Xolography for Biomedical Applications: Dual-color Light-sheet Printing of Hydrogels with Local Control over Shape and Stiffness DOI Creative Commons

Lena Stoecker,

Gerardo Cedillo-Servin,

Niklas F. König

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 22, 2024

Abstract Current challenges in tissue engineering include creation of extracellular environments that support and interact with cells using biochemical, mechanical, structural cues. Spatial control over these cues is currently limited due to a lack suitable fabrication techniques. This study introduces Xolography, an emerging dual-color light-sheet volumetric printing technology, achieve mechanical features for hydrogel-based photoresins at micro-to macroscale while within minutes. We propose water-soluble photoswitch photoinitiator system are the first demonstrate Xolography library naturally-derived, synthetic, thermoresponsive hydrogels. Centimeter-scale, three-dimensional constructs positive 20 µm negative ∼ 100 fabricated properties (compressive moduli 0.2 kPa – 6.5 MPa). Notably, switching from binary grayscaled light projection enables spatial stiffness (0.2 16 kPa). As proof concept, leveraged hydrogels introduce reversible anisotropic shape changes beyond isometric shrinkage. finally viable cell aggregates, laying foundation cell-laden dynamic, cell-instructive tunable fast one-step process. Overall, innovations unlock unique possibilities across multiple biomedical applications.

Language: Английский

Combined Photopolymerization and Localized Photochromism by Aza‐Diarylethene and Hemiindigo Synergy DOI Creative Commons

Maximilian Sacherer,

Henry Dube

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Abstract Molecular photoswitches produce light‐controlled changes at the nanometer scale and can therefore be used to alter states behavior of materials in a truly bottom‐up fashion. Here an escalating photonic complexity material property control with light is shown using recently developed aza‐diarylethene combination hemiindigo (HI) photoswitches. First, as photoswitch polystyrene (PS) reversibly inscribe relief‐type 3D structures into PS. Second, further photoinitiator for light‐induced polymerization methyl acrylate (MA), demonstrating first time chemical reactivity its zwitterionic switching state. Third, HIs are implemented polymerized MA, generating photochromic polymers. At fourth level, binary mixture allows synergize aza‐diarylethene‐induced photopolymerization localized photochromism simultaneously entrapped functional HI. With such multilevel response, utility this particular applications advanced demonstrated.

Language: Английский

Citations

1
Trendbericht Makromolekulare Chemie 2024 DOI
Robert Göstl, Sonja Storch

Nachrichten aus der Chemie, Journal Year: 2024, Volume and Issue: 72(10), P. 52 - 59

Published: Sept. 30, 2024

Abstract Responsive Polymere ändern ihre Materialeigenschaften und reagieren über programmierte molekulare Prozesse auf Umwelteinflüsse. Solche Materialdesigns standen dieses Jahr im Fokus vieler Anwendungen: Sie verbessern die Rezyklierbarkeit, führen zu selbstreguliertem Abbau Selbstheilung, transportieren Wirkstoffe setzen sie frei oder ahmen biologische Systeme mit komplexen Signalverarbeitungsabläufen adaptiven Strukturen nach. Für eine nachhaltige Kunststoffwirtschaft bleiben zudem leitfähige biobasierte Monomere wichtig.

Citations

0
Second Generation Zwitterionic Aza‐Diarylethene: Photoreversible CN Bond Formation, Three‐State Photoswitching, Thermal Energy Release, and Facile Photoinitiation of Polymerization DOI Creative Commons
Henry Dube,

Maximilian Sacherer

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 21, 2024

Abstract Diarylethenes are a well‐studied and optimized class of photoswitches with wide range applications, including data storage, smart materials, or photocontrolled catalysis biological processes. Most recently, aza‐diarylethenes have been developed in which carbon‐carbon bond connections replaced by carbon‐nitrogen connections. This structural elaboration opens up an entire new structure property space expanding the versatility applicability diarylethenes. In this work, we present second generation zwitterionic aza‐diarylethenes, finally allows for fully reversible photoswitching precise control over all three switching states. High‐yielding between neutral open form Z isomer is achieved two different wavelengths light. The third E isomeric state can be reached to 87 % upon irradiation wavelength. Its high energy content >10 kcal/mol released thermally deliberate solvent change as trigger mechanism, rendering into interesting candidates molecular solar thermal storage (MOST) applications. also serves locking state, allowing toggle light‐responsiveness reversibly labile stable switching. Further, states leads highly efficient photopolymerization methyl acrylate (MA), directly harnessing unleashed chemical reactivity our aza‐diarylethene materials application.

Language: Английский

Citations

0
Second Generation Zwitterionic Aza‐Diarylethene: Photoreversible CN Bond Formation, Three‐State Photoswitching, Thermal Energy Release, and Facile Photoinitiation of Polymerization DOI Creative Commons
Henry Dube,

Maximilian Sacherer

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 21, 2024

Abstract Diarylethenes are a well‐studied and optimized class of photoswitches with wide range applications, including data storage, smart materials, or photocontrolled catalysis biological processes. Most recently, aza‐diarylethenes have been developed in which carbon‐carbon bond connections replaced by carbon‐nitrogen connections. This structural elaboration opens up an entire new structure property space expanding the versatility applicability diarylethenes. In this work, we present second generation zwitterionic aza‐diarylethenes, finally allows for fully reversible photoswitching precise control over all three switching states. High‐yielding between neutral open form Z isomer is achieved two different wavelengths light. The third E isomeric state can be reached to 87 % upon irradiation wavelength. Its high energy content >10 kcal/mol released thermally deliberate solvent change as trigger mechanism, rendering into interesting candidates molecular solar thermal storage (MOST) applications. also serves locking state, allowing toggle light‐responsiveness reversibly labile stable switching. Further, states leads highly efficient photopolymerization methyl acrylate (MA), directly harnessing unleashed chemical reactivity our aza‐diarylethene materials application.

Language: Английский

Citations

0
Xolography for Biomedical Applications: Dual-color Light-sheet Printing of Hydrogels with Local Control over Shape and Stiffness DOI Creative Commons

Lena Stoecker,

Gerardo Cedillo-Servin,

Niklas F. König

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 22, 2024

Abstract Current challenges in tissue engineering include creation of extracellular environments that support and interact with cells using biochemical, mechanical, structural cues. Spatial control over these cues is currently limited due to a lack suitable fabrication techniques. This study introduces Xolography, an emerging dual-color light-sheet volumetric printing technology, achieve mechanical features for hydrogel-based photoresins at micro-to macroscale while within minutes. We propose water-soluble photoswitch photoinitiator system are the first demonstrate Xolography library naturally-derived, synthetic, thermoresponsive hydrogels. Centimeter-scale, three-dimensional constructs positive 20 µm negative ∼ 100 fabricated properties (compressive moduli 0.2 kPa – 6.5 MPa). Notably, switching from binary grayscaled light projection enables spatial stiffness (0.2 16 kPa). As proof concept, leveraged hydrogels introduce reversible anisotropic shape changes beyond isometric shrinkage. finally viable cell aggregates, laying foundation cell-laden dynamic, cell-instructive tunable fast one-step process. Overall, innovations unlock unique possibilities across multiple biomedical applications.

Language: Английский

Citations

0