All‐in‐One Self‐Powered Microneedle Device for Accelerating Infected Diabetic Wound Repair

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(13)

Published: Feb. 7, 2024

Abstract Diabetic wound healing remains a significant clinical challenge due to the complex microenvironment and attenuated endogenous electric field. Herein, novel all‐in‐one self‐powered microneedle device (termed TZ@mMN‐TENG) is developed by combining multifunctional carried tannin@ZnO microparticles (TZ@mMN) with triboelectric nanogenerator (TENG). In addition delivery of tannin Zn 2+ , TZ@mMN also effectively conducts electrical stimulation (ES) infected diabetic wounds. As device, TENG can convert biomechanical motion into exogenous ES accelerate healing. vitro experiment demonstrated that shows excellent conductive, high antioxidant ability, effective antibacterial properties against both Staphylococcus aureus Escherichia coli (>99% rates). Besides, TZ@mMN‐TENG promote cell proliferation migration. rat full‐thickness skin model eliminate bacteria, epidermal growth (regenerative epidermis: ≈303.3 ± 19.1 µm), enhance collagen deposition, inhibit inflammation (lower TNF‐α IL‐6 expression), angiogenesis (higher CD31 VEGF expression) repair. Overall, provides promising strategy for application in

Language: Английский

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Research progress of natural polysaccharide-based and natural protein-based hydrogels for bacteria-infected wound healing

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 496, P. 153803 - 153803

Published: July 6, 2024

Language: Английский

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Multifaceted Catalytic Glucose Depletion and Reactive Oxygen Species-Scavenging Nanoenzyme Composite Hydrogel for Facilitating Diabetic Bone Regeneration

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Regeneration of diabetic bone defects remains a formidable challenge due to the chronic hyperglycemic state, which triggers accumulation advanced glycation end products (AGEs) and reactive oxygen species (ROS). To address this issue, we have engineered bimetallic metal–organic framework-derived Mn@Co3O4@Pt nanoenzyme loaded with alendronate Mg2+ ions (termed MCPtA) regulate microenvironment recover osteogenesis/osteoclast homeostasis. Notably, Mn atom substitution in Co3O4 nanocrystalline structure could modulate electronic significantly improve SOD/CAT catalytic activity for ROS scavenging. By integration GOx-like Pt nanoparticles, MCPtA achieved effective multiple cascade performance that facilitated clearance glucose ROS. Furthermore, was encapsulated within glucose-responsive hydrogel cross-linked via borate ester bond, termed PAM, evaluate potential composite cranial defect repair rats. The vitro/vivo experiments as well RNA sequencing analysis demonstrated disrupt glucose-ROS-induced inflammation promoted osteogenesis angiogenesis, consequence, improving therapeutic effects regeneration. This study provided crucial insights into nanoenzyme-mediated microenvironmental regulation

Language: Английский

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Enzyme-mimetic antioxidant nanomaterials for ROS scavenging: Design, classification, and biological applications

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 500, P. 215536 - 215536

Published: Nov. 4, 2023

Language: Английский

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Artificial Phages with Biocatalytic Spikes for Synergistically Eradicating Antibiotic‐Resistant Biofilms

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(32)

Published: June 5, 2024

Antibiotic-resistant pathogens have become a global public health crisis, especially biofilm-induced refractory infections. Efficient, safe, and biofilm microenvironment (BME)-adaptive therapeutic strategies are urgently demanded to combat antibiotic-resistant biofilms. Here, inspired by the fascinating biological structures functions of phages, de novo design spiky Ir@Co

Language: Английский

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Mesenchymal Stem Cell Spheroids Induced by Supramolecular Nanofibers for Diabetic Wound Healing

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(23)

Published: Feb. 14, 2024

Abstract Diabetic wounds, which are a serious complication of diabetes, threat to most diabetic patients and there is lack satisfactory therapeutic strategies. Mesenchymal stem cell (MSC) spheroids under intensive investigation have emerged as particularly promising clinical therapy induce wound healing; however, applications MSC lagged because the difficulties related proper preparation, in situ instruction insufficient efficacy. Herein, novel Biotin‐ D FYIGSR supramolecular hydrogel designed for three‐dimensional (3D) culture MSCs, enables monodispersed MSCs form with high efficacy fairly suitable quick spheroid harvest. demonstrated enhanced paracrine function, exhibited increased survival promoted three overlapping stages healing through integrin α 2 β 1 subunits. These not only accelerated transition from inflammatory phase proliferation by inhibiting neutrophils inducing M2 macrophage transition, but also neovascularization at sites motivate skin regeneration. Ultimately, achieved re‐epithelialization collagen deposition desirable closure. induced facile solution safe efficient treatment great potential application.

Language: Английский

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Multifunctional hydrogel-based engineered extracellular vesicles delivery for complicated wound healing

Theranostics, Journal Year: 2024, Volume and Issue: 14(11), P. 4198 - 4217

Published: Jan. 1, 2024

The utilization of extracellular vesicles (EVs) in wound healing has been well-documented.However, the direct administration free EVs via subcutaneous injection at sites may result rapid dissipation bioactive components and diminished therapeutic efficacy.Functionalized hydrogels provide effective protection, as well ensure sustained release bioactivity during process, making them an ideal candidate material for delivering EVs.In this review, we introduce mechanisms by which accelerate healing, then elaborate on construction strategies engineered EVs.Subsequently, discuss synthesis application delivery systems to enhance complicated healing.Furthermore, face wounds, functionalized with specific microenvironment regulation capabilities, such antimicrobial, anti-inflammatory, immune regulation, used loading EVs, potential approaches addressing these challenges.Ultimately, deliberate future trajectories outlooks, offering a fresh viewpoint advancement artificial intelligence (AI)-energized materials 3D bio-printed multifunctional hydrogel-based dressings biomedical applications.

Language: Английский

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Metal–Organic Framework‐Based Nanomaterials for Regulation of the Osteogenic Microenvironment

Small, Journal Year: 2024, Volume and Issue: 20(29)

Published: Feb. 20, 2024

As the global population ages, bone diseases have become increasingly prevalent in clinical settings. These conditions often involve detrimental factors such as infection, inflammation, and oxidative stress that disrupt homeostasis. Addressing these disorders requires exogenous strategies to regulate osteogenic microenvironment (OME). The regulation of OME can be divided into four processes: induction, modulation, protection, support, each serving a specific purpose. To this end, metal-organic frameworks (MOFs) are an emerging focus nanomedicine, which show tremendous potential due their superior delivery capability. MOFs play numerous roles metal ion donors, drug carriers, nanozymes, photosensitizers, been extensively explored recent studies. This review presents comprehensive introduction by MOF-based nanomaterials. By discussing various functional MOF composites, work aims inspire guide creation sophisticated efficient nanomaterials for disease management.

Language: Английский

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Nanoclay Mediated Self‐Promoted Reactive Oxygen Species Releasing Enables Efficient Antimicrobial

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(45)

Published: May 28, 2024

Abstract Reactive oxygen species (ROS) releasing materials are increasingly used in nanomedicines due to their effectiveness against a broad spectrum of microbes. However, most ROS‐releasing rely on external stimuli such as photoirradiation, either through photodynamic or photocatalytic processes, which limits practical applications. Herein, this work presents novel nanoclay mediated self‐promoted ROS material called vacancies‐rich ZnO/kaolinite (O v ‐rich ZnO/Kaol). Both experiments and density functional theory (DFT) calculations reveal that the introduction kaolinite increases content O ZnO, change electronic structure promotes process adsorption activation, resulting generation · 2 − reduction without photoirradiation. Molecular dynamics simulations confirm enhances interaction between bacterial membrane, promoting bacterial‐killing effect . More importantly, ZnO/Kaol is successfully prepared pilot scale manufacture antibacterial gauze, showed at least 99% activity both Escherichia coli ( E. ) Staphylococcus aureus S. absence light. The as‐prepared also exhibited satisfactory biocompatibility biosafety. This method can offer more benign approach address limitations traditional photoirradiation‐dependent photosensitizers for antimicrobial gauze.

Language: Английский

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Biofilm microenvironment-activated multimodal therapy nanoplatform for effective anti-bacterial treatment and wound healing

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 183, P. 221 - 234

Published: June 6, 2024

Language: Английский

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