Hybrid 3D microfluidic bioprinting for the engineering of cancer models and tissue substitutes DOI Creative Commons
Salvatore D’Alessandro, Sajad Mohammadi, Lucia Iafrate

et al.

Virtual and Physical Prototyping, Journal Year: 2024, Volume and Issue: 19(1)

Published: Nov. 4, 2024

3D bioprinting is at the forefront of tissue engineering to fabricate complex constructs resembling functional tissues. However, inability produce heterogeneous tissues and lack spatio-temporal control over release bioactive factors are greatly limiting clinical translation. Herein, combination with high-throughput dispensing using a custom microfluidic system nanoclay-based inks presented. This approach was found enhance printability, retention, controlled factors. Advanced models were developed resemble cancer skeletal tissue, while studying effect anti-cancer (Doxorubicin) pro-osteogenic growth (bone morphogenetic protein-2, BMP-2), respectively. The new nanoclay ink allowed sustained release, making it suitable for long-term applications. These findings suggest that by combining delivery platform can be assembled, offering significant advancements in regenerative medicine.

Language: Английский

4D printing for biomedical applications DOI
Arkodip Mandal, Kaushik Chatterjee

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(12), P. 2985 - 3005

Published: Jan. 1, 2024

Schematic illustration of 4D printing.

Language: Английский

Citations

11
AI-driven 3D bioprinting for regenerative medicine: From bench to bedside DOI
Huajin Zhang, Xianhao Zhou, Yongcong Fang

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 45, P. 201 - 230

Published: Nov. 23, 2024

Language: Английский

Citations

11
Recent advances in 3D bioprinted polysaccharide hydrogels for biomedical applications: A comprehensive review DOI Creative Commons
Fouad Damiri, Ahmed Fatimi, Yang Liu

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 348, P. 122845 - 122845

Published: Oct. 17, 2024

Polysaccharide hydrogels, which can mimic the natural extracellular matrix and possess appealing physicochemical biological characteristics, have emerged as significant bioinks for 3D bioprinting. They are highly promising applications in tissue engineering regenerative medicine because of their ability to enhance cell adhesion, proliferation, differentiation a manner akin cellular environment. This review comprehensively examines fabrication methods, polysaccharide hydrogel-driven bioprinting, underscoring its potential engineering, drug delivery, medicine. To contribute pertinent knowledge future research this field, critically key aspects, including chemistry carbohydrates, manufacturing techniques, formulation bioinks, characterization polysaccharide-based hydrogels. Furthermore, explores primary advancements 3D-printed encompassing delivery systems with controlled release kinetics targeted therapy, along tissue-engineered constructs bone, cartilage, skin, vascular regeneration. The use these bioprinted hydrogels innovative fields, disease modeling screening, is also addressed. Despite notable progress, challenges, modulating properties polysaccharides, enhancing bioink printability mechanical properties, achieving long-term vivo stability, been highlighted.

Language: Английский

Citations

10
Reduced graphene oxide-mediated electron-hole separation using titanium dioxide increases the photocatalytic antibacterial activity of bone scaffolds DOI
Pei Feng, Haifeng Tian, Feng Yang

et al.

Bio-Design and Manufacturing, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Language: Английский

Citations

1
Micelle-Facilitated Gelation Kinetics and Viscoelasticity of Dynamic Hyaluronan Hydrogels for Bioprinting of Mimetic Constructs and Tissue Repair DOI Creative Commons
Hua Zhang, Yang Luo,

Guanrong Li

et al.

Composites Part B Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 112151 - 112151

Published: Jan. 1, 2025

Language: Английский

Citations

1
Two Material Properties from One Wavelength‐Orthogonal Photoresin Enabled by a Monochromatic Laser Integrated Stereolithographic Apparatus (Mono LISA) DOI Creative Commons
Xingyu Wu, Katharina Ehrmann, Chunyuan Gan

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Abstract Multi‐material printing has experienced critical advances in recent years, yet material property differentiation capabilities remain limited both with regard to the accessible properties – typically hard versus soft and achievable magnitude of differentiation. To enhance multi‐material capabilities, precise photochemical control during 3D is essential. Wavelength‐differentiation a particularly intriguing concept challenging implement. Notably, dual‐wavelength fabricate sections within one object emerged, where curing process insensitive visible light, while UV irradiation inevitably activates entire resin, limiting true spatio‐temporal properties. Until now, pathway‐independent wavelength‐orthogonal not been realized, each wavelength exclusively triggers only two possible reactions, independent order which wavelengths are applied. Herein, multi‐wavelength technique introduced employing tunable laser monochromatically deliver light platform loaded fully resin. Guided by action plots, distinct highly selective toward specific photocycloaddtion reaction utilized generate networks photoresin. Ultimately, together technique, this orthogonally addressable photoresin allows fabricating objects degradable non‐degradable properties, single fabrication step.

Language: Английский

Citations

1
3D printing in musculoskeletal interface engineering: Current progress and future directions DOI
Tianpeng Xu,

Jingdong Rao,

Yongyi Mo

et al.

Advanced Drug Delivery Reviews, Journal Year: 2025, Volume and Issue: 219, P. 115552 - 115552

Published: March 1, 2025

Language: Английский

Citations

1
Hybrid 3D Bioprinting of Sustainable Biomaterials for Advanced Multiscale Tissue Engineering DOI Open Access
Xuejiao Ma,

Mingqi Xu,

Xiaolin Cui

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Abstract 3D printing has greatly improved the precision of cell and biomaterial placement, enabling accurate reproduction tissue models with sustainable potential. Various techniques, including inkjet printing, extrusion‐based vat photopolymerization, offer unique advantages but often fail to replicate full complexity native tissues because material scalability limitations. Hybrid bioprinting, combining multiple techniques in a single process, shown great potential creating complex multifunctional capabilities, ranging from patient‐specific implant fabrication full‐scale organ development. It capitalizes on strengths integration sustainable, renewable biomaterials at varying resolutions, nano microscale. This approach addresses both biological environmental responsibility by minimizing waste enhancing sustainability engineering processes. Despite progress, substantial gap remains between current technologies bioengineering requirements. A deep understanding hybrid its underlying mechanisms is crucial. Herein, this review summarizes discusses recent advancements systems for fabricating multiscale hierarchical models, focusing challenges field. aims insights identify key requirements advancing technology toward developing functional, biomimetic constructs.

Language: Английский

Citations

1
Co-continuous structure enhanced magnetic responsive shape memory PLLA/TPU blend fabricated by 4D printing DOI Creative Commons
Pei Feng, Rongyang Zhao, Feng Yang

et al.

Virtual and Physical Prototyping, Journal Year: 2023, Volume and Issue: 19(1)

Published: Dec. 28, 2023

Combining poly (L-lactic acid) (PLLA) with thermoplastic polyurethane elastomer (TPU) can integrate the advantages of excellent biocompatibility and intrinsic shape memory ability PLLA high elasticity properties TPU in application minimally invasive surgery for bone tissue engineering. However, easily forms a sea-island-like structure matrix, decreasing properties. In this study, co-continuous phase matrix was constructed by adding Fe3O4 nanoparticles due to changed interfacial tension flow behavior TPU, which endowed TPU/PLLA/Fe3O4 blend fabricated via selective laser sintering (SLS) As result, morphology from complete increasing content (0 10wt%), recovery ratios 50 °C water increased 66.67 95.92%. The introduction magnetic responsive alternating field because could heat it generating relative friction particle collisions. Besides, tensile modulus hardness specimen 10wt% increased. addition, demonstrated promoting cell adhesion, spreading, proliferation.

Language: Английский

Citations

18
Cation-crosslinked κ-carrageenan sub-microgel medium for high-quality embedded bioprinting DOI Creative Commons
Hua Zhang, Yang Luo, Zeming Hu

et al.

Biofabrication, Journal Year: 2024, Volume and Issue: 16(2), P. 025009 - 025009

Published: Jan. 10, 2024

Three-dimensional (3D) bioprinting embedded within a microgel bath has emerged as promising strategy for creating intricate biomimetic scaffolds. However, it remains great challenge to construct tissue-scale structures with high resolution by using 3D due the large particle size and polydispersity of medium, well its limited cytocompatibility. To address these issues, novel uniform sub-microgels cell-friendly cationic-crosslinked kappa-carrageenan (κ-Car) are developed through an easy-to-operate mechanical grinding strategy. Theseκ-Car maintain submicron around 642 nm display rapid jamming-unjamming transition 5 s, along excellent shear-thinning self-healing properties, which critical fidelity in construction tissue architecture via bioprinting. Utilizing this new sub-microgel various organ structures, including heart, lungs, trachea, branched vasculature, kidney, auricle, nose, liver, successfully fabricated delicate fine shape fidelity. Moreover, bone marrow mesenchymal stem cells encapsulated printed constructs exhibit remarkable viability exceeding 92.1% robust growth. Thisκ-Car medium offers innovative avenue achieving high-quality bioprinting, facilitating fabrication functional biological structural organizations.

Language: Английский

Citations

8