Recent advances in targeted drug delivery for the treatment of glioblastoma

Nanoscale, Journal Year: 2024, Volume and Issue: 16(18), P. 8689 - 8707

Published: Jan. 1, 2024

This review has focused on the up-to-date development of targeted drug delivery systems to GBM, with specific emphasis utilization nanorobotic for active targeting.

Language: Английский

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Polymeric Polylactic Acid–Glycolic Acid-Based Nanoparticles Deliver Nintedanib Across the Blood–Brain Barrier to Inhibit Glioblastoma Growth

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 443 - 443

Published: Jan. 7, 2025

The aim of this study was to investigate the inhibitory effect nintedanib (BIBF) on glioblastoma (GBM) cells and its mechanism action optimize a drug delivery strategy overcome limitations posed by blood-brain barrier (BBB). We analyzed inhibition GBM cell lines following BIBF treatment explored autophagy pathway. cytotoxicity assessed using CCK-8 assay, further techniques such as transmission electron microscopy, Western blotting (WB), flow cytometry were employed demonstrate that could block autophagic pathway inhibiting fusion autophagosomes lysosomes, ultimately limiting proliferation cells. Molecular docking surface plasmon resonance (SPR) experiments indicated specifically binds autophagy-associated protein VPS18, interfering with function normal progression autophagy. However, application in therapy is limited due restricted penetration across BBB. Therefore, utilized poly-lactic-co-glycolic acid (PLGA) nanocarriers system significantly enhance efficiency vivo. In vitro cellular vivo animal model validation demonstrated PLGA-BIBF NPs effectively overcame BBB, enhanced antitumor activity BIBF, improved therapeutic efficacy BALB/c-Nude model. This exerted significant effects binding VPS18 Combined PLGA nanocarrier system, permeability anti-tumor enhanced. Targeting BIBF-VPS18 optimizing through nanotechnology may represent new for treatment, providing innovative clinical ideas theoretical basis patients GBM.

Language: Английский

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Magnetically driven bionic nanorobots enhance chemotherapeutic efficacy and the tumor immune response via precise targeting

The Innovation, Journal Year: 2025, Volume and Issue: 6(2), P. 100777 - 100777

Published: Jan. 18, 2025

We developed magnetically driven bionic drug-loaded nanorobots (MDNs) to accurately target tumors and deliver chemotherapy agents using a customized three-dimensional (3D) magnetic manipulation platform (MMP) system precisely control their movement mode. MDNs were based on polyethylene glycol-modified homogeneous ultrasmall iron oxide nanoparticles (7.02 ± 0.18 nm). Doxorubicin (12% 2% [w/w]) was encapsulated in by an imide bond. could imitate the mode of school wild herrings (e.g., re-dispersion/arrangement/vortex/directional movement) adapt changing complex physiological environment through 3D MMP system. overcame blood flow resistance biological barriers optimized driving properties according vivo imaging (magnetic resonance fluorescence) histopathology. The performance fabricated verified cells tumor-bearing mouse models. showed high efficiency drug delivery targeting at tumor site (>10-fold), lower toxicity than free doxorubicin (5 mg/kg body weight), activated immune response site, significantly lengthened survival for mice. synergistic interaction between underscores immense potential this system, indicating revolution field chemotherapy.

Language: Английский

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Magnetic Micro/nanorobots in Cancer Theranostics: From Designed Fabrication to Diverse Applications

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Cancer poses a substantial threat and serious challenge to public human health, driving the promotion of sophisticated technologies for cancer therapy. While conventional chemotherapy has bottlenecks such as low delivery efficiency, strong toxic side effects, tumor enrichment barriers, magnetic micro/nanorobots (MNRs) emerge promising therapeutic candidates that provide alternative strategies MNR is kind human-made machine micro- or nanosized, reasonably designed, performs command tasks through self-actuated externally controlled propulsion mechanisms, which can be potentially applied in theranostics. Here, this review first introduces components constitute typical MNR, including body part, control function sensing part. Subsequently, elucidates representative fabrication methods construct MNRs from top-down approaches bottom-up approaches, covering injection molding, self-rolling, melt electrospinning writing, deposition, biotemplate method, lithography, assembling, 3D printing, chemical synthesis. Furthermore, focuses on multiple applications facing diagnosis treatment, encompassing imaging, quantification, drug release, synergy with therapies, cell manipulation, surgical assistance. Then, systematically elaborates biocompatibility biosafety MNRs. Finally, challenges faced by are discussed alongside future research directions. This intended scientific guidance may improve comprehension cognition theranostics platform MNRs, promoting prospering practical application development

Language: Английский

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Bio‐Integrated Microrobots: Fabrication, Actuation and Biomedical Applications

Published: March 13, 2025

ABSTRACT Bio‐integrated microrobots (BIMs), which are fabricated with biofriendly materials, biological units (e.g. cells or biomolecules), cell‐material hybrids have emerged as a promising technology for minimally invasive biomedicine. The diminutive size and flexible structures enable BIMs to navigate within narrow, deep, challenging‐to‐reach in vivo regions, performing biopsy, diagnostic, drug delivery, therapeutic functions minimal invasiveness. However, the clinical deployment of is highly orchestrated task that requires consideration material properties, structural design, locomotion, observation, outcomes, side effects on tissues, etc. In this review, we review discuss latest advances bio‐integrated microrobot domain, evaluating various methods associated fabrication, actuation, implementation biomedical BIMs. By comparing advantages shortcomings these techniques, highlights challenges future trends intelligent microrobots, huge potential

Language: Английский

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Drug delivery pathways to the central nervous system via the brain glymphatic system circumventing the blood‐brain barrier

Exploration, Journal Year: 2024, Volume and Issue: unknown

Published: July 9, 2024

Abstract The blood‐brain barrier (BBB) poses daunting challenges in treating diseases associated with the central nervous system (CNS). Recently, traditional notion of absence lymphatic brain is evolving. discovery glymphatic has stimulated tremendous interest developing new strategies for treatment CNS diseases. Leveraging drug delivery may pave a avenue to circumvent BBB and achieve efficient delivery. review focuses on brain, discussing potential factors affecting its functions exploring their connections meningeal system. Finally, provides an overview methods through regulate immunity. These innovative significantly improve utilization create avenues

Language: Английский

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Biomimetic Dual‐Driven Heterojunction Nanomotors for Targeted Catalytic Immunotherapy of Glioblastoma

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 9, 2024

Abstract The existence of the blood–brain barrier (BBB) and characteristics immunosuppressive microenvironment in glioblastoma (GBM) present significant challenges for targeted GBM therapy. To address this, a biomimetic hybrid cell membrane‐modified dual‐driven heterojunction nanomotor (HM@MnO 2 ‐AuNR‐SiO ) is proposed treatment. These nanomotors are designed to bypass BBB target glioma regions by mimicking surface macrophage membranes. More importantly, MnO structure enables propulsion through near‐infrared‐II (NIR‐II) light oxygen bubbles, allowing effective treatment at deep tumor sites. Meanwhile, plasmonic AuNR‐MnO heterostructure facilitates separation electron–hole pairs generates reactive species (ROS), inducing immunogenic death under NIR‐II laser irradiation. Furthermore, reacts release Mn 2+ ions, activating cGAS‐STING pathway enhancing antitumor immunity. In vitro vivo experiments demonstrate that these achieve active targeting infiltration, promoting M1 polarization, dendritic maturation, effector T‐cell activation, thereby catalysis immunotherapy ROS production STING activation.

Language: Английский

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Design and Manufacturing of Micro/Nanorobots

International Journal of Extreme Manufacturing, Journal Year: 2024, Volume and Issue: 6(6), P. 062006 - 062006

Published: Aug. 21, 2024

Abstract Micro/nanorobots (MNRs) capable of performing tasks at the micro- and nanoscale hold great promise for applications in cutting-edge fields such as biomedical engineering, environmental microfabrication. To cope with intricate dynamic environments encountered practical applications, development high performance MNRs is crucial. They have evolved from single-material, single-function, simple structure to multi-material, multi-function, complex structure. However, design manufacturing multi-material three-dimensional structures pose significant challenges that cannot be addressed by conventional serial strategies single-process methods. The material-interface-structure-function/ coupled methods additive/formative/subtractive composite offer opportunity manufacture multi-materials under multi-factor coupling, thus paving way MNRs. In this paper, we take three core capabilities MNRs—mobility, controllability, load capability—as focal point, emphasizing oriented towards their function/performance functional structures. limitations current investigation are also discussed, our envisioned future directions shared. We hope review will provide a framework template MNRs, serving roadmap researchers interested area.

Language: Английский

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Nanorobots mediated drug delivery for brain cancer active targeting and controllable therapeutics

Discover Nano, Journal Year: 2024, Volume and Issue: 19(1)

Published: Nov. 14, 2024

Brain cancer pose significant life-threats by destructively invading normal brain tissues, causing dysneuria, disability and death, its therapeutics is limited underdosage toxicity lying in conventional drug delivery that relied on passive delivery. The application of nanorobots-based systems an emerging field holds great potential for active targeting controllable treatment. ability nanorobots to encapsulate, transport, supply therapies directly the lesion site through blood–brain barriers makes it possible deliver drugs hard-to-reach areas. In order improve efficiency problems such as precision sustained release, are effectively realized converting other forms energy into propulsion motion, which considered high-efficiency methods this article, we described recent advances treatment with mainly from three aspects: firstly, development history characteristics reviewed; secondly, research progress comprehensively investigated, like driving mode mechanism described; thirdly, translation nanorobotics diseases discussed challenges opportunities future outlined.

Language: Английский

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Cooperative Magnetic Interfacial Microrobot Couplefor Versatile Non‐Contact Biomedical Applications

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Abstract Magnetic interfacial microrobots are increasingly recognized as a promising approach for potential biomedical applications ranging from electronic functionalization to minimally invasive surgery and targeted drug delivery. Nevertheless, existing research faces challenges, including less cooperative interactions, contact‐based cargo manipulation, slow transport velocity. Here, the magnetic microrobot couple (CMIMC) is proposed address above challenges. The CMIMC can be maneuvered by single magnet readily switched between capture release states. By leveraging interactions meticulous engineering of capillary forces through shape design surface treatment, demonstrates ability perform non‐contact manipulation. Using synergy preferred magnetization directions field distribution, along with optimization resistance‐reducing shape, significantly enhances velocity, reaching 12.2 body length per second. studies demonstrate various like delivery myomectomy, paving way broad implementation in fields.

Language: Английский

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