Light Triggered “Bacterial Bomb” to Amplify Tumor Pyroptosis DOI
Yana Liu, Tao Zeng,

Shiyan Bai

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Abstract Pyroptosis is gaining attention for its ability to activate the immune system. However, controlling induction of specific pyroptotic tumor cell death effectively response a challenge. In this study, novel “bacterial bomb” platform developed and designed precisely regulate pyroptosis using light as trigger, thereby optimizing responses. The employs Escherichia coli (Ec) carrier introduce gasdermin D (GSDMD) plasmid (pGSDMD) into Ec adsorb photosensitizer indocyanine green (ICG) on surface, termed Ec‐pGSDMD‐ICG. ICG has photothermal effects (PTE) photodynamic (PDE). Under 808 nm laser irradiation, generates thermal singlet oxygen ( 1 O 2 ), leading rupture release pGSDMD, which expresses sufficient GSDMD in cells. Furthermore, lipopolysaccharides (LPS) caspase pathways (caspase‐1 caspase‐11), cleave produce GSDMD‐N, inducing Light triggered Ec‐pGSDMD‐ICG not only efficiently induces cells with low content, but also enhances moderate all while activating system effective treatment. This approach opens new strategies research directions mediated immunotherapy.

Language: Английский

Recent Progress of Copper-Based Nanomaterials in Tumor-Targeted Photothermal Therapy/Photodynamic Therapy DOI Creative Commons

Xiqian Zhuo,

Zhongshan Liu, Reyida Aishajiang

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(9), P. 2293 - 2293

Published: Sept. 7, 2023

Nanotechnology, an emerging and promising therapeutic tool, may improve the effectiveness of phototherapy (PT) in antitumor therapy because development nanomaterials (NMs) with light-absorbing properties. The tumor-targeted PTs, such as photothermal (PTT) photodynamic (PDT), transform light energy into heat produce reactive oxygen species (ROS) that accumulate at tumor site. increase ROS levels induces oxidative stress (OS) during carcinogenesis disease development. Because localized surface plasmon resonance (LSPR) feature copper (Cu), a vital trace element human body, Cu-based NMs can exhibit good near-infrared (NIR) absorption excellent In microenvironment (TME), Cu2+ combines H2O2 to O2 is reduced Cu1+ by glutathione (GSH), causing Fenton-like reaction reduces hypoxia simultaneously generates eliminate cells conjunction PTT/PDT. Compared other modalities, PTT/PDT precisely target location kill cells. Moreover, multiple treatment modalities be combined treat using NMs. Herein, we reviewed briefly summarized mechanisms actions role Cu, generated from NMs, PTs. Furthermore, described used applications.

Language: Английский

Citations

11
Intracellular metal ion-based chemistry for programmed cell death DOI
Y You, Zhongying Guo, Tyler Wolter

et al.

Chemical Society Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Intracellular metal ions play essential roles in multiple physiological processes, including catalytic action, diverse cellular intracellular signaling, and electron transfer. It is crucial to maintain ion homeostasis which achieved by the subtle balance of storage release intracellularly along with influx efflux at interface cell membrane. Dysregulation has been identified as a key mechanism triggering programmed death (PCD). Despite importance initiating PCD, molecular mechanisms within these processes are infrequently discussed. An in-depth understanding review role PCD may better uncover novel tools for cancer diagnosis therapy. Specifically, calcium (Ca

Language: Английский

Citations

0
Evolution of nMOFs in photodynamic therapy: from porphyrins to chlorins and bacteriochlorins for better efficacy DOI Creative Commons
Yutao Zou, Jiayi Chen, Yingli Qu

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 18, 2025

Photodynamic therapy (PDT) has gained significant attention due to its non-invasive nature, low cost, and ease of operation. Nanoscale metal-organic frameworks (nMOFs) incorporating porphyrins, chlorins, bacteriochlorins have emerged as one the most prominent photoactive materials for tumor PDT. These nMOFs could enhance water solubility, stability loading efficiency photosensitizers (PSs). Their highly ordered porous structure facilitates O2 diffusion enhances generation 1O2 from hydrophobic bacteriochlorins, thereby improving their efficacy phototherapy. This review provides insights into PDT effects derived bacteriochlorins. It overviews design strategies, types reactive oxygen species (ROS), ROS efficiency, unique biological processes involved in inhibiting cell proliferation, focusing on mechanism by which molecular leads enhanced photochemical properties. Finally, highlights new possibilities offered bacteriochlorins-based PDT, emphasizing how optimized can further improve bioapplication porphyrin derivatives represented PSs. With ongoing research technological advancements, we anticipate that this will garner increased scientific researchers toward porphyrin-based nMOFs, elevating potential a approach treatment malignant tumors.

Language: Английский

Citations

0
Targeting regulated cell death: Apoptosis, necroptosis, pyroptosis, ferroptosis, and cuproptosis in anticancer immunity DOI
Ziyu Guo,

Yihuang Liu,

Danyao Chen

et al.

Journal of Translational Internal Medicine, Journal Year: 2025, Volume and Issue: 13(1), P. 10 - 32

Published: Feb. 1, 2025

In the evolving landscape of cancer treatment, strategic manipulation regulated cell death (RCD) pathways has emerged as a crucial component effective anti-tumor immunity. Evidence suggests that tumor cells undergoing RCD can modify immunogenicity microenvironment (TME), potentially enhancing its ability to suppress progression and metastasis. this review, we first explore mechanisms apoptosis, necroptosis, pyroptosis, ferroptosis, cuproptosis, along with crosstalk between these modalities. We then discuss how processes activate antigen-presenting cells, facilitate cross-priming CD8+ T trigger immune responses, highlighting complex effects novel forms on TME biology. Furthermore, summarize potential drugs nanoparticles induce or inhibit emerging their therapeutic roles in treatment. Finally, put forward existing challenges future prospects for targeting anti-cancer Overall, review enhances our understanding molecular biological impacts RCD-based therapies, providing new perspectives strategies

Language: Английский

Citations

0
Light Triggered “Bacterial Bomb” to Amplify Tumor Pyroptosis DOI
Yana Liu, Tao Zeng,

Shiyan Bai

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Abstract Pyroptosis is gaining attention for its ability to activate the immune system. However, controlling induction of specific pyroptotic tumor cell death effectively response a challenge. In this study, novel “bacterial bomb” platform developed and designed precisely regulate pyroptosis using light as trigger, thereby optimizing responses. The employs Escherichia coli (Ec) carrier introduce gasdermin D (GSDMD) plasmid (pGSDMD) into Ec adsorb photosensitizer indocyanine green (ICG) on surface, termed Ec‐pGSDMD‐ICG. ICG has photothermal effects (PTE) photodynamic (PDE). Under 808 nm laser irradiation, generates thermal singlet oxygen ( 1 O 2 ), leading rupture release pGSDMD, which expresses sufficient GSDMD in cells. Furthermore, lipopolysaccharides (LPS) caspase pathways (caspase‐1 caspase‐11), cleave produce GSDMD‐N, inducing Light triggered Ec‐pGSDMD‐ICG not only efficiently induces cells with low content, but also enhances moderate all while activating system effective treatment. This approach opens new strategies research directions mediated immunotherapy.

Language: Английский

Citations

0