Osteoporosis
is
a
systemic
metabolic
disease
that
impairs
bone
remodeling
by
favoring
osteoclastic
resorption
over
osteoblastic
formation.
Nanotechnology-based
therapeutic
strategies
focus
on
the
delivery
of
drug
molecules
to
either
decrease
or
increase
formation
rather
than
regulating
entire
process,
and
osteoporosis
interventions
suffer
from
this
limitation.
Here,
we
present
multifunctional
nanoparticle
based
metal-phenolic
networks
(MPNs)
for
treatment
both
osteoclasts
osteoblasts.
In
osteoporotic
microenvironment,
MPN
nanoparticles
degrade
trigger
release
bioactive
metals
(strontium
ions,
SrII)
promote
osteogenesis
functionalized
phenols
(epigallocatechin
gallate,
EGCG)
suppress
osteoclastogenesis.
Injecting
these
into
tail
vein
an
ovariectomized
mouse
model,
trabecular
loss
has
been
significantly
prevented
in
femoral
head
vertebrae,
along
with
increased
volume
decreased
separation.
Overall,
work
represents
versatile
approach
explore
nanomaterials
related
orthopedic
diseases.
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
39, P. 544 - 561
Published: May 30, 2024
Once
bone
metastasis
occurs
in
lung
cancer,
the
efficiency
of
treatment
can
be
greatly
reduced.
Current
mainstream
treatments
are
focused
on
inhibiting
cancer
cell
growth
and
preventing
destruction.
Microwave
ablation
(MWA)
has
been
used
to
treat
tumors.
However,
MWA
may
damage
surrounding
normal
tissues.
Therefore,
it
could
beneficial
develop
a
nanocarrier
combined
with
microwave
metastasis.
Herein,
microwave-responsive
nanoplatform
(MgFe
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(25)
Published: March 13, 2024
Abstract
The
effects
of
dendron
side
chains
in
polymeric
conjugates
on
tumor
penetration
and
antigen
presentation
are
systematically
examined.
Three
polymer‐gemcitabine
(Gem)
(pG0‐Gem,
pG1‐Gem,
pG2‐Gem)
designed
prepared.
pG2‐Gem
conjugate
uniquely
binds
to
the
mitochondria
cells,
thus
regulating
mitochondrial
dynamics.
interaction
between
promotes
great
accumulation
at
site,
resulting
pronounced
antitumor
an
animal
model.
Such
encouraging
therapeutic
can
be
ascribed
immune
modulation
since
MHC‐1
is
significantly
enhanced
due
fusion
metabolism
alteration
after
treatment.
Crucially,
drug‐free
dendronized
polymer,
pG2,
identified
regulate
dynamics,
regulation
independent
conjugated
Gem.
Furthermore,
combination
with
anti‐PD‐1
antibody
results
a
remarkable
clearance
rate
87.5%
prolonged
survival
over
150
days,
demonstrating
potential
polymers
as
innovative
nanoplatform
for
metabolic
synergistic
immunotherapy.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 10, 2025
Abstract
Small
molecules
as
nanomedicine
carriers
offer
advantages
in
drug
loading
and
preparation.
Selecting
effective
small
for
stable
nanomedicines
is
challenging.
This
study
used
artificial
intelligence
(AI)
to
screen
combinations
self‐assembling
nanomedicines,
employing
physiochemical
parameters
predict
formation
via
machine
learning.
Non‐Steroidal
Anti‐Inflammatory
Drugs
(NSAIDs)
are
identified
antineoplastic
drugs,
with
high
loading.
Nanomedicines,
PEG‐coated
indomethacin/paclitaxel
(PiPTX),
laminarin‐modified
(LiDOX),
developed
extended
circulation
active
targeting
functions.
Indomethacin/paclitaxel
iDOX
exhibits
pH‐responsive
release
the
tumor
microenvironment.
These
enhance
anti‐tumor
effects
reduce
side
effects,
offering
a
rapid
approach
clinical
development.
Osteoporosis
is
a
systemic
metabolic
disease
that
impairs
bone
remodeling
by
favoring
osteoclastic
resorption
over
osteoblastic
formation.
Nanotechnology-based
therapeutic
strategies
focus
on
the
delivery
of
drug
molecules
to
either
decrease
or
increase
formation
rather
than
regulating
entire
process,
and
osteoporosis
interventions
suffer
from
this
limitation.
Here,
we
present
multifunctional
nanoparticle
based
metal-phenolic
networks
(MPNs)
for
treatment
both
osteoclasts
osteoblasts.
In
osteoporotic
microenvironment,
MPN
nanoparticles
degrade
trigger
release
bioactive
metals
(strontium
ions,
SrII)
promote
osteogenesis
functionalized
phenols
(epigallocatechin
gallate,
EGCG)
suppress
osteoclastogenesis.
Injecting
these
into
tail
vein
an
ovariectomized
mouse
model,
trabecular
loss
has
been
significantly
prevented
in
femoral
head
vertebrae,
along
with
increased
volume
decreased
separation.
Overall,
work
represents
versatile
approach
explore
nanomaterials
related
orthopedic
diseases.
