Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 157381 - 157381
Published: Nov. 1, 2024
Language: Английский
RNA Biology, Journal Year: 2024, Volume and Issue: 21(1), P. 1 - 27
Published: March 26, 2024
Adjuvanticity and delivery are crucial facets of mRNA vaccine design. In modern vaccines, adjuvant functions integrated into nanoparticles, allowing the co-delivery antigen adjuvants in a unified, all-in-one formulation. this formulation, many vaccines utilize immunostimulating properties carrier components, including lipids polymers, as adjuvants. However, careful design is necessary, excessive adjuvanticity activation improper innate immune signalling can conversely hinder vaccination efficacy trigger adverse effects. also require systems to achieve expression antigen-presenting cells (APCs) within lymphoid organs. Some directly target APCs organs, while others rely on migration draining lymph nodes after taking up vaccines. This review explores current mechanistic understanding these processes ongoing efforts improve safety based understanding.
Language: Английский
Citations
9
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2025, Volume and Issue: 17(1)
Published: Jan. 1, 2025
ABSTRACT mRNA delivery has emerged as a transformative approach in biotechnology and medicine, offering versatile platform for the development of novel therapeutics. Unlike traditional small molecule drugs or protein‐based biologics, therapeutics have unique ability to direct cells generate therapeutic proteins, allowing precise modulation biological processes. The into target is critical step realizing potential this technology. In review, our focus on latest advancements designing functional polymers achieve efficient delivery. Biodegradable low molecular weight addressing balance binding release are summarized. Benefiting from excellent performance lipid nanoparticles delivery, polymer/lipid hybrid nanostructures also included. Finally, challenges future prospects polymer‐based systems discussed.
Language: Английский
Citations
1
Nano-Micro Letters, Journal Year: 2025, Volume and Issue: 17(1)
Published: Feb. 21, 2025
The emerging messenger RNA (mRNA) nanomedicines have sprung up for disease treatment. Developing targeted mRNA has become a thrilling research hotspot in recent years, as they can be precisely delivered to specific organs or tissues enhance efficiency and avoid side effects. Herein, we give comprehensive review on the latest progress of with targeting functions. its carriers are first described detail. Then, mechanisms passive targeting, endogenous active outlined, focus various biological barriers that may encounter during vivo delivery. Next, emphasis is placed summarizing mRNA-based organ-targeting strategies. Lastly, advantages challenges clinical translation mentioned. This expected inspire researchers this field drive further development technology.
Language: Английский
Citations
1
Small, Journal Year: 2024, Volume and Issue: 20(43)
Published: July 14, 2024
Abstract Messenger RNA (mRNA) is an emerging class of therapeutic agents for treating a wide range diseases. However, due to the instability and low cell transfection rate naked mRNA, expression delivered mRNA in target cells or tissues vivo requires delivery strategies. Biomimetic vectors hold advantages such as high biocompatibility, tissue specific targeting ability efficient mechanisms, potentially overcoming challenges faced by other vectors. In this review, biomimetic vector‐based systems are summarized discuss possible prospects systems, which may contribute progress application mRNA‐based therapy biomedical field.
Language: Английский
Citations
5
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 3, 2025
Organ- and cell-specific delivery of mRNA via modular lipid nanoparticles (LNPs) is promising in treating various diseases, but targeted cargo still very challenging. Most previous work focuses on screening ionizable helper lipids to address the above issues. Here, we report multifacial role PEGylated manipulating LNP-mediated liver. We employed typical excipients LNP products, including DLin-MC3-DMA, DPSC, cholesterol. Five types were selected, their molar ratio was fixed at 1.5% with a constant PEG molecular weight 2000 Da. The architecture steric dramatically affected vitro gene transfection, vivo blood clearance, liver deposition, targeting specific cells, all which closely linked de-PEGylation rate. fast resulted short circulation high accumulation However, ultrafast enabled deposition more LNPs Kupffer cells other than hepatocytes. Surprisingly, simply changing terminal groups from methoxyl carboxyl or amine could increase LNPs, might be associated accelerated rate enhanced LNP–cell interaction. current highlights importance promoting delivery, offering an alternative approach for formulating optimizing LNPs.
Language: Английский
Citations
0
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 3, 2025
Abstract Non‐iridescent photonic glass pigments of block copolymers show great potential for sustainable structural coloration. However, the ability to create accurate RGB color mixtures real‐world applications is limited by prevalent use non‐degradable, fossil oil‐derived components and difficulty in achieving pure red hues. This work presents an alternative strategy more coloration fabricating composite through controlled self‐assembly water, vegetable oil, biodegradable bottlebrush (BBCPs) a complex emulsion system. The obtained balls feature unprecedented multicompartment structures characterized short‐range ordered assembly water nanodroplets stabilized BBCPs, along with oil droplets these nanodroplets, which substantially enhances resistance Ostwald ripening. Furthermore, new model introduced eliminate disordered scattering, successfully creating overcoming long‐standing limitation versatile chromatic engineering.
Language: Английский
Citations
0
Deleted Journal, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 27, 2025
Abstract Tissue regeneration has raised intensive attention due to its great significance in overcoming various diseases resulting from different injuries. Since the COVID‐19 pandemic, mRNA therapeutics have emerged as innovative strategies prevention and treatment of their unique advantages. Compared traditional regenerative strategies, therapy offers rapid translation into proteins with low production cost high modifiability. Herein, we discuss progress key processes therapy, focusing on therapeutic modification delivery carriers. The preclinical clinical studies for cardiac, lung, liver, kidney, locomotor system, skin lesions neurological disorders were summarized comprehensively. Developing reduce immunogenicity off‐target effects, well optimization system may accelerate pace translation.
Language: Английский
Citations
0
Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 535, P. 216673 - 216673
Published: April 3, 2025
Language: Английский
Citations
0
IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 125 - 144
Published: March 7, 2025
Technological developments in clinical and medical oncology have made it possible to treat certain diseases, like cancer, at the root level through biological processes that requires genes be transcribed translated into proteins. The world has learnt about messenger ribonucleic acids(mRNA) technology last two years, time, shown how quickly can respond situations almost limitless potential for future uses treatment of cancer. genetic instructions or recipe guide cells on use their own machinery build proteins are carried by a molecule called RNA (mRNA). This study demonstrated mRNA powerful tool developing vaccines diseases treatments, allowing human put forth lot effort generating trigger an immune response defends against illnesses preserves organs, marking significant milestone science demonstrating adaptability versatility known unknown treatments.
Language: Английский
Citations
0
Polymer science & technology., Journal Year: 2025, Volume and Issue: unknown
Published: April 25, 2025
Language: Английский
Citations
0