BIO Web of Conferences,
Journal Year:
2024,
Volume and Issue:
142, P. 03020 - 03020
Published: Jan. 1, 2024
This
paper
reviews
the
wide
range
of
applications
and
current
research
status
metamaterials
in
biomedical
field,
demonstrating
their
great
potential
enhancing
diagnostic
accuracy,
promoting
tissue
regeneration,
treating
diseases.
performance
traditional
materials,
have
made
remarkable
progress
field
by
virtue
unique
physical
properties
high
designability.
In
case
terahertz
metamaterials,
precise
detection
biomolecules
tissues
has
been
achieved
combining
sensitivity
with
penetrability
biological
tissues.
Mechanical
on
other
hand,
promote
enhancement
flexible
strain
sensors
advancement
engineering
simulating
mechanical
behavior
addition,
multifunctional
such
as
light-driven,
thermally-driven,
magnetic,
chiral,
electrically-driven
opened
up
new
possibilities
biotechnology
industry.
field.
Despite
challenges
biocompatibility
control
material
degradation
rate,
are
still
promising
for
disease
diagnosis,
treatment,
drug
discovery.
Future
should
focus
improving
biocompatibility,
developing
advanced
manufacturing
technologies,
personalized
medicine,
strengthening
interdisciplinary
collaborations
to
further
explore
biomedicine.
Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(2), P. 177 - 177
Published: Jan. 12, 2024
Magnetite
nanoparticles
(Fe3O4
NPs)
have
been
intensively
investigated
because
of
their
potential
biomedical
applications
due
to
high
saturation
magnetization.
In
this
study,
core–shell
Fe3O4@C
NPs
(core
=
Fe3O4
and
shell
amorphous
carbons,
davg
35.1
nm)
were
synthesized
in
an
aqueous
solution.
Carbon
coating
terminated
with
hydrophilic
–OH
–COOH
groups
imparted
excellent
biocompatibility
hydrophilicity
the
NPs,
making
them
suitable
for
applications.
The
exhibited
ideal
relaxometric
properties
T2
magnetic
resonance
imaging
(MRI)
contrast
agents
(i.e.,
transverse
negligible
longitudinal
water
proton
spin
relaxivities),
exclusively
induce
only
relaxation.
Their
MRI
performance
as
was
confirmed
vivo
by
measuring
MR
images
mice
before
after
intravenous
injection.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 9, 2025
Chiral
nanomaterials
are
widely
investigated
over
recent
decades
due
to
their
biocompatibility
and
unique
chiral
effects.
These
key
properties
have
significantly
promoted
the
rapid
development
of
in
bioengineering
medicine.
In
this
review,
basic
principles
constructing
along
with
latest
progress
research
comprehensively
summarized.
Then,
application
for
diagnosis
neurodegenerative
diseases
(NDDs)
is
systematically
described.
addition,
significant
potential
broad
prospects
treatment
NDDs
highlighted
from
several
aspects,
including
disaggregation
neurofibrils,
scavenging
reactive
oxygen
species,
regulation
microbial-gut-brain
axis,
elimination
senescent
cells,
promotion
directed
differentiation
neural
stem
cells.
Finally,
a
perspective
challenges
future
provided.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 2, 2025
Chirality
is
widespread
in
nature
and
governs
the
properties
of
various
materials
including
inorganic
nanomaterials.
However,
previously
reported
chiral
have
been
limited
to
a
handful
compositions
owing
physicochemical
restrictions
that
impart
chirality.
Herein,
nanopaint
applicable
diverse
presented.
Various
metal
oxide
nanoparticles
(NPs)
show
chiroptical
after
coating
with
our
nanopaint,
while
maintaining
their
properties,
such
as
magnetic
properties.
The
combination
magnetism
chirality
brings
biomedical
functionalities
NPs,
anticancer
hyperthermia
treatment.
In
vitro,
d-nanopainted
iron
NPs
showed
more
than
50%
higher
cellular
uptake
compared
l-nanopainted
this
was
due
enantiospecific
interaction
between
receptors
on
cell
surface
NPs.
vivo,
4-fold
superior
efficiency
by
improved
adsorption
tumors.
These
may
provide
potential
synthesis
strategies
for
biomaterials,
which
exhibit
elaborate
combinations
intrinsic
physical
extrinsic
enantioselective
variety
applications.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 9, 2025
Glioma
is
a
major
cause
of
mortality
among
central
nervous
system
tumors,
with
generally
poor
prognosis.
The
lysyl
oxidase
(LOX)
family,
group
copper-dependent
amine
oxidases,
has
been
implicated
in
the
progression
various
cancers,
but
its
specific
role
glioma
and
relationship
immune
infiltration
remains
insufficiently
explored.
This
study
aims
to
investigate
LOX
family's
expression,
prognostic
significance,
dynamics
identify
potential
therapeutic
targets.
A
comprehensive
analysis
was
conducted
using
public
databases
assess
gene
mutation
frequency,
patterns
related
family
glioma.
results
were
validated
through
survival
immunohistochemistry.
Functional
assays,
including
EdU,
Transwell,
flow
cytometry,
used
evaluate
cell
proliferation,
migration,
invasion,
apoptosis.
Co-culture
experiments
cells,
ELISA,
transplantation
model
employed
immune-modulatory
effects
family.
Gene
protein
expression
levels
further
analyzed
qRT-PCR
Western
blotting.
significantly
upregulated
low-grade
gliomas
strongly
associated
clinical
outcomes.
Although
frequencies
low,
contributed
pathways
involving
metastasis,
hypoxia
response,
angiogenesis,
infiltration.
correlated
increased
macrophages
eosinophils
decreased
presence
Treg
CD8+
T
cells.
Knockdown
genes
impaired
functions,
induced
apoptosis,
altered
behavior
by
reducing
M2
macrophage
polarization
enhancing
activity.
overexpressed
prognosis
patterns.
These
findings
highlight
as
promising
marker
target,
particularly
for
effectiveness
immunotherapy
treatment.
Chemical Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Biomimetic
mineralization
of
iron
oxide
on
cellulose
nanocrystals
creates
chiral
nanowhiskers
with
an
anisotropy-dependent
g
-factor,
altering
the
response
helical
photonic
films
to
magnetic
fields.
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 19, 2025
Magnetic
resonance
imaging
(MRI)
often
employs
contrast
agents
(CAs)
to
improve
the
visualization
of
lesions.
Although
iron-based
oxides
have
been
clinically
approved
as
T2
CAs,
various
obstacles
hindered
their
widespread
commercial
use.
Consequently,
there
is
a
pressing
demand
for
innovative
T2-type
CAs.
Herein,
we
synthesized
an
hydrogen-bonded
organic
framework
(Fe-HOF)
from
Fe-TCPP
and
explored
its
potential
T2-weighted
MRI
CA.
The
Fe-HOF
demonstrated
superior
relaxivity
(r2)
32.067
mM–1
s–1
higher
r2/r1
ratio
45.25
compared
Fe-TCPP.
This
enhancement
may
be
attributed
combination
single-atom
form
Fe3+
with
increased
radius.
Our
findings
indicate
that
6
μmol
[Fe]/kg
dose
significantly
improves
lesion
in
scans
subcutaneous
tumor
model
mice
liver
metastasis
breast
tumor.
simplicity
Fe-HOF'
s
structure
ensures
absence
complex
metal
ions
or
ligands
during
synthesis,
iron
component
can
metabolized
into
endogenous
pool,
resulting
remarkable
biocompatibility
biosafety.
These
pave
way
design
novel
probes
tailored
cancer
characterization
at
stages.
Smart Molecules,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 25, 2025
Abstract
Covalent
organic
cages
(COCs)
are
three‐dimensional
molecules
with
permanent
cavities,
known
for
their
ordered
pore
structures,
excellent
processability,
and
modular
design.
They
have
shown
significant
potential
in
applications
such
as
gas
adsorption,
molecular
separation,
catalysis.
Introducing
chiral
elements
into
COCs
results
confined
which
endows
them
unique
functions
expands
application
prospects.
This
review
summarizes
the
research
progress
on
covalent
cages,
focusing
strategies
incorporating
elements,
structures
synthesis
methods
of
representative
COCs,
advancements
functions.
Additionally,
we
provide
perspectives
future
directions.
We
hope
this
will
inspire
further
interest
creativity
among
researchers
field
leading
to
development
materials
