional,
physicochemical,
biological
characteristics
are
key
determinants
efficacy.
In
particular,
advances
materials
science
nanotechnology
have
invigorated
series
optimization
strategies
augmenting
efficacy
nanosonosensitizers.
This
comprehensive
review
systematically
summarizes,
discusses,
highlights
state-of-the-art
studies
on
current
achievements
nanosonosensitizer
enhanced
treatment,
with
an
emphasis
general
design
principles
nanosonosensitizers
strategies,
mainly
including
organic
inorganic
Additionally,
recent
advancements
optimized
applications
aimed
treating
various
diseases,
such
as
cancer,
bacterial
infections,
atherosclerosis,
autoimmune
clarified
detail.
Furthermore,
effects
improved
versatile
thoroughly
discussed.
The
concludes
highlighting
challenges
future
opportunities
this
rapidly
evolving
research
field
expedite
its
practical
clinical
translation
application.
BMEMat,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 29, 2024
Abstract
The
emergence
of
multidrug‐resistant
bacteria
poses
a
significant
challenge
in
the
treatment
osteomyelitis,
rendering
traditional
antibiotic
strategies
inadequate
terms
achieving
complete
cure.
In
recent
years,
triggerable
biomaterial‐based,
antibiotic‐free
osteomyelitis
have
rapidly
evolved,
demonstrating
excellent
bactericidal
effects.
Triggerable
biomaterials‐based
theranostics
encompass
physical
signal
response
and
host
immune
modulation
approaches.
These
can
be
effective
against
drug‐resistant
bacteria,
circumventing
gradual
acquisition
resistance
that
often
accompanies
treatment.
Additionally,
inherent
properties
biomaterials
facilitate
precise
imaging
osteomyelitis.
There
is
no
doubt
biomaterial‐mediated,
therapies
are
emerging
as
trend,
which
critically
important
combating
bacteria‐induced
this
review,
we
summarize
latest
advances
from
both
pathogen‐directed
host‐directed
perspectives.
design
regimens
specific
action
mechanisms
biomaterial‐based
nanoplatforms
also
clarified.
Finally,
outline
challenges
faced
by
various
provide
an
outlook
on
prospects
for
synergistic
interactions.
