A biguanide chitosan-based hydrogel adhesive accelerates the healing of bacterial-infected wounds

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 342, P. 122397 - 122397

Published: June 13, 2024

Language: Английский

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Principles and Design of Bionic Hydrogel Adhesives for Skin Wound Treatment

Polymers, Journal Year: 2024, Volume and Issue: 16(13), P. 1937 - 1937

Published: July 6, 2024

Over millions of years evolution, nature has developed a myriad unique features that have inspired the design adhesives for wound healing. Bionic hydrogel adhesives, capable adapting to dynamic movements tissues, possess superior biocompatibility and effectively promote healing both external internal wounds. This paper provides systematic review principles these focusing on treatment skin wounds, explores feasibility incorporating nature-inspired properties into their design. The adhesion mechanisms bionic are analyzed from chemical physical perspectives. Materials natural synthetic polymers commonly used as detailed regarding degradability. multifunctional elements trauma treatment, such self-healing, drug release, responsive design, optimization mechanical properties, further explored. aim is overcome limitations conventional treatments offer safer, more effective solution application dressings.

Language: Английский

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Polyphenol-enhanced wet adhesive hydrogel with synergistic mechanical activation and ROS scavenging for accelerating diabetic wound healing

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 157103 - 157103

Published: Oct. 1, 2024

Language: Английский

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A chemical toolkit for the fabrication of antibacterial wet adhesives using one pot synthesis

Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 43, P. 102504 - 102504

Published: Jan. 1, 2025

Language: Английский

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Supramolecular interactions-driven aggregation to prepare lipoic acid-bioadhesives for seawater-immersed wounds

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 6, 2025

Seawater-immersed wounds can be threatened by high pH, permeability and infection, which may lead to the development of chronic wounds. The present study develops an aggregation strategy for rapid preparation α-lipoic acid (LA)-based bioadhesives at room temperature with strong underwater adhesion emergency treatment trauma in maritime activities. are fabricated from LA, MXene Ag+ through their supramolecular interactions, rapidly formed mild environments, showing interface without adhesive failure caused depolymerization, while exhibiting mechanical self-reinforcing. To further improve strength, formation MXene/Ag+/LA interactions was integrated into poly(2-hydroxyethyl methacrylate) (pHEMA) electrospinning manufacture electrospun film strength as 2 MPa. sensitive alkaline environments deprotonation LA. released H+ instantly adjust pH weakly seawater-immersed normal deprotonated LA is exert anti-inflammatory functions. Together antibacterial property, applied provide stable barrier protection correct adverse microenvironment, promoting wound healing.

Language: Английский

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Sericin and Gentamicin-Enhanced Polyurethane-Acrylate Adhesives for Superior Adhesion, Biocompatibility and Antibacterial Property

International Journal of Adhesion and Adhesives, Journal Year: 2025, Volume and Issue: unknown, P. 103988 - 103988

Published: Feb. 1, 2025

Language: Английский

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Strong Bioadhesives from Helical Polypeptides

ACS Macro Letters, Journal Year: 2025, Volume and Issue: 14(3), P. 299 - 305

Published: Feb. 21, 2025

Bioadhesives have emerged as versatile and powerful tools for tissue repair integration with biomedical devices, offering a wide range of applications that captured significant clinical scientific interest. Synthetic polypeptide adhesives are particularly promising candidates bioadhesives, but often face limitations in adhesive strength. In this study, inspired by marine proteins, the secondary structure hydrophobic–hydrophilic balance polypeptides were precisely regulated to transform polyelectrolyte strong adhesive. The resulting demonstrated an strength exceeding 1.0 MPa, more than 10× higher previously reported synthetic cohesion adhesion can be optimized adjusting content hydrophobic residue ratios. More helices enhance interactions between backbone side chains well substrates. addition, these exhibit excellent tolerance acids or alkalis, remarkable variable materials tissues, impressive sealing performance.

Language: Английский

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Facile Synthesis of Intrinsic Antimicrobial Silicone Rubber via Covalent Grafting and Its Properties

Journal of Applied Polymer Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 23, 2025

ABSTRACT Room temperature vulcanized (RTV) silicone rubber, often used in humid environments, is susceptible to microbial degradation, leading performance and aesthetic deterioration. To address this, this study developed an intrinsic antimicrobial RTV rubber (SR/QAS) by blending a quaternary ammonium salt (QAS) agent, dimethyloctadecyl[3‐(trimethoxysilyl)propyl]ammonium chloride (DC5700), into its cross‐linking structure through covalent bonding. The effects of DC5700 on the mechanism, mechanical properties, thermal property, surface wettability were systematically investigated. addition significantly reduced tack‐free time due hydrophilic QAS groups accelerating curing process. Cross‐linking density initially increases then decreases with increasing content. This trend reflected where tensile strength elongation at break attain their peak values concentration 3% DC5700. SR/QAS also exhibits better stability than base enhanced density. In summary, presents straightforward approach prepare which minimizes risk agent leakage. findings offer valuable insights for development application similar materials across diverse fields.

Language: Английский

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Pollen-inspired novel silver/silica composite microsphere capable of synergistic bacteria-killing for bacteria-infected wound treatment

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161830 - 161830

Published: March 1, 2025

Language: Английский

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pH‐Driven Multilevel Controllable Injectable Hydrogel for Wound Sealing

Journal of Applied Polymer Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 29, 2025

ABSTRACT While various biomedical sealants exist, many suffer from several drawbacks. For example, hydrogels with superior sealing properties often exhibit limitations such as conflict‐free, individual, and flexible control over injectability gel physical properties, well regarding applications in diverse scenarios. This article presents PL/OHA, a pH‐driven injectable hydrogel sealant designed for wound sealing. PL/OHA employs dynamic bonds, including Schiff base hydrogen to produce biodegradable biocompatible sealant. By individually adjusting the pH value solid content, gelation time, mechanical adhesion strength of can be flexibly controlled meet different requirements wound‐sealing contexts. Experiments prove that injection time controlled, seconds tens minutes, by changing value. It also exhibits adjustable properties. When content is increased 24% 36%, tensile increases 10.12 25.12 kPa, compressive 97.50 516.61 kPa. remarkable antibacterial activity, healing promotion capacity, excellent biocompatibility. These make it promising candidate future clinical

Language: Английский

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